RT Journal Article SR Electronic(1) A1 Costa-Mattioli, Mauro A1 Napoli, Anna Di A1 Ferré, Virginie A1 Billaudel, Sylviane A1 Perez-Bercoff, Raul A1 Cristina, JuanYR 2003 T1 Genetic variability of hepatitis A virus JF Journal of General Virology, VO 84 IS 12 SP 3191 OP 3201 DO https://doi.org/10.1099/vir.0.19532-0 PB Microbiology Society, SN 1465-2099, AB Knowledge of the molecular biology of hepatitis A virus (HAV) has increased exponentially since its identification. HAV exploits all known mechanisms of genetic variation to ensure survival, including mutation and genetic recombination. HAV has been characterized by the emergence of different genotypes, three human antigenic variants and only one major serotype. This paper reviews the genetic variability and molecular epidemiology of HAV. Its evolutionary mechanisms are described with particular emphasis on genetic recombination and HAV mutation rate. Genotypic classification methods are also discussed., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.19532-0