1887

Abstract

The Miyako Islands, located in the southernmost part of Japan, have been reported to be endemic for hepatitis delta virus (HDV). The majority of HDV patients in this area exhibit a relatively mild course of infection that evolves into a quiescent cirrhotic condition. The entire nucleotide sequence of the Miyako isolate (L215) of HDV obtained from a cirrhotic patient infected with HDV was determined. This isolate, L215, comprises 1682 nt and encodes 213 aa of the hepatitis delta antigen. Phylogenetic analysis showed that L215 is closely related to the Taiwanese genotype IIb HDV isolate. In addition, the predicted folding structure of the antigenomic RNA substrate was different from those of the published genotype II sequences.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.18762-0
2003-02-01
2020-07-11
Loading full text...

Full text loading...

/deliver/fulltext/jgv/84/2/vir840461.html?itemId=/content/journal/jgv/10.1099/vir.0.18762-0&mimeType=html&fmt=ahah

References

  1. Arakawa Y., Moriyama M., Taira M., Hayashi N., Tanaka N., Okubo H., Sugitani M.. 2000; Molecular analysis of hepatitis D virus infection in Miyako Island, a small Japanese island. J Viral Hepatitis7:375–381
    [Google Scholar]
  2. Bergmann K. F., Gerin J. L.. 1986; Antigens of hepatitis delta virus in the liver and serum of humans and animals. J Infect Dis154:702–706
    [Google Scholar]
  3. Bonino F., Heermann K. H., Rizzetto M., Gerlich W. H.. 1986; Hepatitis delta virus: protein composition of delta antigen and its hepatitis B virus-derived envelope. J Virol58:945–950
    [Google Scholar]
  4. Casey J. L., Bergmann K. F., Brown T. L., Gerin J. L.. 1992; Structural requirements for RNA editing in hepatitis delta virus: evidence for a uridine-to-cytidine editing mechanism. Proc Natl Acad Sci U S A89:7149–7153
    [Google Scholar]
  5. Casey J. L., Brown T. L., Colan E. J., Wingnall F. S., Gerin J. L.. 1993; A genotype of hepatitis D virus that occurs in northern South America. Proc Natl Acad Sci U S A90:9016–9020
    [Google Scholar]
  6. Chomczynski P., Sacchi N.. 1987; Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem162:156–159
    [Google Scholar]
  7. Gerin J. L., Casey J. L., Purcell R. H.. 2001; Hepatitis delta virus. In Fields Virology , 4th edn.vol II pp 3037–3050 Edited by Knipe D. M., Howley P. M.. Philadelphia: Lippincott Williams & Wilkins;
    [Google Scholar]
  8. Hsu S.-C., Syu W.-J., Sheen I.-J., Liu H.-T., Jeng K.-S., Wu J.-C.. 2002; Varied assembly and RNA editing efficiencies between genotype I and II hepatitis D virus and their implications. Hepatology35:665–672
    [Google Scholar]
  9. Imazeki F., Omata M., Ohto M.. 1991; Complete nucleotide sequence of hepatitis delta virus RNA in Japan. Nucleic Acids Res19:5439
    [Google Scholar]
  10. Ivaniushina V., Radjef N., Alexeeva M., Gault E., Semenov S., Salhi M., Kiselev O., Deny P.. 2001; Hepatitis delta virus genotypes I and II cocirculate in an endemic area of Yakutia, Russia. J Gen Virol82:2709–2718
    [Google Scholar]
  11. Lai M. M. C.. 1995; The molecular biology of hepatitis delta virus. Annu Rev Biochem64:259–286
    [Google Scholar]
  12. Lee C.-M., Changchien C.-S., Chung J.-C., Liaw Y.-F.. 1996; Characterization of a new genotype II hepatitis delta virus from Taiwan. J Med Virol49:145–154
    [Google Scholar]
  13. Makino S., Chang M.-F., Shieh C.-K., Kamahora T., Vannier D. M., Govindarajan S., Lai M. M. C.. 1987; Molecular cloning and sequencing of a human hepatitis delta (δ) virus RNA. Nature329:343–346
    [Google Scholar]
  14. Monjardino J.. 1996; Replication of hepatitis delta virus. J Viral Hepat3:163–166
    [Google Scholar]
  15. Nakano T., Shapiro C. N., Hadler S. C., Casey J. L., Mizokami M., Orito E., Robertson B. H.. 2001; Characterization of hepatitis D virus genotype III among Yucpa Indians in Venezuela. J Gen Virol82:2183–2189
    [Google Scholar]
  16. Nakasone H., Sakugawa H., Shokita H.. 8 other authors 1998; Prevalence and clinical features of hepatitis delta virus infection in the Miyako Islands, Okinawa, Japan. J Gastroenterol33:850–854
    [Google Scholar]
  17. Rizzetto M., Canese M. G., Arico S., Crivelli O., Trepo C., Bonino F., Verme G.. 1977; Immunofluorescence detection of new antigen-antibody system (δ/anti-δ) associated to hepatitis B virus in liver and in serum of HBsAg carriers. Gut18:997–1003
    [Google Scholar]
  18. Sakugawa H., Nakasone H., Shokita H., Nakayoshi T., Kinjo F., Saito A., Yamashiro A., Miyagi Y.. 1995; Seroepidemiological study of hepatitis delta virus infection in Okinawa, Japan. J Med Virol45:312–315
    [Google Scholar]
  19. Sakugawa H., Nakasone H., Shokita H.. 10 other authors 1997a; Seroepidemiological study on hepatitis delta virus infection in the Irabu Islands, Okinawa, Japan. J Gastroenterol Hepatol12:299–304
    [Google Scholar]
  20. Sakugawa H., Nakasone H., Kawakami Y.. & 12 other authors (1997b). Determination of hepatitis delta virus (HDV)-RNA in asymptomatic cases of HDV infection. Am J Gastroenterol92:2232–2236
    [Google Scholar]
  21. Sakugawa H., Nakasone H., Nakayoshi T.. 7 other authors 1999; Hepatitis delta virus genotype IIb predominates in an endemic area, Okinawa, Japan. J Med Virol58:366–372
    [Google Scholar]
  22. Saldanha J. A., Thomas H. C., Monjardino J. P.. 1990; Cloning and sequencing of RNA of hepatitis delta virus isolated from human serum. J Gen Virol71:1603–1606
    [Google Scholar]
  23. Wang K.-S., Choo Q.-L., Weiner A. J.. 7 other authors 1986; Structure, sequence and expression of the hepatitis delta (δ) viral genome. Nature323:508–514
    [Google Scholar]
  24. Wang K.-S., Choo Q.-L., Weiner A. J.. 7 other authors 1987; Structure, sequence and expression of the hepatitis delta (δ) virus genome. Nature328:456
    [Google Scholar]
  25. Weiner A. J., Choo Q.-L., Wang K.-S., Govindarajan S., Redeker A. G., Gerin J. L., Houghton M.. 1988; A single antigenomic open reading frame of the hepatitis delta virus encodes the epitope(s) of both hepatitis delta antigen polypeptides p24δ and p27δ. J Virol62:594–599
    [Google Scholar]
  26. Wu J.-C., Chiang T.-Z., Sheen I.-J.. 1998; Characterization and phylogenetic analysis of a novel hepatitis D virus strain discovered by restriction fragment length polymorphism analysis. J Gen Virol79:1105–1113
    [Google Scholar]
  27. Yang A., Papaioannou C., Hadzyannis S., Thomas H., Monjardino J.. 1995; Base changes at positions 1014 and 578 of delta virus RNA in Greek isolates maintain base pair in rod conformation with efficient RNA editing. J Med Virol47:113–119
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.18762-0
Loading
/content/journal/jgv/10.1099/vir.0.18762-0
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error