RT Journal Article SR Electronic(1) A1 Chaturvedi, Anil K. A1 Brinkman, Joeli A. A1 Gaffga, Ann M. A1 Dumestre, Jeanne A1 Clark, Rebecca A. A1 Braly, Patricia S. A1 Dunlap, Kathleen A1 Kissinger, Patricia J. A1 Hagensee, Michael E.YR 2004 T1 Distribution of human papillomavirus type 16 variants in human immunodeficiency virus type 1-positive and -negative women JF Journal of General Virology, VO 85 IS 5 SP 1237 OP 1241 DO https://doi.org/10.1099/vir.0.19694-0 PB Microbiology Society, SN 1465-2099, AB The prevalence of human papillomavirus type 16 E6 variant lineages was characterized in a cross-sectional study of 24 human immunodeficiency virus type 1 (HIV)-positive and 33 HIV-negative women in New Orleans. The European prototype was the predominant variant in the HIV-negative women (39·4 %), while in the HIV-positive women the European 350G variant was predominant (29·1 %). In exact logistic regression models, HIV-positive women were significantly more likely to harbour any variant with a nucleotide G-350 mutation compared with HIV-negative women [58·3 % vs 21·1 %; adjusted odds ratio (AOR)=6·28, 95 % confidence interval (CI)=1·19–46·54]. Models also revealed a trend towards increased prevalence of Asian–American lineage in HIV-positive women compared with HIV-negative women (25·0 % vs 6·0 %; AOR=6·35, 95 % CI=0·77–84·97). No association was observed between any variant and cytology or CD4 cell counts or HIV-1 viral loads. These observations reflect a difference in the distribution of HPV-16 variants among HIV-positive and -negative women, indicating that HIV-positive status may lead to increased prevalence of a subset of variants., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.19694-0