1887

Journal of General Virology header logo

Volume 95, Issue 1

Phylogenetic analysis of Merkel cell polyomavirus based on full-length and gene sequences derived from neoplastic tumours in Japanese patients Free

Abstract

Most Merkel cell polyomavirus (MCPyV) gene sequences have been reported from Western countries and few data are available for the virus sequences from other geographical areas, especially Asia. Thus, we performed phylogenetic analyses based on the nucleotide sequences of the full-length large T-antigen () and viral protein 1 () genes derived from a variety of cancers in Japanese patients and compared them with sequences from Caucasians. The and gene-based phylogenetic trees identified two main genetic clades. One clade comprised strains isolated from Caucasians, whereas all of the Japanese tumour-derived MCPyV strains belonged to another clade. These findings confirm that most of the MCPyV strains present in Japan form a clade, distinct from Caucasian strains.

  • Received:
  • Accepted:
  • Published Online:
© 2014 SGM
Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.058149-0
2014-01-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/95/1/135.html?itemId=/content/journal/jgv/10.1099/vir.0.058149-0&mimeType=html&fmt=ahah

References

  1. Abascal F., Zardoya R., Posada D. 2005; ProtTest: selection of best-fit models of protein evolution. Bioinformatics 21:2104–2105 [View Article][PubMed]
     [Google Scholar]
  2. Albores-Saavedra J., Batich K., Chable-Montero F., Sagy N., Schwartz A. M., Henson D. E. 2010; Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J Cutan Pathol 37:20–27 [View Article][PubMed]
     [Google Scholar]
  3. Becker J. C., Houben R., Ugurel S., Trefzer U., Pföhler C., Schrama D. 2009; MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J Invest Dermatol 129:248–250 [View Article][PubMed]
     [Google Scholar]
  4. Chun S. M., Yun S. J., Lee S. C., Won Y. H., Lee J. B. 2013; Merkel cell polyomavirus is frequently detected in Korean patients with Merkel cell carcinoma. Ann Dermatol 25:203–207 [View Article][PubMed]
     [Google Scholar]
  5. Dalianis T., Hirsch H. H. 2013; Human polyomaviruses in disease and cancer. Virology 437:63–72 [View Article][PubMed]
     [Google Scholar]
  6. Feng H., Shuda M., Chang Y., Moore P. S. 2008; Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319:1096–1100 [View Article][PubMed]
     [Google Scholar]
  7. Foulongne V., Kluger N., Dereure O., Brieu N., Guillot B., Segondy M. 2008; Merkel cell polyomavirus and Merkel cell carcinoma, France. Emerg Infect Dis 14:1491–1493 [View Article][PubMed]
     [Google Scholar]
  8. Garneski K. M., Warcola A. H., Feng Q., Kiviat N. B., Leonard J. H., Nghiem P. 2009; Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J Invest Dermatol 129:246–248 [View Article][PubMed]
     [Google Scholar]
  9. Guindon S., Dufayard J. F., Lefort V., Anisimova M., Hordijk W., Gascuel O. 2010; New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0. Syst Biol 59:307–321 [View Article][PubMed]
     [Google Scholar]
  10. Hashida Y., Imajoh M., Nemoto Y., Kamioka M., Taniguchi A., Taguchi T., Kume M., Orihashi K., Daibata M. 2013a; Detection of Merkel cell polyomavirus with a tumour-specific signature in non-small cell lung cancer. Br J Cancer 108:629–637 [View Article][PubMed]
     [Google Scholar]
  11. Hashida Y., Imajoh M., Daibata M. 2013b; Gene expression analysis in Merkel cell polyomavirus-positive non-small cell lung cancer from Japanese patients. Int J Cancer 133:3014–3015 [View Article][PubMed]
     [Google Scholar]
  12. Hattori T., Takeuchi Y., Takenouchi T., Hirofuji A., Tsuchida T., Kabumoto T., Fujiwara H., Ito M., Shimizu A. other authors 2013; The prevalence of Merkel cell polyomavirus in Japanese patients with Merkel cell carcinoma. J Dermatol Sci 70:99–107 [View Article][PubMed]
     [Google Scholar]
  13. Imajoh M., Hashida Y., Nemoto Y., Oguri H., Maeda N., Furihata M., Fukaya T., Daibata M. 2012a; Detection of Merkel cell polyomavirus in cervical squamous cell carcinomas and adenocarcinomas from Japanese patients. Virol J 9:154 [View Article][PubMed]
     [Google Scholar]
  14. Imajoh M., Hashida Y., Taniguchi A., Kamioka M., Daibata M. 2012b; Novel human polyomaviruses, Merkel cell polyomavirus and human polyomavirus 9, in Japanese chronic lymphocytic leukemia cases. J Hematol Oncol 5:25 [View Article][PubMed]
     [Google Scholar]
  15. Imajoh M., Hashida Y., Nakajima H., Sano S., Daibata M. 2013; Prevalence and viral DNA loads of three novel human polyomaviruses in skin cancers from Japanese patients. J Dermatol 40:657–660 [View Article][PubMed]
     [Google Scholar]
  16. Kassem A., Schöpflin A., Diaz C., Weyers W., Stickeler E., Werner M., Zur Hausen A. 2008; Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res 68:5009–5013 [View Article][PubMed]
     [Google Scholar]
  17. Katano H., Ito H., Suzuki Y., Nakamura T., Sato Y., Tsuji T., Matsuo K., Nakagawa H., Sata T. 2009; Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi’s sarcoma. J Med Virol 81:1951–1958 [View Article][PubMed]
     [Google Scholar]
  18. Kuwamoto S., Higaki H., Kanai K., Iwasaki T., Sano H., Nagata K., Kato K., Kato M., Murakami I. other authors 2011; Association of Merkel cell polyomavirus infection with morphologic differences in Merkel cell carcinoma. Hum Pathol 42:632–640 [View Article][PubMed]
     [Google Scholar]
  19. Martel-Jantin C., Filippone C., Cassar O., Peter M., Tomasic G., Vielh P., Brière J., Petrella T., Aubriot-Lorton M. H. other authors 2012; Genetic variability and integration of Merkel cell polyomavirus in Merkel cell carcinoma. Virology 426:134–142 [View Article][PubMed]
     [Google Scholar]
  20. Moens U., Ludvigsen M., Van Ghelue M. 2011; Human polyomaviruses in skin diseases. Pathol Res Int 2011:123491[PubMed] [CrossRef]
     [Google Scholar]
  21. Murakami M., Imajoh M., Ikawa T., Nakajima H., Kamioka M., Nemoto Y., Ujihara T., Uchiyama J., Matsuzaki S. other authors 2011; Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma. J Clin Virol 50:37–41 [View Article][PubMed]
     [Google Scholar]
  22. Nakajima H., Takaishi M., Yamamoto M., Kamijima R., Kodama H., Tarutani M., Sano S. 2009; Screening of the specific polyoma virus as diagnostic and prognostic tools for Merkel cell carcinoma. J Dermatol Sci 56:210–212 [View Article][PubMed]
     [Google Scholar]
  23. Pantulu N. D., Pallasch C. P., Kurz A. K., Kassem A., Frenzel L., Sodenkamp S., Kvasnicka H. M., Wendtner C. M., Zur Hausen A. 2010; Detection of a novel truncating Merkel cell polyomavirus large T antigen deletion in chronic lymphocytic leukemia cells. Blood 116:5280–5284 [View Article][PubMed]
     [Google Scholar]
  24. Posada D. 2008; jModelTest: phylogenetic model averaging. Mol Biol Evol 25:1253–1256 [View Article][PubMed]
     [Google Scholar]
  25. Saitou N., Nei M. 1987; The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol 4:406–425[PubMed]
     [Google Scholar]
  26. Schowalter R. M., Pastrana D. V., Pumphrey K. A., Moyer A. L., Buck C. B. 2010; Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin. Cell Host Microbe 7:509–515 [View Article][PubMed]
     [Google Scholar]
  27. Shuda M., Feng H., Kwun H. J., Rosen S. T., Gjoerup O., Moore P. S., Chang Y. 2008; T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus. Proc Natl Acad Sci U S A 105:16272–16277 [View Article][PubMed]
     [Google Scholar]
  28. Spurgeon M. E., Lambert P. F. 2013; Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential. Virology 435:118–130 [View Article][PubMed]
     [Google Scholar]
  29. Thompson J. D., Higgins D. G., Gibson T. J. 1994; clustal w: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673–4680 [View Article][PubMed]
     [Google Scholar]
  30. Wieland U., Kreuter A. 2011; Merkel cell polyomavirus infection and Merkel cell carcinoma in HIV-positive individuals. Curr Opin Oncol 23:488–493 [View Article][PubMed]
     [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.058149-0
Loading
Phylogenetic analysis of Merkel cell polyomavirus based on full-length LT and VP1 gene sequences derived from neoplastic tumours in Japanese patients
J. Gen. Virol. 95, 135 (2014); https://doi.org/10.1099/vir.0.058149-0
/content/journal/jgv/10.1099/vir.0.058149-0
/content/journal/jgv/10.1099/vir.0.058149-0
Loading

Data & Media loading...

Supplements

Supplementary material 1

PDF

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error