@article{mbs:/content/journal/jgv/10.1099/vir.0.79919-0, author = "Krieg, Carsten and Maier, Reinhard and Meyerhans, Andreas", title = "Gut-homing (α4β7+) Th1 memory responses after inactivated poliovirus immunization in poliovirus orally pre-immunized donors", journal= "Journal of General Virology", year = "2004", volume = "85", number = "6", pages = "1571-1579", doi = "https://doi.org/10.1099/vir.0.79919-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.79919-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Mucosal infections are prevented by a specialized local immune system. Immune cells of this compartment can also be found in the blood and are characterized by the expression of mucosa-specific homing molecules. Here, the cellular immune responses after inactivated poliovirus immunization (IPV) in poliovirus orally pre-immunized donors were investigated. Subcutaneous IPV induced a transient increase in the proliferative response against poliovirus antigen and in the number of poliovirus-specific CD4+ T cells in the blood of the vaccinees. These cells were characterized to be of the effector memory type (CD45RA−/CD45RO+/CCR7−/CD27+) and expressed the homing molecule α 4 β 7, indicating their origin from the gut. Together these data show the recurrence of gut-derived poliovirus-specific cells upon IPV and evaluate the whole-blood assay as a powerful tool for monitoring the success of a vaccination.", }