1887

Abstract

The incidence of human cytomegalovirus (CMV) genotype gB2 (UL55) is high in patients with human immunodeficiency virus (HIV) infection in the San Francisco Bay area of California. Virus neutralizing antibody (NAb) to human CMV strain Ad169, a gB2 laboratory strain, was measured prospectively in HIV-infected patients, with CD4 T-lymphocyte counts <200, who were at risk for CMV-associated disease. Patients were grouped according to CMV DNA copy number, as quantified by PCR, and presence or absence of CMV-induced retinitis. Mean NAb titres were similar in all patient groups and unrelated to either virus load or outcome of CMV infection. Both gB2 and mixtures of gB2 with other gB genotypes were represented in isolates from blood and/or urine, even in the presence of high titres of antibody to the gB2 genotype challenge virus.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.18896-0
2003-07-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/84/7/vir841853.html?itemId=/content/journal/jgv/10.1099/vir.0.18896-0&mimeType=html&fmt=ahah

References

  1. Adler S. P., Starr S. E., Plotkin S. A., Hempfling S. H., Buis J., Manning M. L., Best A. M. 1995; Immunity induced by primary human cytomegalovirus infection protects against secondary infection among women of childbearing age. J Infect Dis 171:26–32
    [Google Scholar]
  2. Alberola J., Dominguez V., Cardenoso L. 7 other authors 1998; Antibody response to human cytomegalovirus (HCMV) glycoprotein B (gB) in AIDS patients with HCMV end-organ disease. J Med Virol 55:272–280
    [Google Scholar]
  3. Boppana S. B., Britt W. J. 1995; Antiviral antibody responses and intrauterine transmission after primary maternal cytomegalovirus infection. J Infect Dis 171:1115–1121
    [Google Scholar]
  4. Boppana S. B., Polis M. A., Kramer A. A., Britt W. J., Koenig S. 1995; Virus-specific antibody responses to human cytomegalovirus (HCMV) in human immunodeficiency virus type 1-infected persons with HCMV retinitis. J Infect Dis 171:182–185
    [Google Scholar]
  5. Britt W. J., Vugler L., Butfiloski E. J., Stephens E. B. 1990; Cell surface expression of human cytomegalovirus (HCMV) gp55–116 (gB): use of HCMV-recombinant vaccinia virus-infected cells in analysis of the human neutralizing antibody response. J Virol 64:1079–1085
    [Google Scholar]
  6. Chou S. W. 1986; Acquisition of donor strains of cytomegalovirus by renal-transplant recipients. New Engl J Med 314:1418–1423
    [Google Scholar]
  7. Collier A. C., Chandler S. H., Handsfield H. H., Corey L., McDougall J. K. 1989; Identification of multiple strains of cytomegalovirus in homosexual men. J Infect Dis 159:123–126
    [Google Scholar]
  8. Drew W. L., Sweet E. S., Miner R. C., Mocarski E. S. 1984; Multiple infections by cytomegalovirus in patients with acquired immunodeficiency syndrome: documentation by Southern blot hybridization. J Infect Dis 150:952–953
    [Google Scholar]
  9. Rasmussen L. 1999; Molecular pathogenesis of human cytomegalovirus infection. Transpl Infect Dis 1:127–134
    [Google Scholar]
  10. Rasmussen L. E., Nelson R. M., Kelsall D. C., Merigan T. C. 1984; Murine monoclonal antibody to a single protein neutralizes the infectivity of human cytomegalovirus. Proc Natl Acad Sci U S A 81:876–880
    [Google Scholar]
  11. Rasmussen L., Mullenax J., Nelson R., Merigan T. C. 1985; Viral polypeptides detected by a complement-dependent neutralizing murine monoclonal antibody to human cytomegalovirus. J Virol 55:274–280
    [Google Scholar]
  12. Rasmussen L., Zipeto D., Wolitz R. A., Dowling A., Efron B., Merigan T. C. 1997; Risk for retinitis in patients with AIDS can be assessed by quantitation of threshold levels of cytomegalovirus DNA burden in blood. J Infect Dis 176:1146–1155
    [Google Scholar]
  13. Snydman D. R. 2001; Historical overview of the use of cytomegalovirus hyperimmune globulin in organ transplantation. Transpl Infect Dis 3 (Suppl. 2):6–13
    [Google Scholar]
  14. Urban M., Britt W., Mach M. 1992; The dominant linear neutralizing antibody-binding site of glycoprotein gp86 of human cytomegalovirus is strain specific. J Virol 66:1303–1311
    [Google Scholar]
  15. Zipeto D., Morris S., Hong C., Dowling A., Wolitz R., Merigan T. C., Rasmussen L. 1995; Human cytomegalovirus (CMV) DNA in plasma reflects quantity of CMV DNA present in leukocytes. J Clin Microbiol 33:2607–2611
    [Google Scholar]
  16. Zipeto D., Hong C., Gerna G., Zavattoni M., Katzenstein D., Merigan T. C., Rasmussen L. 1998; Geographic and demographic differences in the frequency of human cytomegalovirus gB genotypes 1–4 in immunocompromised patients. AIDS Res Hum Retroviruses 14:533–536
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.18896-0
Loading
/content/journal/jgv/10.1099/vir.0.18896-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error