RT Journal Article SR Electronic(1) A1 Belz, Gabrielle T. A1 Liu, Haiyan A1 Andreansky, Samita A1 Doherty, Peter C. A1 Stevenson, Philip G.YR 2003 T1 Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-Ab−/− mice JF Journal of General Virology, VO 84 IS 2 SP 337 OP 341 DO https://doi.org/10.1099/vir.0.18821-0 PB Microbiology Society, SN 1465-2099, AB The murine gammaherpesvirus-68 kills I-Ab−/− mice despite the presence of virus-specific CD8+ cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-Ab−/− mice and I-Ab+/+ controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4+ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.18821-0