Gut-homing ( ) Th1 memory responses after inactivated poliovirus immunization in poliovirus orally pre-immunized donors Free

Abstract

Mucosal infections are prevented by a specialized local immune system. Immune cells of this compartment can also be found in the blood and are characterized by the expression of mucosa-specific homing molecules. Here, the cellular immune responses after inactivated poliovirus immunization (IPV) in poliovirus orally pre-immunized donors were investigated. Subcutaneous IPV induced a transient increase in the proliferative response against poliovirus antigen and in the number of poliovirus-specific CD4 T cells in the blood of the vaccinees. These cells were characterized to be of the effector memory type (CD45RA/CD45RO/CCR7/CD27) and expressed the homing molecule , indicating their origin from the gut. Together these data show the recurrence of gut-derived poliovirus-specific cells upon IPV and evaluate the whole-blood assay as a powerful tool for monitoring the success of a vaccination.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.79919-0
2004-06-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/85/6/vir851571.html?itemId=/content/journal/jgv/10.1099/vir.0.79919-0&mimeType=html&fmt=ahah

References

  1. Baldridge J. R., McGraw T. S., Paoletti A., Buchmeier M. J. 1997; Antibody prevents the establishment of persistent arenavirus infection in synergy with endogenous T cells. J Virol 71:755–758
    [Google Scholar]
  2. Berlin C., Berg E. L., Briskin M. J., Andrew D. P., Kilshaw P. J., Holzmann B., Weissman I. L., Hamann A., Butcher E. C. 1993; Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell 74:185 [CrossRef]
    [Google Scholar]
  3. Bodian D., Horstmann D. M. 1965; Polioviruses. In Viral and Rickettsial Infections of Man . , 4th edn. pp  430–473 Edited by Horsfall F., Tamm I. Philadelphia: Lippincott;
  4. Butcher E. C., Picker L. J. 1996; Lymphocyte homing and homeostasis. Science 272:60–66 [CrossRef]
    [Google Scholar]
  5. Dittmer U., Brooks D. M., Hasenkrug K. J. 1999; Requirement for multiple lymphocyte subsets in protection by a live attenuated vaccine against retroviral infection. Nat Med 5:189–193 [CrossRef]
    [Google Scholar]
  6. Evans D. T., Chen L. M., Gillis J. 9 other authors 2003; Mucosal priming of simian immunodeficiency virus-specific cytotoxic T-lymphocyte responses in rhesus macaques by the Salmonella type III secretion antigen delivery system. J Virol 77:2400–2409 [CrossRef]
    [Google Scholar]
  7. Faden H., Modlin J. F., Thoms M. L., McBean A. M., Ferdon M. B., Ogra P. L. 1990; Comparative evaluation of immunization with live attenuated and enhanced-potency inactivated trivalent poliovirus vaccines in childhood: systemic and local immune responses. J Infect Dis 162:1291–1297 [CrossRef]
    [Google Scholar]
  8. Hamann D., Baars P. A., Rep M. H., Hooibrink B., Kerkhof-Garde S. R., Klein M. R., van Lier R. A. 1997; Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 186:1407–1418 [CrossRef]
    [Google Scholar]
  9. Heintel T., Sester M., Rodriguez M. M. 7 other authors 2002; The fraction of perforin-expressing HIV-specific CD8 T cells is a marker for disease progression in HIV infection. AIDS 16:1497–1501 [CrossRef]
    [Google Scholar]
  10. Herremans T. M., Reimerink J. H., Buisman A. M., Kimman T. G., Koopmans M. P. 1999; Induction of mucosal immunity by inactivated poliovirus vaccine is dependent on previous mucosal contact with live virus. J Immunol 162:5011–5018
    [Google Scholar]
  11. Hintzen R. Q., de Jong R., Lens S. M., Brouwer M., Baars P., van Lier R. A. 1993; Regulation of CD27 expression on subsets of mature T-lymphocytes. J Immunol 151:2426–2435
    [Google Scholar]
  12. Johansson-Lindbom B., Svensson M., Wurbel M., Malissen B., Marquez G., Agace W. 2003; Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med 198:963–969 [CrossRef]
    [Google Scholar]
  13. Kantele A., Zivny J., Hakkinen M., Elson C. O., Mestecky J. 1999; Differential homing commitments of antigen-specific T cells after oral or parenteral immunization in humans. J Immunol 162:5173–5177
    [Google Scholar]
  14. Mackay C. R. 1999; Dual personality of memory T cells. Nature 401:659–660 [CrossRef]
    [Google Scholar]
  15. Mahon B. P., Katrak K., Nomoto A., Macadam A. J., Minor P. D., Mills K. H. 1995; Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor. J Exp Med 181:1285–1292 [CrossRef]
    [Google Scholar]
  16. Minor P. D. 1990; Antigenic structure of picornaviruses. Curr Top Microbiol Immunol 161:121–154
    [Google Scholar]
  17. Minor P. D., Ferguson M., Katrak K., Wood D., John A., Howlett J., Dunn G., Burke K., Almond J. W. 1990; Antigenic structure of chimeras of type 1 and type 3 poliovirus involving antigenic site 1. J Gen Virol 71:2543–2551 [CrossRef]
    [Google Scholar]
  18. Mora J. R., Bono M. R., Manjunath N., Weninger W., Cavanagh L. L., Rosemblatt M., Von Andrian U. H. 2003; Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 424:88–93 [CrossRef]
    [Google Scholar]
  19. Ogra P. L. 1968; Immunolglobin response in serum and secretions after immunization with live and inactivated poliovaccine and natural infection. N Engl J Med 279:893–900 [CrossRef]
    [Google Scholar]
  20. Sallusto F., Lenig D., Forster R., Lipp M., Lanzavecchia A. 1999; Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708–712 [CrossRef]
    [Google Scholar]
  21. Sester M., Sester U., Köhler H., Schneider T., Deml L., Wagner R., Müller-Lantzsch N., Pees H. W., Meyerhans A. 2000; Rapid whole blood analysis of virus-specific CD4 and CD8 T cell responses in persistent HIV infection. AIDS 14:2653–2660 [CrossRef]
    [Google Scholar]
  22. Sester M., Sester U., Gartner B., Heine G., Girndt M., Mueller-Lantzsch N., Meyerhans A., Kohler H. 2001; Levels of virus-specific CD4 T cells correlate with cytomegalovirus control and predict virus-induced disease after renal transplantation. Transplantation 71:1287–1294 [CrossRef]
    [Google Scholar]
  23. Sicinski P., Rowinski J., Warchol J. B., Jarzabek Z., Gut W., Szczygiel B., Bielecki K., Koch G. 1990; Poliovirus type 1 enters the human host through intestinal M cells. Gastroenterology 98:56–58
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.79919-0
Loading
/content/journal/jgv/10.1099/vir.0.79919-0
Loading

Data & Media loading...

Most cited Most Cited RSS feed