1887

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Volume 95, Issue 1

Different functions of the common P/V/W and V-specific domains of rinderpest virus V protein in blocking IFN signalling Open Access

Abstract

The V proteins of paramyxoviruses are composed of two evolutionarily distinct domains, the N-terminal 75 % being common to the viral P, V and W proteins, and not highly conserved between viruses, whilst the remaining 25 % consists of a cysteine-rich V-specific domain, which is conserved across almost all paramyxoviruses. There is evidence supporting a number of different functions of the V proteins of morbilliviruses in blocking the signalling pathways of type I and II IFNs, but it is not clear which domains of V are responsible for which activities and whether all these activities are required for effective blockade of IFN signalling. We have shown here that the two domains of rinderpest virus V protein have distinct functions: the N-terminal domain acted to bind STAT1, whilst the C-terminal V-specific domain interacted with the IFN receptor-associated kinases Jak1 and Tyk2. Effective blockade of IFN signalling required the intact V protein.

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© 2014 SGM
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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2014-01-01
2024-04-25
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Different functions of the common P/V/W and V-specific domains of rinderpest virus V protein in blocking IFN signalling
J. Gen. Virol. 95, 44 (2014); https://doi.org/10.1099/vir.0.056739-0
/content/journal/jgv/10.1099/vir.0.056739-0
/content/journal/jgv/10.1099/vir.0.056739-0
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