RT Journal Article SR Electronic(1) A1 Okazaki, Katsunori A1 Kida, HiroshiYR 2004 T1 A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication JF Journal of General Virology, VO 85 IS 8 SP 2131 OP 2137 DO https://doi.org/10.1099/vir.0.80051-0 PB Microbiology Society, SN 1465-2099, AB Glycoprotein B (gB) is the most conserved glycoprotein of herpesviruses and plays important roles in virus infectivity. Two intervening heptad repeat (HR) sequences were found in the C-terminal half of all herpesvirus gBs analysed. A synthetic peptide derived from the HR region (aa 477–510) of bovine herpesvirus type 1 (BoHV-1) gB was studied for its ability to inhibit virus replication. The peptide interfered with cell-to-cell spread and consistently inhibited replication of BoHV-1, with a 50 % effective concentration value (EC50) of 5 μM. Inhibition of replication was obtained not only with herpesviruses including pseudorabies virus and herpes simplex virus type 1 but also partly with Newcastle disease virus. Possible mechanisms of membrane fusion inhibition by the peptide are discussed., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.80051-0