1887

Abstract

Semliki Forest virus (SFV) infection of the laboratory mouse provides a well-characterized tractable system to study the pathogenesis of virus encephalitis and virus induced demyelination. In μMT mice, which have no antibodies, infectious virus persisted in both the serum and the brain for several weeks, indicating that antibodies are required to eliminate infectious virus. In immunocompetent mice, virus infectivity in the brain was undetectable after the first week of infection, but virus RNA levels declined slowly. Following SFV infection, lesions of demyelination were present in the brains of both immunocompetent and μMT mice, indicating that antibodies are not required to generate lesions of demyelination.

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2008-10-01
2019-09-20
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vol. , part 10, pp. 2565 - 2568

Luxol fast blue stained 5 µm paraffin sections counterstained with cresyl fast violet [PDF](103 KB)



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