1887

Abstract

Immunization via the oral route with an attenuated strain expressing a fragment of the measles virus nucleocapsid protein (aa 79–161) via its type III protein secretion system induced a T helper type 1 response in immunized C3H mice, which conferred protection against measles virus-induced encephalitis in a time- and dose-dependent manner.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.18834-0
2003-04-01
2019-12-05
Loading full text...

Full text loading...

/deliver/fulltext/jgv/84/4/vir840775.html?itemId=/content/journal/jgv/10.1099/vir.0.18834-0&mimeType=html&fmt=ahah

References

  1. Bouche, F. B., Ertl, O. T. & Muller, C. P. ( 2002; ). Neutralizing B cell responses in measles. Viral Immunol 15, 451–472.[CrossRef]
    [Google Scholar]
  2. Fennelly, G. J., Flynn, J. A. L., ter Meulen, V., Liebert, U. G. & Bloom, B. R. ( 1995; ). Recombinant Bacille Calmette-Guerin priming against measles. J Infect Dis 172, 698–705.[CrossRef]
    [Google Scholar]
  3. Finke, D., Brinckmann, U. G., ter Meulen, V. & Liebert, U. G. ( 1995; ). Gamma interferon is a major mediator of the antiviral defense in experimental measles virus-induced encephalitis. J Virol 69, 5469–5474.
    [Google Scholar]
  4. Hilleman, M. R. ( 2001; ). Current overview of the pathogenesis and prophylaxis of measles with focus on practical implications. Vaccine 20, 651–665.[CrossRef]
    [Google Scholar]
  5. Igwe, E. I., Russmann, H., Roggenkamp, A., Noll, A., Autenrieth, I. B. & Heesemann, J. ( 1999; ). Rational live oral carrier vaccine design by mutating virulence-associated genes of Yersinia enterocolitica. Infect Immun 67, 5500–5507.
    [Google Scholar]
  6. Jacobi, C. A., Roggenkamp, A., Rakin, A., Zumbihl, R., Leitritz, L. & Heesemann, J. ( 1998; ). In vitro and in vivo expression studies of yopE from Yersinia enterocolitica using the gfp reporter gene. Mol Microbiol 30, 865–882.[CrossRef]
    [Google Scholar]
  7. Katz, M. ( 1995; ). Clinical spectrum of measles. In Measles Virus, pp. 1–12. Edited by M. Billeter & V. ter Meulen. Berlin: Springer.
  8. Neumeister, C. & Niewiesk, S. ( 1998; ). Recognition of measles virus-infected cells by CD8+ T cells depends on the H-2 molecule. J Gen Virol 79, 2583–2591.
    [Google Scholar]
  9. Niewiesk, S., Brinckmann, U., Bankamp, B., Sirak, S., Liebert, U. G. & ter Meulen, V. ( 1993; ). Susceptibility to measles virus-induced encephalitis in mice correlates with impaired antigen presentation to cytotoxic T lymphocytes. J Virol 67, 75–81.
    [Google Scholar]
  10. Polack, F. P., Auwaerter, P. G., Lee, S.-H., Nousari, H. C., Valsamakis, A., Leiferman, K. M., Diwan, A., Adams, R. J. & Griffin, D. E. ( 1999; ). Production of atypical measles in rhesus macaques: evidence for disease mediated by immune complex formation and eosinophils in the presence of fusion-inhibiting antibody. Nat Med 5, 629–634.[CrossRef]
    [Google Scholar]
  11. Polack, F. P., Hoffman, S. J., Moss, W. J. & Griffin, D. E. ( 2002; ). Altered synthesis of interleukin-12 and type 1 and type 2 cytokinesin rhesus macaques during measles and atypical measles. J Infect Dis 185, 13–19.[CrossRef]
    [Google Scholar]
  12. Reich, A., Erlwein, O., Niewiesk, S., ter Meulen, V. & Liebert, U. G. ( 1992; ). CD4+ T cells control measles virus infection of the central nervous system. Immunology 76, 185–191.
    [Google Scholar]
  13. Roggenkamp, A., Bittner, T., Leitritz, L., Sing, A. & Heesemann, J. ( 1997; ). Contribution of the Mn-cofactored superoxide dismutase (SodA) to the virulence of Yersinia enterocolitica serotype O8. Infect Immun 65, 4705–4710.
    [Google Scholar]
  14. Russmann, H., Weissmuller, A., Geginat, G., Igwe, E. I., Roggenkamp, A., Bubert, A., Goebel, W., Hof, H. & Heesemann, J. ( 2001; ). Yersinia enterocolitica-mediated translocation of defined fusion proteins to the cytosol of mammalian cells results in peptide-specific MHC class I-restricted antigen presentation. Eur J Immunol 30, 1375–1384.
    [Google Scholar]
  15. Schlereth, B., Rose, K. J., Buonocore, L., ter Meulen, V. & Niewiesk, S. ( 2000; ). Successful vaccine-induced seroconversion by single dose immunization in the presence of measles virus specific maternal antibodies. J Virol 74, 4652–4657.[CrossRef]
    [Google Scholar]
  16. Spreng, S., Gentschev, I., Goebel, W., Weidinger, G., ter Meulen, V. & Niewiesk, S. ( 2000; ). Salmonella vaccines secreting measles virus epitopes induce protective immune responses against measles virus encephalitis. Microbes Infect 2, 1687–1692.[CrossRef]
    [Google Scholar]
  17. Tober, C., Seufert, M., Schneider, H., Billeter, M. A., Johnston, I. C. D., Niewiesk, S., ter Meulen, V. & Schneider-Schaulies, S. ( 1998; ). Expression of measles virus V protein is associated with transcriptional control and pathogenicity. J Virol 72, 8124–8132.
    [Google Scholar]
  18. van Els, C. A. C. M. & Nanan, R. ( 2002; ). T cell responses in acute measles. Viral Immunol 15, 435–450.[CrossRef]
    [Google Scholar]
  19. Weidinger, G. ( 2002; ). Measles virus-specific T cell immunity in rodent models. Viral Immunol 15, 429–434.[CrossRef]
    [Google Scholar]
  20. Weidinger, G., Czub, S., Neumeister, C., Harriott, P., ter Meulen, V. & Niewiesk, S. ( 2000; ). Role of CD4+ and CD8+ T cells in the prevention of measles virus induced encephalitis in mice. J Gen Virol 81, 2707–2713.
    [Google Scholar]
  21. Weidinger, G., Henning, G., ter Meulen, V. & Niewiesk, S. ( 2001; ). Inhibition of major histocompatibility complex class II-dependent antigen presentation by neutralization of gamma interferon leads to breakdown of resistance against measles virus-induced encephalitis. J Virol 75, 3059–3065.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.18834-0
Loading
/content/journal/jgv/10.1099/vir.0.18834-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error