Torque teno virus (TTV) is increasingly considered a universal marker of global immune function. The virus is supposed to replicate in lymphocytes, but poor information is available about fluctuations of viraemia after administration of anti-lymphocyte agents. We studied TTV kinetics in a cohort of 70 kidney±pancreas recipients receiving one of two different anti-T-cell induction immunosuppressants. During the first 30 days after anti-T-cell antibody administration, we report kinetics of TTV viraemia compatible with replication in T lymphocytes, and highly dependent on the potency of the anti-T-cell drug administered.
FocosiD., MaggiF., AlbaniM., MaceraL., RicciV., GragnaniS., Di BeoS., GhimentiM., AntonelliG.other authors2010; Torquetenovirus viremia kinetics after autologous stem cell transplantation are predictable and may serve as a surrogate marker of functional immune reconstitution. J Clin Virol 47:189–192 [View Article][PubMed]
FogliM., TortiC., MalacarneF., FiorentiniS., AlbaniM., IzzoI., GiagulliC., MaggiF., CarosiG., CarusoA.2012; Emergence of exhausted B cells in asymptomatic HIV-1-infected patients naïve for HAART is related to reduced immune surveillance. Clin Dev Immunol doi: 10.1155/2012/829584 [Epub ahead of print] [View Article][PubMed]
MaggiF., FocosiD., AlbaniM., LaniniL., VatteroniM. L., PetriniM., Ceccherini-NelliL., PistelloM., BendinelliM.2010; Role of hematopoietic cells in the maintenance of chronic human torquetenovirus plasma viremia. J Virol 84:6891–6893 [View Article][PubMed]
MariscalL. F., López-AlcorochoJ. M., Rodríguez-IñigoE., Ortiz-MovillaN., de LucasS., BartoloméJ., CarreñoV.2002; TT virus replicates in stimulated but not in nonstimulated peripheral blood mononuclear cells. Virology 301:121–129 [View Article][PubMed]
OkamuraA., YoshiokaM., KubotaM., KikutaH., IshikoH., KobayashiK.1999; Detection of a novel DNA virus (TTV) sequence in peripheral blood mononuclear cells. J Med Virol 58:174–177 [View Article][PubMed]
PopowI., LeitnerJ., Grabmeier-PfistershammerK., MajdicO., ZlabingerG. J., KundiM., SteinbergerP.2013; A comprehensive and quantitative analysis of the major specificities in rabbit antithymocyte globulin preparations. Am J Transplant 13:3103–3113 [View Article][PubMed]
ZhongS., YeoW., TangM. W., LinX. R., MoF., HoW. M., HuiP., JohnsonP. J.2001; Gross elevation of TT virus genome load in the peripheral blood mononuclear cells of cancer patients. Ann N Y Acad Sci 945:84–92 [View Article][PubMed]
ZhongS., YeoW., TangM., LiuC., LinX. R., HoW. M., HuiP., JohnsonP. J.2002; Frequent detection of the replicative form of TT virus DNA in peripheral blood mononuclear cells and bone marrow cells in cancer patients. J Med Virol 66:428–434 [View Article][PubMed]