1887

Abstract

Infection of baboons ( species) with herpesvirus papio 2 (HVP-2) produces a disease that is clinically similar to herpes simplex virus (HSV-1 and HSV-2) infection of humans. The development of a primate model of simplexvirus infection based on HVP-2 would provide a powerful resource to study virus biology and test vaccine strategies. In order to characterize the molecular biology of HVP-2 and justify further development of this model system we have constructed a physical map of the HVP-2 genome. The results of these studies have identified the presence of 26 reading frames that closely resemble HSV homologues. Furthermore, the HVP-2 genome shares a collinear arrangement with the genome of HSV. These studies further validate the development of the HVP-2 model as a surrogate system to study the biology of HSV infections.

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/content/journal/jgv/10.1099/vir.0.19053-0
2003-06-01
2021-10-25
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References

  1. Bigger J. E., Martin D. W. 2002; Herpesvirus papio 2 (HVP-2) encodes a virion host shutoff function. Virology 304:33–43
    [Google Scholar]
  2. Eberle R., Black D. H., Lipper S., Hilliard J. K. 1995; Herpesvirus papio 2, an SA8-like alpha-herpesvirus of baboons. Arch Virol 140:529–545
    [Google Scholar]
  3. Eberle R., Black D. H., Blewett E. L., White G. L. 1997; Prevalence of herpesvirus papio 2 in baboons and identification of immunogenic viral polypeptides. Lab Anim Sci 47:256–262
    [Google Scholar]
  4. Eberle R., Black D. H., Lehenbauer T. W., White G. L. 1998; Shedding and transmission of baboon herpesvirus papio 2 (HVP2) in a breeding colony. Lab Anim Sci 48:23–28
    [Google Scholar]
  5. Harrington L., Wall L. V., Kelly D. C. 1992; Molecular cloning and physical mapping of the genome of simian herpes B virus and comparison of genome organization with that of herpes simplex virus type 1. J Gen Virol 73:1217–1226
    [Google Scholar]
  6. Levin J. L., Hilliard J. K., Lipper S. L., Butler T. M., Goodwin W. J. 1988; A naturally occurring epizootic of simian agent 8 in the baboon. Lab Anim Sci 38:394–397
    [Google Scholar]
  7. McGeoch D. J., Dalrymple M. A., Davison A. J., Dolan A., Frame M. C., McNab D., Perry L. J., Scott J. E., Taylor P. 1988; The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J Gen Virol 69:1531–1574
    [Google Scholar]
  8. McGeoch D. J., Cook S., Dolan A., Jamieson F. E., Telford E. A. R. 1995; Molecular phylogeny and evolutionary timescale for the family of mammalian herpesviruses. J Mol Biol 247:443–458
    [Google Scholar]
  9. Roizman B. 1979; The structure and isomerization of herpes simplex virus genomes. Cell 16:25–57
    [Google Scholar]
  10. Thomson D., Smith G. 1999; Herpesvirus genome mapping: a rapid generic approach. J Virol Methods 82:1–7
    [Google Scholar]
  11. Umene K. 1998 Herpesvirus: Genetic Variability and Recombination Fukuoka, Japan: Touka Shobo;
    [Google Scholar]
  12. Wagner H. M., Summers W. C. 1978; Structure of the joint region and the termini of the DNA of herpes simplex virus type 1. J Virol 27:374–387
    [Google Scholar]
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