1887

Abstract

Five novel herpesviruses were identified in suid species from Africa (common warthog, ) and South-East Asia (bearded pig, ; babirusa, ) by detection and analysis of their DNA polymerase genes. Three of the novel species, cytomegalovirus 1, lymphotropic herpesvirus 1 (PafrLHV-1) and lymphotropic herpesvirus 1 (SbarLHV-1), were closely related to known beta- (porcine cytomegalovirus) and gammaherpesviruses [porcine lymphotropic herpesvirus (PLHV) 1 and 3] of domestic pigs. In contrast, two novel species, rhadinovirus 1 (SbarRHV-1) and rhadinovirus 1 (BbabRHV-1), were more closely related to a ruminant gammaherpesvirus, bovine herpesvirus 4 (BoHV-4), than to the porcine gammaherpesviruses PLHV-1, -2, -3, PafrLHV-1 and SbarLHV-1. SbarRHV-1, BbabRHV-1 and BoHV-4 were therefore tentatively assigned to a novel genogroup of artiodactyl gammaherpesviruses. This latter genogroup may also contain an as yet undiscovered gammaherpesvirus of domestic pigs, thereby adding a concern to their use in xenotransplantation.

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2004-04-01
2019-11-18
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References

  1. Albini, S., Zimmermann, W., Neff, F., Ehlers, B., Häni, H., Li, H., Hüssy, D., Engels, M. & Ackermann, M. ( 2003; ). Formal identification of ovine gammaherpesvirus 2 as the agent of porcine malignant catarrhal fever by discrimination from genuine porcine gammaherpesviruses. J Clin Microbiol 41, 900–904.[CrossRef]
    [Google Scholar]
  2. Auchincloss, H., Jr & Sachs, D. H. ( 1998; ). Xenogeneic transplantation. Annu Rev Immunol 16, 433–470.[CrossRef]
    [Google Scholar]
  3. Boshoff, C. & Weiss, R. A. ( 2001; ). Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus. Philos Trans R Soc Lond Ser B Biol Sci 356, 517–534.[CrossRef]
    [Google Scholar]
  4. Chmielewicz, B., Goltz, M. & Ehlers, B. ( 2001; ). Detection and multigenic characterization of a novel gammaherpesvirus in goats. Virus Res 75, 87–94.[CrossRef]
    [Google Scholar]
  5. Chmielewicz, B., Goltz, M., Franz, T. & 8 other authors ( 2003a; ). A novel porcine gammaherpesvirus. Virology 308, 317–329.[CrossRef]
    [Google Scholar]
  6. Chmielewicz, B., Goltz, M., Lahrmann, K. H. & Ehlers, B. ( 2003b; ). Approaching virus safety in xenotransplantation: a search for unrecognized herpesviruses in pigs. Xenotransplantation 10, 349–356.[CrossRef]
    [Google Scholar]
  7. Crawford, T. B., O'Toole, D. & Li, H. ( 1998; ). Malignant catarrhal fever. In Current Veterinary Therapy IV: Food Animal Practice, pp. 306–309. Edited by J. L. Howard. Philadelphia: W. B. Saunders.
  8. Eberle, R. & Hilliard, J. ( 1995; ). The simian herpesviruses. Infect Agents Dis 4, 55–70.
    [Google Scholar]
  9. Ehlers, B., Borchers, K., Grund, C., Frölich, K., Ludwig, H. & Buhk, H.-J. ( 1999a; ). Detection of new DNA polymerase genes of known and potentially novel herpesviruses by PCR with degenerate and deoxyinosine-substituted primers. Virus Genes 18, 211–220.[CrossRef]
    [Google Scholar]
  10. Ehlers, B., Ulrich, S. & Goltz, M. ( 1999b; ). Detection of two novel porcine herpesviruses with high similarity to gammaherpesviruses. J Gen Virol 80, 971–978.
    [Google Scholar]
  11. Ehlers, B., Ochs, A., Leendertz, F., Goltz, M., Boesch, C. & Mätz-Rensing, K. ( 2003; ). Novel simian homologues of Epstein–Barr virus. J Virol 77, 10695–10699.[CrossRef]
    [Google Scholar]
  12. Felsenstein, J. ( 1996; ). phylip (phylogeny inference package) version 3.5. Department of Genetics, University of Washington, Seattle.
  13. Ferry, J. A. & Harris, N. L. ( 1994; ). Lymphoproliferative disorders following organ transplantation. Adv Pathol Lab Med 7, 359–387.
    [Google Scholar]
  14. Fishman, J. A. ( 1994; ). Miniature swine as organ donors for man: strategies for prevention of xenotransplant-associated infections. Xenotransplantation 1, 47–57.[CrossRef]
    [Google Scholar]
  15. Goltz, M., Widen, F., Banks, M., Belak, S. & Ehlers, B. ( 2000; ). Characterization of the DNA polymerase locus of porcine cytomegaloviruses from diverse geographic origins. Virus Genes 21, 249–255.[CrossRef]
    [Google Scholar]
  16. Goltz, M., Ericcson, T., Huang, C., Patience, C., Sachs, D. H. & Ehlers, B. ( 2002; ). Sequence analysis of the genome of porcine lymphotropic herpesvirus 1 and gene expression during post-transplant lymphoproliferative disease of pigs. Virology 294, 383–393.[CrossRef]
    [Google Scholar]
  17. Heuschele, W. P. ( 1988; ). Malignant catarrhal fever: a review of a serious disease hazard for exotic and domestic ruminants. Zool Garten NF 58, 123–133.
    [Google Scholar]
  18. Huang, C. A., Fuchimoto, Y., Gleit, Z. L. & 10 other authors ( 2001; ). Posttransplantation lymphoproliferative disease in miniature swine after allogeneic hematopoietic cell transplantation: similarity to human PTLD and association with a porcine gammaherpesvirus. Blood 97, 1467–1473.[CrossRef]
    [Google Scholar]
  19. O'Connell, P., Cunningham, A. & d'Appice, A. J. F. ( 2000; ). Xenotransplantation: its problems and potential as a clinical procedure. Transplant Rev 14, 18–40.[CrossRef]
    [Google Scholar]
  20. Onions, D., Cooper, D. K. C., Alexander, T. J. L. & 9 other authors ( 2000; ). An approach to the control of disease transmission in pig-to-human xenotransplantation. Xenotransplantation 7, 143–155.[CrossRef]
    [Google Scholar]
  21. Regamey, N., Tamm, M., Wernli, M., Witschi, A., Thiel, G., Cathomas, G. & Erb, P. ( 1998; ). Transmission of human herpesvirus 8 infection from renal-transplant donors to recipients. N Engl J Med 339, 1358–1363.[CrossRef]
    [Google Scholar]
  22. Reid, H. W. & Buxton, D. ( 1989; ). Malignant catarrhal fever and the Gammaherpesvirinae of Bovidae. In Herpesvirus Diseases of Cattle, Horses and Pigs, pp. 116–162. Edited by G. Wittmann. Boston: Kluwer.
  23. Schmidt, H. A., Strimmer, K., Vingron, M. & von Haeseler, A. ( 2000; ). tree-puzzle 5.0. Maximum likelihood analysis for nucleotide, amino acid, and two-state data.
  24. Schultz, T. F. ( 1998; ). Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8). J Gen Virol 79, 1573–1591.
    [Google Scholar]
  25. Tucker, A., Belcher, C., Moloo, B., Bell, J., Mazzulli, T., Humar, A., Hughes, A., McArdle, P. & Talbot, A. ( 2002; ). The production of transgenic pigs for potential use in clinical xenotransplantation: microbiological evaluation. Xenotransplantation 9, 191–202.[CrossRef]
    [Google Scholar]
  26. Ulrich, S., Goltz, M. & Ehlers, B. ( 1999; ). Characterization of the DNA polymerase loci of the novel porcine lymphotropic herpesviruses 1 and 2 in domestic and feral pigs. J Gen Virol 80, 3199–3205.
    [Google Scholar]
  27. van Zanten, J., de Leij, L., Prop, J., Harmsen, M. C. & The, T. H. ( 1998; ). Human cytomegalovirus: a viral complication in transplantation. Clin Transplant 12, 145–158.
    [Google Scholar]
  28. Zimmermann, W., Broll, H., Ehlers, B., Buhk, H.-J., Rosenthal, A. & Goltz, M. ( 2001; ). Genome sequence of bovine herpesvirus 4, a bovine rhadinovirus, and identification of an origin of DNA replication. J Virol 75, 1186–1194.[CrossRef]
    [Google Scholar]
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