@article{mbs:/content/journal/jgv/10.1099/vir.0.80051-0, author = "Okazaki, Katsunori and Kida, Hiroshi", title = "A synthetic peptide from a heptad repeat region of herpesvirus glycoprotein B inhibits virus replication", journal= "Journal of General Virology", year = "2004", volume = "85", number = "8", pages = "2131-2137", doi = "https://doi.org/10.1099/vir.0.80051-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.80051-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Glycoprotein B (gB) is the most conserved glycoprotein of herpesviruses and plays important roles in virus infectivity. Two intervening heptad repeat (HR) sequences were found in the C-terminal half of all herpesvirus gBs analysed. A synthetic peptide derived from the HR region (aa 477–510) of bovine herpesvirus type 1 (BoHV-1) gB was studied for its ability to inhibit virus replication. The peptide interfered with cell-to-cell spread and consistently inhibited replication of BoHV-1, with a 50 % effective concentration value (EC50) of 5 μM. Inhibition of replication was obtained not only with herpesviruses including pseudorabies virus and herpes simplex virus type 1 but also partly with Newcastle disease virus. Possible mechanisms of membrane fusion inhibition by the peptide are discussed.", }