1887

Abstract

The 3′-terminal 853 nt (and the putative 283 aa) sequence of the VP2-encoding gene from 29 field strains of porcine parvovirus (PPV) were determined and compared both to each other and with other published sequences. Sequences were examined using maximum-parsimony and statistical analyses for nucleotide diversity and sequence variability. Among the nucleotide sequences of the PPV field strains, 26 polymorphic sites were encountered; 22 polymorphic sites were detected in the putative amino acid sequence. Mapping polymorphic sites of protein data onto the three-dimensional (3D) structure of PPV VP2 revealed that almost all substitutions were located on the external surface of the viral capsid. Mapping amino acid substitutions to the alignment between PPV VP2 sequences and the 3D structure of canine parvovirus (CPV) capsid, many PPV substitutions were observed to map to regions of recognized antigenicity and/or to contain phenotypically important residues for CPV and other parvoviruses. In spite of the high sequence similarity, genetic analysis has shown the existence of at least two virus lineages among the samples. In conclusion, these results highlight the need for close surveillance on PPV genetic drift, with an assessment of its potential ability to modify the antigenic make-up of the virus.

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2003-06-01
2024-12-05
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References

  1. Baranowski E., Ruiz-Jarabo C. M., Domingo E. 2001; Evolution of cell recognition by viruses. Science 292:1102–1105
    [Google Scholar]
  2. Battilani M., Ciulli S., Tisato E., Prosperi S. 2002; Genetic analysis of canine parvovirus isolates (CPV-2) from dogs in Italy. Virus Res 83:149–157
    [Google Scholar]
  3. Bergeron J., Menezes J., Tijssen P. 1993; Genome organization and mapping of transcription and translation products of the NADL-2 strain of porcine parvovirus. Virology 197:86–98
    [Google Scholar]
  4. Bergeron J., Hébert B., Tijssen P. 1996; Genome organization of the Kresse strain of porcine parvovirus: identification of the allotropic determinant and comparision with those of NADL-2 and field isolates. J Virol 70:2508–2515
    [Google Scholar]
  5. Bok K., Matson D. O., Gomez J. A. 2002; Genetic variation of capsid protein VP7 in genotype g4 human rotavirus strains: simultaneous emergence and spread of different lineages in Argentina. J Clin Microbiol 40:2016–2022
    [Google Scholar]
  6. Chapman M. S., Rossmann M. G. 1993; Structure, sequence, and function correlations among parvoviruses. Virology 194:491–508
    [Google Scholar]
  7. Chapman L. E., Heneine W., Switzer W., Sandstrom P., Folks T. M. 1999; Xenotransplantation: the potential for xenogeneic infections. Transplant Proc 31:909–910
    [Google Scholar]
  8. Choi C. S., Molitor T. W., Joo H. S., Gunther R. 1987; Pathogenicity of a skin isolate of porcine parvovirus in swine fetuses. Vet Microbiol 15:19–29
    [Google Scholar]
  9. Chomczynski P. 1993; A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cells and tissue samples. Biotechniques 15: 532–534, 536–537
    [Google Scholar]
  10. Erdman D. D., Durigon E. L., Wang Q. Y., Anderson L. J. 1996; Genetic diversity of human parvovirus B19: sequence analysis of the VP1/VP2 gene from multiple isolates. J Gen Virol 77:2767–2774
    [Google Scholar]
  11. Fanning T. G., Taubenberger J. K. 1999; Phylogenetically important regions of the influenza A H1 hemagglutinin protein. Virus Res 65:33–42
    [Google Scholar]
  12. Gardiner E. M., Tattersall P. 1988; Evidence that developmentally regulated control of gene expression by a parvoviral allotropic determinant is particle mediated. J Virol 62:1713–1722
    [Google Scholar]
  13. Gilbert D. G. 1995; seqpup, version 0.6f: A biosequence editor and analysis application.
  14. Hall T. A. 1999; bioedit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp Ser 41:95–98
    [Google Scholar]
  15. Heinemann M. B., Fernandes-Matioli F. M., Cortez A., Soares R. M., Sakamoto S. M., Bernardi F., Ito F. H., Madeira A. M., Richtzenhain L. J. 2002; Genealogical analyses of rabies virus strains from Brazil based on N gene alleles. Epidemiol Infect 128:503–511
    [Google Scholar]
  16. Kamstrup S., Langeveld J., Botner A. 8 other authors 1998; Mapping the antigenic structure of porcine parvovirus at the level of peptides. Virus Res 53:163–173
    [Google Scholar]
  17. Kresse J. I., Taylor W. D., Stewart W. W., Eernisse K. A. 1985; Parvovirus infection in pigs with necrotic and vesicle-like lesions. Vet Microbiol 10:525–531
    [Google Scholar]
  18. Li W. H. (editor) 1997; Rates and patterns of nucleotide substitution. In Molecular Evolution Sunderland: Sinauer Associates;
    [Google Scholar]
  19. Maddison W. P., Maddison D. R. 1992 macclade, version 3.03 Sunderland: Sinauer Associates;
    [Google Scholar]
  20. Martyn J. C., Davidson B. E., Studdert M. J. 1990; Nucleotide sequence of feline panleukopenia virus: comparison with canine parvovirus identifies host-specific differences. J Gen Virol 71:2747–2753
    [Google Scholar]
  21. Mengeling W. L., Cutlip R. C. 1975; Pathogenesis of in utero infection: experimental infection of five-week-old porcine fetuses with porcine parvovirus. Am J Vet Res 36:1173–1177
    [Google Scholar]
  22. Mengeling W. L., Pejsak Z., Paul P. S. 1984; Biological assay of attenuated strain NADL-2 and virulent strain NADL-8 of porcine parvovirus. Am J Vet Res 45:2403–2407
    [Google Scholar]
  23. Mengeling W. L., Lager K. M., Vorwald A. C. 2000; The effect of porcine parvovirus and porcine reproductive and respiratory syndrome virus on porcine reproductive performance. Anim Reprod Sci 60:61199–210
    [Google Scholar]
  24. Molitor T. W., Joo H. S., Collett M. S. 1983; Porcine parvovirus: virus purification and structural and antigenic properties of virion polypeptides. J Virol 45:842–854
    [Google Scholar]
  25. Murphy F. A. 1996; The public health risk of animal organ and tissue transplantation into humans. Science 273:746–747
    [Google Scholar]
  26. Nei M. 1982; Evolution of the human races at the genetic level. In Human Genetics A. The Unfolding Genome pp  167–181 Edited by Bone-Tamir B., Cohen T., Goodman R. M. New York: Alan R. Liss;
    [Google Scholar]
  27. Novitsky V., Smith U. R., Gilbert P. 16 other authors 2002; Human immunodeficiency virus type 1 subtype C molecular phylogeny: consensus sequence for an AIDS vaccine design?. J Virol 76:5435–5451
    [Google Scholar]
  28. Parrish C. R. 1991; Mapping specific functions in the capsid structure of canine parvovirus and feline panleukopenia virus using infectious plasmid clones. Virology 183:195–205
    [Google Scholar]
  29. Parrish C. R., Aquadro C. F., Carmichael L. E. 1988; Canine host range and aspecific epitope map along with variant sequences in the capsid protein gene of canine parvovirus and related feline, mink, and racoon parvoviruses. Virology 166:293–307
    [Google Scholar]
  30. Parrish C. R., Aquadro C. F., Strassheim M. L., Evermann J. F., Sgro J. Y., Mohammed H. O. 1991; Rapid antigenic-type replacement and DNA sequence evolution of canine parvovirus. J Virol 65:6544–6552
    [Google Scholar]
  31. Platt J. L. 2000; Zoonosis in xenotransplantation. Transplant Proc 32:1551
    [Google Scholar]
  32. Ránz A. I., Manclus J. J., Diaz-Aroca E., Casal J. I. 1989; Porcine parvovirus: DNA sequence and genome organization. J Gen Virol 70:2541–2553
    [Google Scholar]
  33. Rozas J., Rozas R. 1997; dnasp, version 2.0: a novel software package for extensive molecular population genetics analysis. Comput Appl Biosci 13:307–311
    [Google Scholar]
  34. Sakurai M., Nishimori T., Ushimi C., Nakajima H. 1989; Nucleotide sequence of capsid protein gene of porcine parvovirus. Virus Res 13:79–86
    [Google Scholar]
  35. Sambrook J., Fritsch E. F., Maniatis T. 1989 Molecular Cloning: a Laboratory Manual , 2nd edn. vol 3 Cold Spring Harbor, NY: Cold Spring Harbor Laboratory;
    [Google Scholar]
  36. Servant A., Laperche S., Lallemand F., Marinho V., De Saint Maur G., Meritet J. F., Garbarg-Chenon A. 2002; Genetic diversity within human erythroviruses: identification of three genotypes. J Virol 76:9124–9134
    [Google Scholar]
  37. Simpson A. A., Hebert B., Sullivan G. M., Parrish C. R., Zadori Z., Tijssen P., Rossmann M. G. 2002; The structure of porcine parvovirus: comparison with related viruses. J Mol Biol 315:1189–1198
    [Google Scholar]
  38. Soares R. M., Durigon E. L., Bersano J. G., Richtzenhain L. J. 1999; Detection of porcine parvovirus DNA by the polymerase chain reaction assay using primers to the highly conserved nonstructural protein gene, NS-1. J Virol Methods 78:191–198
    [Google Scholar]
  39. Strassheim M. L., Gruenberg A., Veijalainen P., Sgro J. Y., Parrish C. R. 1994; Two dominant neutralizing antigenic determinants of canine parvovirus are found on the threefold spike of the virus capsid. Virology 198:175–184
    [Google Scholar]
  40. Swofford D. L. 2000 paup*: Phylogenetic analysis using parsimony (*and other methods), version 4.0 Sunderland: Sinauer Associates;
    [Google Scholar]
  41. Tajima F. 1983; Evolutionary relationship of DNA sequences in finite populations. Genetics 105:437–460
    [Google Scholar]
  42. Tajima F. 1993; Measurement of DNA polymorphism. In Mechanisms of Molecular Evolution pp  37–59 Edited by Takahata N., Clark A. G. Sunderland: Sinauer Associates;
    [Google Scholar]
  43. Takeuchi Y. 2000; Risk of zoonosis in xenotransplantation. Transplant Proc 32:2698–2700
    [Google Scholar]
  44. Thompson J. D., Gibson T. J., Plewniak F., Jeanmougin F., Higgins D. G. 1997; The clustal_x windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 25:4876–4882
    [Google Scholar]
  45. Truyen U. 1999; Emergence and recent evolution of canine parvovirus. Vet Microbiol 69:47–50
    [Google Scholar]
  46. Yanagihara R., Nerurkar V. R., Scheirich I. 9 other authors 2002; JC virus genotypes in the western Pacific suggest Asian mainland relationships and virus association with early population movements. Hum Biol 74:473–488
    [Google Scholar]
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