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Volume 95, Issue 12

Novel inhibitors of human immunodeficiency virus type 2 infectivity Free

Abstract

Human immunodeficiency virus type 2 (HIV-2) infects about two million people worldwide. HIV-2 has fewer treatment options than HIV-1, yet may evolve drug resistance more quickly. We have analysed several novel drugs for anti-HIV-2 activity. It was observed that 5-azacytidine, clofarabine, gemcitabine and resveratrol have potent anti-HIV-2 activity. The EC values for 5-azacytidine, clofarabine and resveratrol were found to be significantly lower with HIV-2 than with HIV-1. A time-of-addition assay was used to analyse the ability of these drugs to interfere with HIV-2 replication. Reverse transcription was the likely target for antiretroviral activity. Taken together, several novel drugs have been discovered to have activity against HIV-2. Based upon their known activities, these drugs may elicit enhanced HIV-2 mutagenesis and therefore be useful for inducing HIV-2 lethal mutagenesis. In addition, the data are consistent with HIV-2 reverse transcriptase being more sensitive than HIV-1 reverse transcriptase to dNTP pool alterations.

  • Received:
  • Accepted:
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© 2014 The Authors
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2014-12-01
2024-04-19
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Novel inhibitors of human immunodeficiency virus type 2 infectivity
J. Gen. Virol. 95, 2778 (2014); https://doi.org/10.1099/vir.0.069864-0
/content/journal/jgv/10.1099/vir.0.069864-0
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