1887

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Volume 95, Issue 6

Genetic characterization of a novel duck-origin picornavirus with six 2A proteins Free

Abstract

A novel virus was detected from diseased ducks and completely determined. The virus was shown to have a picornavirus-like genome layout. Interestingly, the genome contained a total of up to six 2As, including four 2As (2A1–2A4) each having an NPGP motif, an AIG1-like 2A5, and a parechovirus-like 2A6. The 5′UTR was predicted to possess a hepacivirus/pestivirus-like internal ribosome entry site (IRES). However, the subdomain IIIe consisted of a 3 nt stem and five unpaired bases, distinct from those found in all other HP-like IRESs. The virus was most closely related to duck hepatitis A virus, with amino acid identities of 37.7 %, 39 % and 43.7 % in the P1, P2 and P3 regions, respectively. Based on these investigations, together with phylogenetic analyses, the virus could be considered as the founding member of a novel picornavirus genus that we tentatively named ‘Aalivirus’, with ‘Aalivirus A’ as the type species.

  • Received:
  • Accepted:
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© Microbiology Society
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2014-06-01
2024-04-20
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Genetic characterization of a novel duck-origin picornavirus with six 2A proteins
J. Gen. Virol. 95, 1289 (2014); https://doi.org/10.1099/vir.0.063313-0
/content/journal/jgv/10.1099/vir.0.063313-0
/content/journal/jgv/10.1099/vir.0.063313-0
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