@article{mbs:/content/journal/jgv/10.1099/vir.0.19053-0, author = "Bigger, John E. and Martin, David W.", title = "The genome of herpesvirus papio 2 is closely related to the genomes of human herpes simplex viruses", journal= "Journal of General Virology", year = "2003", volume = "84", number = "6", pages = "1411-1414", doi = "https://doi.org/10.1099/vir.0.19053-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.19053-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Infection of baboons (Papio species) with herpesvirus papio 2 (HVP-2) produces a disease that is clinically similar to herpes simplex virus (HSV-1 and HSV-2) infection of humans. The development of a primate model of simplexvirus infection based on HVP-2 would provide a powerful resource to study virus biology and test vaccine strategies. In order to characterize the molecular biology of HVP-2 and justify further development of this model system we have constructed a physical map of the HVP-2 genome. The results of these studies have identified the presence of 26 reading frames that closely resemble HSV homologues. Furthermore, the HVP-2 genome shares a collinear arrangement with the genome of HSV. These studies further validate the development of the HVP-2 model as a surrogate system to study the biology of HSV infections.", }