1887

Abstract

The complete nucleotide sequences of three human echovirus (EV) 11 strains and one EV19 strain, all of which caused outbreaks of enterovirus uveitis (EU), a new infant disease first identified in 1980 in Siberia, were determined. One EV11 strain which caused an outbreak of sepsis-like disease in Hungary was also sequenced. All four EV11 strains were mosaic recombinants of the prototype EV11 strain Gregory, with their non-structural coding regions and 5′ NTRs being more similar to other prototype enteroviruses (EV1, EV9). However, this finding is probably a feature of all circulating enterovirus strains and may not be related to their altered virulence. A full genome sequence comparison of the three subtypes of EU-causing strains excludes the role of recent recombination in their emergence, and points to their independent emergence.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.19469-0
2004-02-01
2019-11-14
Loading full text...

Full text loading...

/deliver/fulltext/jgv/85/2/vir850463.html?itemId=/content/journal/jgv/10.1099/vir.0.19469-0&mimeType=html&fmt=ahah

References

  1. Agol, V. I. ( 2002; ). Genome instability in picornaviruses. Mol Biol (Mosc) 36, 286–295.
    [Google Scholar]
  2. Andersson, P., Edman, K. & Lindberg, A. M. ( 2002; ). Molecular analysis of the echovirus 18 prototype: evidence of interserotypic recombination with echovirus 9. Virus Res 85, 71–83.[CrossRef]
    [Google Scholar]
  3. Brown, B. A., Oberste, S., Alexander, J. P., Kennett, M. L. & Pallansch, M. A. ( 1999; ). Molecular epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998. J Virol 73, 9969–9975.
    [Google Scholar]
  4. Chang, K. H., Auvinen, P., Hyypiä, T. & Stanway, G. ( 1989; ). The nucleotide sequence of coxsackievirus A9; implications for receptor binding and enterovirus classification. J Gen Virol 70, 3269–3280.[CrossRef]
    [Google Scholar]
  5. Chua, B. H., McMinn, P. C., Lam, S. K. & Chua, K. B. ( 2001; ). Comparison of the complete nucleotide sequence of echovirus 7 strain UMMC and the prototype (Wallace) strain demonstrates a significant genetic drift over time. J Gen Virol 82, 2629–2639.
    [Google Scholar]
  6. Dahllund, L., Nissinen, L., Pulli, T., Hyttinen, V., Stanway, G. & Hyypia, T. ( 1995; ). The genome of echovirus 11. Virus Res 35, 215–222.[CrossRef]
    [Google Scholar]
  7. El-Sageyer, M., Szendroi, A., Hutter, E. & 12 other authors ( 1998; ). Characterisation of an echovirus type 11′ epidemic strain causing haemorrhagic syndrome in newborn babies in Hungary. Acta Virol 42, 157–166.
    [Google Scholar]
  8. Felsenstein, J. ( 1989; ). phylip – Phylogeny Inference Package (Version 3.2). Cladistics 5, 164–166.
    [Google Scholar]
  9. Gratsch, T. E. & Righthand, V. F. ( 1994; ). Construction of a recombinant cDNA of echovirus 6 that established a persistent in vitro infection. Virology 201, 341–348.[CrossRef]
    [Google Scholar]
  10. Iizuka, N., Kuge, S. & Nomoto, A. ( 1987; ). Complete nucleotide sequence of the genome of coxsackievirus B1. Virology 156, 64–73.[CrossRef]
    [Google Scholar]
  11. Jenkins, O., Booth, J. D., Minor, P. D. & Almond, J. W. ( 1987; ). The complete nucleotide sequence of coxsackievirus B4 and its comparison to other members of the Picornaviridae. J Gen Virol 68, 1835–1848.[CrossRef]
    [Google Scholar]
  12. Klump, W. M., Bergmann, I., Muller, B. C., Ameis, D. & Kandolf, R. ( 1990; ). Complete nucleotide sequence of infectious coxsackievirus B3 cDNA: two initial 5′ uridine residues are regained during plus-strand RNA synthesis. J Virol 64, 1573–1583.
    [Google Scholar]
  13. Koroleva, G., Lashkevich, V., Denisova, E., Tereshkina, N., Khoroshilova-Maslova, I., Katargina, L., Lukashev, A., Krichevskaya, G. & Khvatova, A. ( 1998; ). Enteroviral persistence in eye infections in monkeys (postuveitis syndrome). Vopr Virusol 43, 204–216.
    [Google Scholar]
  14. Lashkevich, V., Koroleva, G., Tereshkina, N., Lukashev, A., Grigoryeva, L. & Titova, I. ( 1996; ). Superacute lethal necrosis of the liver in monkeys infected with high-pathogenic variants of enteroviruses (ECHO 11 and ECHO 19). Vopr Virusol 41, 198–206.
    [Google Scholar]
  15. Lindberg, A. M., Johansson, S. & Andersson, A. ( 1999; ). Echovirus 5: infectious transcripts and complete nucleotide sequence from uncloned cDNA. Virus Res 59, 75–87.[CrossRef]
    [Google Scholar]
  16. Lindberg, M. A., Andersson, P., Savolainen, C., Mulders, M. N. & Hovi, T. ( 2003; ). Evolution of the genome of human enterovirus B: incongruence between phylogenies of the VP1 and 3CD regions indicates frequent recombination within the species. J Gen Virol 84, 1223–1235.[CrossRef]
    [Google Scholar]
  17. Lukashev, A. N., Lashkevich, V. A., Koroleva, G. A. & Karganova, G. G. ( 2002; ). Phylogenetic and serological characterization of echovirus 11 and echovirus 19 strains causing uveitis. Arch Virol 147, 131–142.[CrossRef]
    [Google Scholar]
  18. Lukashev, A. N., Lashkevich, V. A., Ivanova, O. E., Koroleva, G. A., Hinkkanen, A. E. & Ilonen, J. ( 2003a; ). Recombination in circulating enteroviruses. J Virol 77, 10423–10431.[CrossRef]
    [Google Scholar]
  19. Lukashev, A. N., Lashkevich, V. A., Koroleva, G. A., Ilonen, J., Karganova, G. G., Reznik, V. I. & Hinkkanen, A. E. ( 2003b; ). Molecular epidemiology of enteroviruses causing uveitis and multisystem hemorrhagic disease of infants. Virology 307, 45–53.[CrossRef]
    [Google Scholar]
  20. Martino, T. A., Tellier, R., Petric, M., Irwin, D. M., Afshar, A. & Liu, P. P. ( 1999; ). The complete consensus sequence of coxsackievirus B6 and generation of infectious clones by long RT-PCR. Virus Res 64, 77–86.[CrossRef]
    [Google Scholar]
  21. Muir, P., Kammerer, U., Korn, K., Mulders, M. N., Poyry, T., Weissbrich, B., Kandolf, R., Cleator, G. M. & van Loon, A. M. ( 1998; ). Molecular typing of enteroviruses: current status and future requirements. The European Union Concerned Action on Virus Meningitis and Encephalitis. Clin Microbiol Rev 11, 202–227.
    [Google Scholar]
  22. Oberste, M. S., Maher, K., Kilpatrick, D. R., Flemister, M. R., Brown, B. A. & Pallansch, M. A. ( 1999; ). Typing of human enteroviruses by partial sequencing of VP1. J Clin Microbiol 37, 1288–1293.
    [Google Scholar]
  23. Oprisan, G., Combiescu, M., Guillot, S., Caro, V., Combiescu, A., Delpeyroux, F. & Crainic, R. ( 2002; ). Natural genetic recombination between co-circulating heterotypic enteroviruses. J Gen Virol 83, 2193–2200.
    [Google Scholar]
  24. Pallansch, M. A. & Roos, R. P. ( 2001; ). Enteroviruses: polioviruses, coxsackieviruses, echoviruses and newer enteroviruses. In Fields Virology, 4th edn, pp. 723–775. Edited by D. M. Knipe & P. M. Howley. Philadelphia: Lippincott Williams & Wilkins.
  25. Racaniello, V. R. ( 2001; ). Picornaviridae: the viruses and their replication. In Fields Virology, 4th edn, pp. 685–723. Edited by D. M. Knipe & P. M. Howley. Philadelphia: Lippincott Williams & Wilkins.
  26. Robertson, D. L., Hahn, B. H. & Sharp, P. M. ( 1995; ). Recombination in AIDS viruses. J Mol Evol 40, 249–259.[CrossRef]
    [Google Scholar]
  27. Salminen, M. O., Carr, J. K., Burke, D. S. & McCutchan, F. E. ( 1995; ). Identification of breakpoints in intergenotypic recombinants of HIV type 1 by bootscanning. AIDS Res Hum Retroviruses 11, 1423–1425.[CrossRef]
    [Google Scholar]
  28. Santti, J., Hyypia, T., Kinnunen, L. & Salminen, M. ( 1999; ). Evidence of recombination among enteroviruses. J Virol 73, 8741–8749.
    [Google Scholar]
  29. Santti, J., Harvala, H., Kinnunen, L. & Hyypia, T. ( 2000; ). Molecular epidemiology and evolution of coxsackievirus A9. J Gen Virol 81, 1361–1372.
    [Google Scholar]
  30. Sawyer, S. A. ( 1989; ). Statistical tests for detecting gene conversion. Mol Biol Evol 6, 526–538.
    [Google Scholar]
  31. Takeda, N., Tanimura, M. & Miymura, K. ( 1994; ). Molecular evolution of the major capsid protein VP1 of enterovirus 70. J Virol 68, 854–862.
    [Google Scholar]
  32. Thompson, J., Gibson, T., Plewniak, F., Jeanmougin, F. & Higgins, D. ( 1997; ). The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 24, 4876–4882.
    [Google Scholar]
  33. Ward, C. D. & Flanegan, J. B. ( 1992; ). Determination of the poliovirus RNA polymerase error frequency at eight sites in the viral genome. J Virol 66, 3784–3793.
    [Google Scholar]
  34. Zhang, G., Wilsden, G., Knowles, N. J. & McCauley, J. W. ( 1993; ). Complete nucleotide sequence of a coxsackie B5 virus and its relationship to swine vesicular disease virus. J Gen Virol 74, 845–853.[CrossRef]
    [Google Scholar]
  35. Zimmermann, H., Eggers, H. J. & Nelsen-Salz, B. ( 1996; ). Molecular cloning and sequence determination of the complete genome of the virulent echovirus 9 strain Barty. Virus Genes 12, 149–154.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.19469-0
Loading
/content/journal/jgv/10.1099/vir.0.19469-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error