%0 Journal Article %A Denesvre, Caroline %A Soubieux, Denis %A Pin, Gaelle %A Hue, Dominique %A Dambrine, Ginette %T Interference between avian endogenous ev/J 4.1 and exogenous ALV-J retroviral envelopes %D 2003 %J Journal of General Virology, %V 84 %N 12 %P 3233-3238 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.19381-0 %I Microbiology Society, %X A new family of avian retroviral endogenous sequences designated ev/J or EAV-HP has been identified recently. Here an additional avian ev/J 4.1 endogenous sequence, ev/J 4.1 Rb, is reported. ev/J 4.1 Rb has the most extensive amino acid identity ever described for an endogenous envelope protein with the ALV-J avian leukosis virus. Here, we also demonstrate that ev/J 4.1 Rb functionally pseudotypes murine leukaemia virions and leads to a complete reciprocal interference with ALV-J envelopes. This is the first demonstration of such a high level of envelope interference between endogenous and exogenous avian retroviruses. Our results provide additional clues on the co-evolution of retroviral sequences among vertebrates. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.19381-0