1887

Abstract

Knowledge of virus genes under positive selection pressure can help identify molecular determinants of species-specific virulence or host range without prior knowledge of the mechanisms governing host range and virulence. Towards this end, codon-based models of substitution were used in a maximum-likelihood approach to analyse selection pressures acting on 83 genes of group I nucleopolyhedroviruses (NPVs). Evidence for positive selection was found for nine genes: , , , , , , , and . The baculovirus DNA helicase gene () was not found to be positively selected using models that allowed the intensity of selection pressure to vary among codon sites. Further analysis with a method that allows selection pressure intensity to vary among lineages suggests that positive selection may have occurred in during the divergence of NPV and the NPVs of and . NPV genes that have undergone positive selection may modulate the ability of different NPVs to replicate efficiently in cells (, , ) or to establish primary infection of the midgut (, ) of different host species.

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2004-01-01
2019-12-08
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