1887

Abstract

The murine gammaherpesvirus-68 kills I-A mice despite the presence of virus-specific CD8 cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-A mice and I-A controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4 T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.

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2003-02-01
2020-01-27
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