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Journal of General Virology header logo Journal of General Virology

Volume 95, Issue 11

Critical role for bone marrow stromal antigen 2 in acute Chikungunya virus infection No Access

Abstract

Bone marrow stromal antigen 2 (BST-2; also known as tetherin or CD317) is an IFN-inducible gene that functions to block the release of a range of nascent enveloped virions from infected host cells. However, the role of BST-2 in viral pathogenesis remains poorly understood. BST-2 plays a multifaceted role in innate immunity, as it hinders retroviral infection and possibly promotes infection with some rhabdo- and orthomyxoviruses. This paradoxical role has probably hindered exploration of BST-2 antiviral function . We reported previously that BST-2 tethers Chikungunya virus (CHIKV)-like particles on the cell plasma membrane. To explore the role of BST-2 in CHIKV replication and host protection, we utilized CHIKV strain 181/25 to examine early events during CHIKV infection in a BST-2 mouse model. We observed an interesting dichotomy between WT and BST-2 mice. BST-2 deficiency increased inoculation site viral load, culminating in higher systemic viraemia and increased lymphoid tissues tropism. A suppressed inflammatory innate response demonstrated by impaired expression of IFN-α, IFN-γ and CD40 ligand was observed in BST-2 mice compared with the WT controls. These findings suggested that, in part, BST-2 protects lymphoid tissues from CHIKV infection and regulates CHIKV-induced inflammatory response by the host.

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© 2014 The Authors
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2014-11-01
2026-01-24

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Critical role for bone marrow stromal antigen 2 in acute Chikungunya virus infection
J. Gen. Virol. 95, 2450 (2014); https://doi.org/10.1099/vir.0.068643-0
/content/journal/jgv/10.1099/vir.0.068643-0
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