1887

Abstract

The virus population transmitted by a human immunodeficiency virus type 1 (HIV-1) infected individual undergoes restriction and subsequent diversification in the new host. However, in contrast to men, who have limited virus diversity at seroconversion, there is measurable diversity in viral envelope gene sequences in women infected with clade A HIV-1. In this study, virus sequence diversity in three unrelated, clade A infected women preceding and shortly after seroconversion was evaluated. It was demonstrated that there is measurable evolution of envelope gene sequences over this time interval. Furthermore, in each of the three individuals, amino acid substitutions arose at five or six positions in sequences derived at or shortly after seroconversion relative to sequences obtained from the seronegative sample. Presented here is a model of clade A gp120 to determine the location of substitutions that appeared as the virus population became established in three clade A HIV-1 infected women.

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2004-06-01
2019-10-14
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References

  1. Boussard, C., Doyle, V. E., Mahmood, N., Klimkait, T., Pritchard, M. & Gilbert, I. H. ( 2002; ). Design, synthesis and evaluation of peptide libraries as potential anti-HIV compounds, via inhibition of gp120/cell membrane interactions, using the gp120/cd4/fab17 crystal structure. Eur J Med Chem 37, 883–890.[CrossRef]
    [Google Scholar]
  2. Drummond, A. J., Nicholls, G. K., Rodrigo, A. G. & Solomon, W. ( 2002; ). Estimating mutation parameters, population history and genealogy simultaneously from temporally spaced sequence data. Genetics 161, 1307–1320.
    [Google Scholar]
  3. Kwong, P. D., Wyatt, R., Robinson, J., Sweet, R. W., Sodroski, J. & Hendrickson, W. A. ( 1998; ). Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 393, 648–659.[CrossRef]
    [Google Scholar]
  4. Kwong, P. D., Wyatt, R., Majeed, S., Robinson, J., Sweet, R. W., Sodroski, J. & Hendrickson, W. A. ( 2000a; ). Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates. Structure Fold Des 8, 1329–1339.[CrossRef]
    [Google Scholar]
  5. Kwong, P. D., Wyatt, R., Sattentau, Q. J., Sodroski, J. & Hendrickson, W. A. ( 2000b; ). Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus. J Virol 74, 1961–1972.[CrossRef]
    [Google Scholar]
  6. Kwong, P. D., Doyle, M. L., Casper, D. J. & 18 other authors ( 2002; ). HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites. Nature 420, 678–682.[CrossRef]
    [Google Scholar]
  7. Learn, G. H., Muthui, D., Brodie, S. J., Zhu, T., Diem, K., Mullins, J. I. & Corey, L. ( 2002; ). Virus population homogenization following acute human immunodeficiency virus type 1 infection. J Virol 76, 11953–11959.[CrossRef]
    [Google Scholar]
  8. Long, E. M., Martin, H. L., Jr, Kreiss, J. K., Rainwater, S. M., Lavreys, L., Jackson, D. J., Rakwar, J., Mandaliya, K. & Overbaugh, J. ( 2000; ). Gender differences in HIV-1 diversity at time of infection. Nat Med 6, 71–75.[CrossRef]
    [Google Scholar]
  9. Lovell, S. C., Word, J. M., Richardson, J. S. & Richardson, D. C. ( 2000; ). The penultimate rotamer library. Proteins 40, 389–408.[CrossRef]
    [Google Scholar]
  10. Mo, H., Stamatatos, L., Ip, J. E., Barbas, C. F., Parren, P. W., Burton, D. R., Moore, J. P. & Ho, D. D. ( 1997; ). Human immunodeficiency virus type 1 mutants that escape neutralization by human monoclonal antibody IgG1b12. J Virol 71, 6869–6874.
    [Google Scholar]
  11. Painter, S. L., Biek, R., Holley, D. C. & Poss, M. ( 2003; ). Envelope variants from women recently infected with clade A human immunodeficiency virus type 1 confer distinct phenotypes that are discerned by competition and neutralization experiments. J Virol 77, 8448–8461.[CrossRef]
    [Google Scholar]
  12. Pantophlet, R., Ollmann Saphire, E., Poignard, P., Parren, P. W., Wilson, I. A. & Burton, D. R. ( 2003; ). Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120. J Virol 77, 642–658.[CrossRef]
    [Google Scholar]
  13. Poss, M., Martin, H. L., Kreiss, J. K., Granville, L., Chohan, B., Nyange, P., Mandaliya, K. & Overbaugh, J. ( 1995; ). Diversity in virus populations from genital secretions and peripheral blood in women recently infected with human immunodeficiency virus type 1. J Virol 69, 8118–8122.
    [Google Scholar]
  14. Poss, M., Gosink, J., Thomas, E., Kreiss, J. K., Ndinya-Achola, J., Mandaliya, K., Bwayo, J. & Overbaugh, J. ( 1997; ). Phylogenetic evaluation of Kenyan HIV-1 isolates. AIDS Res Hum Retroviruses 13, 493–499.[CrossRef]
    [Google Scholar]
  15. Poss, M., Rodrigo, A. G., Gosink, J. J., Learn, G. H., de Vange Panteleeff, D. D., Martin, H. L., Jr, Bwayo, J., Kreiss, J. K. & Overbaugh, J. ( 1998; ). Evolution of envelope sequences from the genital tract and peripheral blood of women infected with clade A human immunodeficiency virus type 1. J Virol 72, 8240–8251.
    [Google Scholar]
  16. Rizzuto, C. D., Wyatt, R., Hernandez-Ramos, N., Sun, Y., Kwong, P. D., Hendrickson, W. A. & Sodroski, J. ( 1998; ). A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 280, 1949–1953.[CrossRef]
    [Google Scholar]
  17. Saphire, E. O., Parren, P. W., Pantophlet, R. & 7 other authors ( 2001; ). Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science 293, 1155–1159.[CrossRef]
    [Google Scholar]
  18. Scarlatti, G., Tresoldi, E., Bjorndal, A. & 9 other authors ( 1997; ). In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Nat Med 3, 1259–1265.[CrossRef]
    [Google Scholar]
  19. Speck, R. F., Wehrly, K., Platt, E. J., Atchison, R. E., Charo, I. F., Kabat, D., Chesebro, B. & Goldsmith, M. A. ( 1997; ). Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop. J Virol 71, 7136–7139.
    [Google Scholar]
  20. Vranken, W. F., Fant, F., Budesinsky, M. & Borremans, F. A. ( 2001; ). Conformational model for the consensus V3 loop of the envelope protein gp120 of HIV-1 in a 20 % trifluoroethanol/water solution. Eur J Biochem 268, 2620–2628.[CrossRef]
    [Google Scholar]
  21. Wolfs, T. F., Zwart, G., Bakker, M. & Goudsmit, J. ( 1992; ). HIV-1 genomic RNA diversification following sexual and parenteral virus transmission. Virology 189, 103–110.[CrossRef]
    [Google Scholar]
  22. Wyatt, R., Kwong, P. D., Desjardins, E., Sweet, R. W., Robinson, J., Hendrickson, W. A. & Sodroski, J. G. ( 1998; ). The antigenic structure of the HIV gp120 envelope glycoprotein. Nature 393, 705–711.[CrossRef]
    [Google Scholar]
  23. Zhang, L. Q., MacKenzie, P., Cleland, A., Holmes, E. C., Brown, A. J. & Simmonds, P. ( 1993; ). Selection for specific sequences in the external envelope protein of human immunodeficiency virus type 1 upon primary infection. J Virol 67, 3345–3356.
    [Google Scholar]
  24. Zhu, T., Mo, H., Wang, N., Nam, D. S., Cao, Y., Koup, R. A. & Ho, D. D. ( 1993; ). Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 261, 1179–1181.[CrossRef]
    [Google Scholar]
  25. Zwick, M. B., Kelleher, R., Jensen, R., Labrijn, A. F., Wang, M., Quinnan, G. V., Jr, Parren, P. W. & Burton, D. R. ( 2003; ). A novel human antibody against human immunodeficiency virus type 1 gp120 is V1, V2, and V3 loop dependent and helps delimit the epitope of the broadly neutralizing antibody immunoglobulin G1 b12. J Virol 77, 6965–6978.[CrossRef]
    [Google Scholar]
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