Short-term kinetics of torque teno virus viraemia after induction immunosuppression confirm T lymphocytes as the main replication-competent cells Free

Abstract

Torque teno virus (TTV) is increasingly considered a universal marker of global immune function. The virus is supposed to replicate in lymphocytes, but poor information is available about fluctuations of viraemia after administration of anti-lymphocyte agents. We studied TTV kinetics in a cohort of 70 kidney±pancreas recipients receiving one of two different anti-T-cell induction immunosuppressants. During the first 30 days after anti-T-cell antibody administration, we report kinetics of TTV viraemia compatible with replication in T lymphocytes, and highly dependent on the potency of the anti-T-cell drug administered.

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/content/journal/jgv/10.1099/vir.0.070094-0
2015-01-01
2024-03-29
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References

  1. Focosi D., Maggi F., Albani M., Macera L., Ricci V., Gragnani S., Di Beo S., Ghimenti M., Antonelli G.other authors 2010; Torquetenovirus viremia kinetics after autologous stem cell transplantation are predictable and may serve as a surrogate marker of functional immune reconstitution. J Clin Virol 47:189–192 [View Article][PubMed]
    [Google Scholar]
  2. Fogli M., Torti C., Malacarne F., Fiorentini S., Albani M., Izzo I., Giagulli C., Maggi F., Carosi G., Caruso A. 2012; Emergence of exhausted B cells in asymptomatic HIV-1-infected patients naïve for HAART is related to reduced immune surveillance. Clin Dev Immunol doi: 10.1155/2012/829584 [Epub ahead of print] [View Article][PubMed]
    [Google Scholar]
  3. Galmès J., Li Y., Rajoharison A., Ren L., Dollet S., Richard N., Vernet G., Javouhey E., Wang J.other authors 2013; Potential implication of new torque teno mini viruses in parapneumonic empyema in children. Eur Respir J 42:470–479 [View Article][PubMed]
    [Google Scholar]
  4. Görzer I., Haloschan M., Jaksch P., Klepetko W., Puchhammer-Stöckl E. 2014; Plasma DNA levels of Torque teno virus and immunosuppression after lung transplantation. J Heart Lung Transplant 33:320–323 [View Article][PubMed]
    [Google Scholar]
  5. Maggi F., Bendinelli M. 2009; Immunobiology of the Torque teno viruses and other anelloviruses. Curr Top Microbiol Immunol 331:65–90[PubMed]
    [Google Scholar]
  6. Maggi F., Fornai C., Zaccaro L., Morrica A., Vatteroni M. L., Isola P., Marchi S., Ricchiuti A., Pistello M., Bendinelli M. 2001; TT virus (TTV) loads associated with different peripheral blood cell types and evidence for TTV replication in activated mononuclear cells. J Med Virol 64:190–194 [View Article][PubMed]
    [Google Scholar]
  7. Maggi F., Ricci V., Bendinelli M., Nelli L. C., Focosi D., Papineschi F., Petrini M., Paumgardhen E., Ghimenti M. 2008; Changes in CD8+57+ T lymphocyte expansions after autologous hematopoietic stem cell transplantation correlate with changes in torquetenovirus viremia. Transplantation 85:1867–1868 [View Article][PubMed]
    [Google Scholar]
  8. Maggi F., Focosi D., Albani M., Lanini L., Vatteroni M. L., Petrini M., Ceccherini-Nelli L., Pistello M., Bendinelli M. 2010; Role of hematopoietic cells in the maintenance of chronic human torquetenovirus plasma viremia. J Virol 84:6891–6893 [View Article][PubMed]
    [Google Scholar]
  9. Maggi F., Pifferi M., Michelucci A., Albani M., Sbranti S., Lanini L., Simi P., Macchia P., Pistello M., Bendinelli M. 2011; Torque teno virus viremia load size in patients with selected congenital defects of innate immunity. Clin Vaccine Immunol 18:692–694 [View Article][PubMed]
    [Google Scholar]
  10. Mariscal L. F., López-Alcorocho J. M., Rodríguez-Iñigo E., Ortiz-Movilla N., de Lucas S., Bartolomé J., Carreño V. 2002; TT virus replicates in stimulated but not in nonstimulated peripheral blood mononuclear cells. Virology 301:121–129 [View Article][PubMed]
    [Google Scholar]
  11. Okamura A., Yoshioka M., Kubota M., Kikuta H., Ishiko H., Kobayashi K. 1999; Detection of a novel DNA virus (TTV) sequence in peripheral blood mononuclear cells. J Med Virol 58:174–177 [View Article][PubMed]
    [Google Scholar]
  12. Popow I., Leitner J., Grabmeier-Pfistershammer K., Majdic O., Zlabinger G. J., Kundi M., Steinberger P. 2013; A comprehensive and quantitative analysis of the major specificities in rabbit antithymocyte globulin preparations. Am J Transplant 13:3103–3113 [View Article][PubMed]
    [Google Scholar]
  13. Zhong S., Yeo W., Tang M. W., Lin X. R., Mo F., Ho W. M., Hui P., Johnson P. J. 2001; Gross elevation of TT virus genome load in the peripheral blood mononuclear cells of cancer patients. Ann N Y Acad Sci 945:84–92 [View Article][PubMed]
    [Google Scholar]
  14. Zhong S., Yeo W., Tang M., Liu C., Lin X. R., Ho W. M., Hui P., Johnson P. J. 2002; Frequent detection of the replicative form of TT virus DNA in peripheral blood mononuclear cells and bone marrow cells in cancer patients. J Med Virol 66:428–434 [View Article][PubMed]
    [Google Scholar]
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