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Journal of General Virology header logo Journal of General Virology

Volume 95, Issue 1

Phylogenetic analysis of Merkel cell polyomavirus based on full-length and gene sequences derived from neoplastic tumours in Japanese patients No Access

Abstract

Most Merkel cell polyomavirus (MCPyV) gene sequences have been reported from Western countries and few data are available for the virus sequences from other geographical areas, especially Asia. Thus, we performed phylogenetic analyses based on the nucleotide sequences of the full-length large T-antigen () and viral protein 1 () genes derived from a variety of cancers in Japanese patients and compared them with sequences from Caucasians. The and gene-based phylogenetic trees identified two main genetic clades. One clade comprised strains isolated from Caucasians, whereas all of the Japanese tumour-derived MCPyV strains belonged to another clade. These findings confirm that most of the MCPyV strains present in Japan form a clade, distinct from Caucasian strains.

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© 2014 SGM
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/content/journal/jgv/10.1099/vir.0.058149-0
2014-01-01
2025-04-25
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/content/journal/jgv/10.1099/vir.0.058149-0
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Phylogenetic analysis of Merkel cell polyomavirus based on full-length LT and VP1 gene sequences derived from neoplastic tumours in Japanese patients
J. Gen. Virol. 95, 135 (2014); https://doi.org/10.1099/vir.0.058149-0
/content/journal/jgv/10.1099/vir.0.058149-0
/content/journal/jgv/10.1099/vir.0.058149-0
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