1887

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Volume 85, Issue 5

Distribution of human papillomavirus type 16 variants in human immunodeficiency virus type 1-positive and -negative women Free

Abstract

The prevalence of human papillomavirus type 16 E6 variant lineages was characterized in a cross-sectional study of 24 human immunodeficiency virus type 1 (HIV)-positive and 33 HIV-negative women in New Orleans. The European prototype was the predominant variant in the HIV-negative women (39·4 %), while in the HIV-positive women the European 350G variant was predominant (29·1 %). In exact logistic regression models, HIV-positive women were significantly more likely to harbour any variant with a nucleotide G-350 mutation compared with HIV-negative women [58·3 % vs 21·1 %; adjusted odds ratio (AOR)=6·28, 95 % confidence interval (CI)=1·19–46·54]. Models also revealed a trend towards increased prevalence of Asian–American lineage in HIV-positive women compared with HIV-negative women (25·0 % vs 6·0 %; AOR=6·35, 95 % CI=0·77–84·97). No association was observed between any variant and cytology or CD4 cell counts or HIV-1 viral loads. These observations reflect a difference in the distribution of HPV-16 variants among HIV-positive and -negative women, indicating that HIV-positive status may lead to increased prevalence of a subset of variants.

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2004-05-01
2024-04-25
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References

  1. Ahdieh L., Klein R. S., Burk R. 7 other authors 2001; Prevalence, incidence, and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative women. J Infect Dis 184:682–690
     [Google Scholar]
  2. Andersson S., Alemi M., Rylander E., Strand A., Larsson B., Sallstrom J., Wilander E. 2000; Uneven distribution of HPV 16 E6 prototype and variant (L83V) oncoprotein in cervical neoplastic lesions. Br J Cancer 83:307–310
     [Google Scholar]
  3. Berumen J., Ordonez R. M., Lazcano E. 7 other authors 2001; Asian–American variants of human papillomavirus 16 and risk for cervical cancer: a case–control study. J Natl Cancer Inst 93:1325–1330
     [Google Scholar]
  4. Bosch F. X., Manos M. M., Munoz N. 7 other authors 1995; Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group. J Natl Cancer Inst 87:796–802
     [Google Scholar]
  5. Castellsague X., Bosch F. X., Munoz N. 2002; Environmental co-factors in HPV carcinogenesis. Virus Res 89:191–199
     [Google Scholar]
  6. Da Costa M. M., Hogeboom C. J., Holly E. A., Palefsky J. M. 2002; Increased risk of high-grade anal neoplasia associated with a human papillomavirus type 16 E6 sequence variant. J Infect Dis 185:1229–1237
     [Google Scholar]
  7. Ellis J. R., Keating P. J., Baird J. 7 other authors 1995; The association of an HPV16 oncogene variant with HLA-B7 has implications for vaccine design in cervical cancer. Nat Med 1:464–470
     [Google Scholar]
  8. Giannoudis A., Herrington C. S. 2001; Human papillomavirus variants and squamous neoplasia of the cervix. J Pathol 193:295–302
     [Google Scholar]
  9. Gravitt P. E., Peyton C. L., Apple R. J., Wheeler C. M. 1998; Genotyping of 27 human papillomavirus types by using L1 consensus PCR products by a single-hybridization, reverse line blot detection method. J Clin Microbiol 36:3020–3027
     [Google Scholar]
  10. Hildesheim A., Wang S. S. 2002; Host and viral genetics and risk of cervical cancer: a review. Virus Res 89:229–240
     [Google Scholar]
  11. Hildesheim A., Herrero R., Castle P. E. 13 other authors 2001a; HPV co-factors related to the development of cervical cancer: results from a population-based study in Costa Rica. Br J Cancer 84:1219–1226
     [Google Scholar]
  12. Hildesheim A., Schiffman M., Bromley C. & 12 other authors (2001b). Human papillomavirus type 16 variants and risk of cervical cancer. J Natl Cancer Inst 93:315–318
     [Google Scholar]
  13. Icenogle J. P., Laga M., Miller D., Manoka A. T., Tucker R. A., Reeves W. C. 1992; Genotypes and sequence variants of human papillomavirus DNAs from human immunodeficiency virus type 1-infected women with cervical intraepithelial neoplasia. J Infect Dis 166:1210–1216
     [Google Scholar]
  14. Kammer C., Tommasino M., Syrjanen S., Delius H., Hebling U., Warthorst U., Pfister H., Zehbe I. 2002; Variants of the long control region and the E6 oncogene in European human papillomavirus type 16 isolates: implications for cervical disease. Br J Cancer 86:269–273
     [Google Scholar]
  15. Londesborough P., Ho L., Terry G., Cuzick J., Wheeler C., Singer A. 1996; Human papillomavirus genotype as a predictor of persistence and development of high-grade lesions in women with minor cervical abnormalities. Int J Cancer 69:364–368
     [Google Scholar]
  16. Lorincz A. T., Reid R., Jenson A. B., Greenberg M. D., Lancaster W., Kurman R. J. 1992; Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital types. Obstet Gynecol 79:328–337
     [Google Scholar]
  17. Lorincz A. T., Castle P. E., Sherman M. E. 7 other authors 2002; Viral load of human papillomavirus and risk of CIN3 or cervical cancer. Lancet 360:228–229
     [Google Scholar]
  18. Maciag P. C., Villa L. L. 1999; Genetic susceptibility to HPV infection and cervical cancer. Braz J Med Biol Res 32:915–922
     [Google Scholar]
  19. Mehta C. R., Patel N. R. 1995; Exact logistic regression: theory and examples. Stat Med 14:2143–2160
     [Google Scholar]
  20. Minkoff H., Feldman J., DeHovitz J., Landesman S., Burk R. 1998; A longitudinal study of human papillomavirus carriage in human immunodeficiency virus-infected and human immunodeficiency virus-uninfected women. Am J Obstet Gynecol 178:982–986
     [Google Scholar]
  21. Moreno V., Munoz N., Bosch F. X. 7 other authors 1995; Risk factors for progression of cervical intraepithelial neoplasm grade III to invasive cervical cancer. Cancer Epidemiol Biomarkers Prev 4:459–467
     [Google Scholar]
  22. Munoz N., Bosch F. X., de Sanjose S. 7 other authors 1992; The causal link between human papillomavirus and invasive cervical cancer: a population-based case–control study in Colombia and Spain. Int J Cancer 52:743–749
     [Google Scholar]
  23. Munoz N., Bosch F. X., de Sanjose S., Herrero R., Castellsague X., Shah K. V., Snijders P. J., Meijer C. J. 2003; Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 348:518–527
     [Google Scholar]
  24. Palefsky J. M., Minkoff H., Kalish L. A. 7 other authors 1999; Cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women. J Natl Cancer Inst 91:226–236
     [Google Scholar]
  25. Perez-Gallego L., Moreno-Bueno G., Sarrio D., Suarez A., Gamallo C., Palacios J. 2001; Human papillomavirus-16 E6 variants in cervical squamous intraepithelial lesions from HIV-negative and HIV-positive women. Am J Clin Pathol 116:143–148
     [Google Scholar]
  26. Stoppler M. C., Ching K., Stoppler H., Clancy K., Schlegel R., Icenogle J. 1996; Natural variants of the human papillomavirus type 16 E6 protein differ in their abilities to alter keratinocyte differentiation and to induce p53 degradation. J Virol 70:6987–6993
     [Google Scholar]
  27. Sun X. W., Kuhn L., Ellerbrock T. V., Chiasson M. A., Bush T. J., Wright T. C. Jr 1997; Human papillomavirus infection in women infected with the human immunodeficiency virus. N Engl J Med 337:1343–1349
     [Google Scholar]
  28. Ting Y., Manos M. M. 1990; Detection and typing of genital human papillomaviruses. In PCR Protocols: a Guide to Methods and Applications pp  356–367 Edited by Innis M., Gelfand D., Sninsky J., White T. San Diego, CA: Academic Press;
     [Google Scholar]
  29. van Belkum A., Juffermans L., Schrauwen L., van Doornum G., Burger M., Quint W. 1995; Genotyping human papillomavirus type 16 isolates from persistently infected promiscuous individuals and cervical neoplasia patients. J Clin Microbiol 33:2957–2962
     [Google Scholar]
  30. Vernon S. D., Reeves W. C., Clancy K. A., Laga M., St Louis M., Gary H. E. Jr, Ryder R. W., Manoka A. T., Icenogle J. P. 1994; A longitudinal study of human papillomavirus DNA detection in human immunodeficiency virus type 1-seropositive and -seronegative women. J Infect Dis 169:1108–1112
     [Google Scholar]
  31. Walboomers J. M., Jacobs M. V., Manos M. M. 7 other authors 1999; Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189:12–19
     [Google Scholar]
  32. Welters M. J., de Jong A., van den Eeden S. J. 10 other authors 2003; Frequent display of human papillomavirus type 16 E6-specific memory T-helper cells in the healthy population as witness of previous viral encounter. Cancer Res 63:636–641
     [Google Scholar]
  33. Xi L. F., Koutsky L. A., Galloway D. A., Kuypers J., Hughes J. P., Wheeler C. M., Holmes K. K., Kiviat N. B. 1997; Genomic variation of human papillomavirus type 16 and risk for high grade cervical intraepithelial neoplasia. J Natl Cancer Inst 89:796–802
     [Google Scholar]
  34. Xi L. F., Critchlow C. W., Wheeler C. M. 9 other authors 1998; Risk of anal carcinoma in situ in relation to human papillomavirus type 16 variants. Cancer Res 58:3839–3844
     [Google Scholar]
  35. Xi L. F., Carter J. J., Galloway D. A. Kuypers J., Hughes J. P., Lee S. K., Adam D.E., Kiviat N. B., Koutsky L. A. 2002; Acquisition and natural history of human papillomavirus type 16 variant infection among a cohort of female university students. Cancer Epidemiol Biomarkers Prev 11:343–351
     [Google Scholar]
  36. Yamada T., Wheeler C. M., Halpern A. L., Stewart A. C., Hildesheim A., Jenison S. A. 1995; Human papillomavirus type 16 variant lineages in United States populations characterized by nucleotide sequence analysis of the E6, L2, and L1 coding segments. J Virol 69:7743–7753
     [Google Scholar]
  37. Yamada T., Manos M. M., Peto J., Greer C. E., Munoz N., Bosch F. X., Wheeler C. M. 1997; Human papillomavirus type 16 sequence variation in cervical cancers: a worldwide perspective. J Virol 71:2463–2472
     [Google Scholar]
  38. Zehbe I., Wilander E., Delius H., Tommasino M. 1998; Human papillomavirus 16 E6 variants are more prevalent in invasive cervical carcinoma than the prototype. Cancer Res 58:829–833
     [Google Scholar]
  39. Zehbe I., Voglino G., Wilander, Delius H., Marongiu A., Edler L., Klimek F., Andersson S., Tommasino M. 2001; p53 codon 72 polymorphism and various human papillomavirus 16 E6 genotypes are risk factors for cervical cancer development. Cancer Res 61:608–611
     [Google Scholar]
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Distribution of human papillomavirus type 16 variants in human immunodeficiency virus type 1-positive and -negative women
J. Gen. Virol. 85, 1237 (2004); https://doi.org/10.1099/vir.0.19694-0
/content/journal/jgv/10.1099/vir.0.19694-0
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