1887

Abstract

Epstein–Barr virus (EBV) is associated with lymphoma in immunocompromised patients. This study provides evidence that the expression of EBV nuclear antigen-3 genes can be directed from the F promoter in different type I Burkitt's lymphoma cell lines and in some lymphomas from human immunodeficiency virus-infected patients. This expression occurs predominantly after induction of the EBV lytic cycle.

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2003-04-01
2021-03-05
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References

  1. Barletta J. M., Kingma D. W., Ling Y., Charache P., Mann R. B., Ambinder R. F.. 1993; Rapid in situ hybridization for the diagnosis of latent Epstein–Barr virus infection. Mol Cell Probes7:105–109
    [Google Scholar]
  2. Bodescot M., Perricaudet M.. 1986; Epstein–Barr virus mRNAs produced by alternative splicing. Nucleic Acids Res14:7103–7114
    [Google Scholar]
  3. Diebold J., Jaffe E. S., Raphaël M., Warnke R. A.. 2001; Burkitt’s lymphoma in pathology and genetics. In Tumours of Haematopoietic and Lymphoid Tissue pp 181–184 Edited by Jaffe E. S., Harris N. L., Stein H., Vardiman J. W.. Lyon: IARC;
    [Google Scholar]
  4. Fahmi H., Cochet C., Hmama Z., Opolon P., Joab I.. 2000; Transforming growth factor β 1 stimulates expression of the Epstein–Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway. J Virol74:5810–5818
    [Google Scholar]
  5. Gaidano G., Capello D., Carbone A.. 2000; The molecular basis of acquired immunodeficiency syndrome-related lymphomagenesis. Semin Oncol27:431–441
    [Google Scholar]
  6. Hamilton-Dutoit S. J., Raphaël M., Audouin J., Diebold J., Lisse I., Pedersen C., Oksenhendler E., Marelle L., Pallesen G.. 1993; In situ demonstration of Epstein–Barr virus small RNAs (EBER-1) in acquired immunodeficiency syndrome-related lymphomas: correlation with tumor morphology and primary site. Blood82:619–624
    [Google Scholar]
  7. Harris N. L., Jaffe E. S., Stein H.. 7 other authors 1994; A revised European–American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood84:1361–1392
    [Google Scholar]
  8. Hudson G. S., Farrell P. J., Barrell B. G.. 1985; Two related but differentially expressed potential membrane proteins encoded by the Eco RI Dhet region of Epstein–Barr virus B95-8. J Virol53:528–535
    [Google Scholar]
  9. Kelly G., Bell A., Rickinson A.. 2002; Epstein–Barr virus-associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2. Nat Med8:1098–1104
    [Google Scholar]
  10. Kerdiles B., Walls D., Triki H., Perricaudet M., Joab I.. 1990; cDNA cloning and transient expression of the Epstein–Barr virus-determined nuclear antigen EBNA3B in human cells and identification of novel transcripts from its coding region. J Virol64:1812–1816
    [Google Scholar]
  11. Kieff E., Rickinson A. B.. 2001; Epstein–Barr virus and its replication. In Fields Virology , 4th edn. pp 2511–2573 Edited by Fields B. N., Howley P.M.. Philadelphia: Lippincott Williams & Wilkins;
    [Google Scholar]
  12. Lear A. L., Rowe M., Kurilla M. G., Lee S., Henderson S., Kieff E., Rickinson A. B.. 1992; The Epstein–Barr virus (EBV) nuclear antigen 1 Bam HI F promoter is activated on entry of EBV-transformed B cells into the lytic cycle. J Virol66:7461–748
    [Google Scholar]
  13. Martel-Renoir D., Grunewald V., Touitou R., Schwaab G., Joab I.. 1995; Qualitative analysis of the expression of Epstein–Barr virus lytic genes in nasopharyngeal carcinoma biopsies. J Gen Virol76:1401–1408
    [Google Scholar]
  14. Niedobitek G., Agathanggelou A., Rowe M., Jones E. L., Jones D. B., Turyaguma P., Oryema J., Wright D. H., Young L. S.. 1995; Heterogeneous expression of Epstein–Barr virus latent proteins in endemic Burkitt's lymphoma. Blood86:659–665
    [Google Scholar]
  15. Nonkwelo C., Skinner J., Bell A., Rickinson A., Sample J.. 1996; Transcription start sites downstream of the Epstein–Barr virus (EBV) Fp promoter in early-passage Burkitt lymphoma cells define a fourth promoter for expression of the EBV EBNA-1 protein. J Virol70:623–627
    [Google Scholar]
  16. Radkov S. A., Bain M., Farrell P., West M., Rowe M., Allday M.. 1997; Epstein–Barr virus EBNA3C represses Cp, the major promoter for EBNA expression, but has no effect on the promoter of the cell gene CD21. J Virol71:8552–8562
    [Google Scholar]
  17. Raphaël M., Borisch B., Jaffe E. S.. 2001; Lymphomas associated with infection by the human immunodeficiency virus (HIV). In Tumours of Haematopoietic and Lymphoid Tissues pp 260–263 Edited by Jaffee E. S., Harris N. L., Stein H., Vardiman J. W.. Lyon: IARC;
    [Google Scholar]
  18. Rowe M., Young L. S., Cadwallader K., Petti L., Kieff E., Rickinson A. B.. 1989; Distinction between Epstein–Barr virus type A (EBNA 2A) and type B (EBNA 2B) isolates extends to the EBNA 3 family of nuclear proteins. J Virol63:1031–1039
    [Google Scholar]
  19. Rickinson A. B., Moss D. J.. 1997; Human cytotoxic T lymphocyte responses to Epstein–Barr virus infection. Annu Rev Immunol15:405–431
    [Google Scholar]
  20. Sample J., Brooks L., Sample C., Young L., Rowe M., Gregory C., Rickinson A. B., Kieff E.. 1991; Restricted Epstein–Barr virus protein expression in Burkitt lymphoma is due to a different Epstein–Barr nuclear antigen 1 transcriptional initiation site. Proc Natl Acad Sci U S A88:6343–6347
    [Google Scholar]
  21. Speck S. H., Strominger J. L.. 1985; Analysis of the transcript encoding the latent Epstein–Barr virus nuclear antigen I: a potentially polycistronic message generated by long-range splicing of several exons. Proc Natl Acad Sci U S A82:8305–8309
    [Google Scholar]
  22. Tierney R. J., Steven N., Young L. S., Rickinson A. B.. 1994; Epstein–Barr virus latency in blood mononuclear cells: analysis of viral gene transcription during primary infection and in the carrier state. J Virol68:7374–7385
    [Google Scholar]
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