@article{mbs:/content/journal/jgv/10.1099/vir.0.19180-0, author = "Magiorkinis, Gkikas and Paraskevis, Dimitrios and Vandamme, Anne-Mieke and Magiorkinis, Emmanouil and Sypsa, Vana and Hatzakis, Angelos", title = "In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: determination of hot spots and correlation with sequence similarity", journal= "Journal of General Virology", year = "2003", volume = "84", number = "10", pages = "2715-2722", doi = "https://doi.org/10.1099/vir.0.19180-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.19180-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Recombination plays a pivotal role in the evolutionary process of many different virus species, including retroviruses. Analysis of all human immunodeficiency virus type 1 (HIV-1) intersubtype recombinants revealed that they are more complex than described initially. Recombination frequency is higher within certain genomic regions, such as partial reverse transcriptase (RT), vif/vpr, the first exons of tat/rev, vpu and gp41. A direct correlation was observed between recombination frequency and sequence similarity across the HIV-1 genome, indicating that sufficient sequence similarity is required upstream of the recombination breakpoint. This finding suggests that recombination in vivo may occur preferentially during reverse transcription through the strand displacement-assimilation model rather than the copy-choice model.", }