1887

Abstract

More than 170 human papillomavirus (HPV) types have been completely sequenced, curated and divided into five genera: , , , and . With the application of PCR methods, hundreds of putative novel HPV types have been identified as PCR amplicons in mucosa and skin. However, at present there are no studies reporting a systematic search of the currently known L1 amplicons and their phylogenetic relationships. This survey revealed the existence of at least 202 different putative HPV types that are pending for full-genome characterization: five alphapapillomaviruses, 37 betapapillomaviruses, 159 gammapapillomaviruses and one mupapillomavirus. All potential viruses of the genera and were grouped in the defined species, while 59 putative gammapapillomaviruses types were segregated in 21 unidentified putative species. These data highlight the need for progress in the identification of additional taxa of the family in order to elucidate the diversity, evolution and medical implications of these viruses.

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2013-11-01
2019-10-18
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References

  1. Antonsson A., Forslund O., Ekberg H., Sterner G., Hansson B. G.. ( 2000;). The ubiquity and impressive genomic diversity of human skin papillomaviruses suggest a commensalic nature of these viruses. . J Virol 74:, 11636–11641. [CrossRef][PubMed]
    [Google Scholar]
  2. Asgari M. M., Kiviat N. B., Critchlow C. W., Stern J. E., Argenyi Z. B., Raugi G. J., Berg D., Odland P. B., Hawes S. E., de Villiers E. M.. ( 2008;). Detection of human papillomavirus DNA in cutaneous squamous cell carcinoma among immunocompetent individuals. . J Invest Dermatol 128:, 1409–1417. [CrossRef][PubMed]
    [Google Scholar]
  3. Berkhout R. J., Bouwes Bavinck J. N., ter Schegget J.. ( 2000;). Persistence of human papillomavirus DNA in benign and (pre)malignant skin lesions from renal transplant recipients. . J Clin Microbiol 38:, 2087–2096.[PubMed]
    [Google Scholar]
  4. Bernard H. U., Burk R. D., Chen Z., van Doorslaer K., zur Hausen H., de Villiers E. M.. ( 2010;). Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. . Virology 401:, 70–79. [CrossRef][PubMed]
    [Google Scholar]
  5. Bottalico D., Chen Z., Dunne A., Ostoloza J., McKinney S., Sun C., Schlecht N. F., Fatahzadeh M., Herrero R.. & other authors ( 2011;). The oral cavity contains abundant known and novel human papillomaviruses from the Betapapillomavirus and Gammapapillomavirus genera. . J Infect Dis 204:, 787–792. [CrossRef][PubMed]
    [Google Scholar]
  6. Chen A. C., McMillan N. A., Antonsson A.. ( 2008;). Human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure. . J Gen Virol 89:, 2891–2897. [CrossRef][PubMed]
    [Google Scholar]
  7. Chouhy D., Gorosito M., Sánchez A., Serra E. C., Bergero A., Fernandez Bussy R., Giri A. A.. ( 2010;). New generic primer system targeting mucosal/genital and cutaneous human papillomaviruses leads to the characterization of HPV 115, a novel Beta-papillomavirus species 3. . Virology 397:, 205–216. [CrossRef][PubMed]
    [Google Scholar]
  8. Chouhy D., Bolatti E. M., Piccirilli G., Sánchez A., Fernandez Bussy R., Giri A. A.. ( 2013;). Identification of human papillomavirus type 156, the prototype of a new human gammapapillomavirus species, by a generic and highly sensitive PCR strategy for long DNA fragments. . J Gen Virol 94:, 524–533. [CrossRef][PubMed]
    [Google Scholar]
  9. de Villiers E. M.. ( 2013;). Cross-roads in the classification of papillomaviruses. . Virology [Epub ahead of print] [CrossRef][PubMed]
    [Google Scholar]
  10. de Villiers E. M., Fauquet C., Broker T. R., Bernard H. U., zur Hausen H.. ( 2004;). Classification of papillomaviruses. . Virology 324:, 17–27. [CrossRef][PubMed]
    [Google Scholar]
  11. Drummond A. J., Suchard M. A., Xie D., Rambaut A.. ( 2012;). Bayesian phylogenetics with beauti and the beast 1.7. . Mol Biol Evol 29:, 1969–1973. [CrossRef][PubMed]
    [Google Scholar]
  12. Forslund O.. ( 2007;). Genetic diversity of cutaneous human papillomaviruses. . J Gen Virol 88:, 2662–2669. [CrossRef][PubMed]
    [Google Scholar]
  13. Forslund O., Antonsson A., Nordin P., Stenquist B., Hansson B. G.. ( 1999;). A broad range of human papillomavirus types detected with a general PCR method suitable for analysis of cutaneous tumours and normal skin. . J Gen Virol 80:, 2437–2443.[PubMed]
    [Google Scholar]
  14. Forslund O., Ly H., Higgins G.. ( 2003;). Improved detection of cutaneous human papillomavirus DNA by single tube nested ‘hanging droplet’ PCR. . J Virol Methods 110:, 129–136. [CrossRef][PubMed]
    [Google Scholar]
  15. Forslund O., Iftner T., Andersson K., Lindelof B., Hradil E., Nordin P., Stenquist B., Kirnbauer R., Dillner J., de Villiers E. M..Viraskin Study Group ( 2007;). Cutaneous human papillomaviruses found in sun-exposed skin: Beta-papillomavirus species 2 predominates in squamous cell carcinoma. . J Infect Dis 196:, 876–883. [CrossRef][PubMed]
    [Google Scholar]
  16. Gottschling M., Göker M., Stamatakis A., Bininda-Emonds O. R., Nindl I., Bravo I. G.. ( 2011;). Quantifying the phylodynamic forces driving papillomavirus evolution. . Mol Biol Evol 28:, 2101–2113. [CrossRef][PubMed]
    [Google Scholar]
  17. Harwood C. A., Surentheran T., McGregor J. M., Spink P. J., Leigh I. M., Breuer J., Proby C. M.. ( 2000;). Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals. . J Med Virol 61:, 289–297. [CrossRef][PubMed]
    [Google Scholar]
  18. Harwood C. A., Surentheran T., Sasieni P., Proby C. M., Bordea C., Leigh I. M., Wojnarowska F., Breuer J., McGregor J. M.. ( 2004;). Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin. . Br J Dermatol 150:, 949–957. [CrossRef][PubMed]
    [Google Scholar]
  19. Hazard K., Andersson K., Dillner J., Forslund O.. ( 2007a;). Human papillomavirus subtypes are not uncommon. . Virology 362:, 6–9. [CrossRef][PubMed]
    [Google Scholar]
  20. Hazard K., Karlsson A., Andersson K., Ekberg H., Dillner J., Forslund O.. ( 2007b;). Cutaneous human papillomaviruses persist on healthy skin. . J Invest Dermatol 127:, 116–119. [CrossRef][PubMed]
    [Google Scholar]
  21. Hedtke S. M., Townsend T. M., Hillis D. M.. ( 2006;). Resolution of phylogenetic conflict in large data sets by increased taxon sampling. . Syst Biol 55:, 522–529. [CrossRef][PubMed]
    [Google Scholar]
  22. Kocjan B. J., Jelen M. M., Maver P. J., Seme K., Poljak M.. ( 2011;). Pre-vaccination genomic diversity of human papillomavirus genotype 6 (HPV 6): a comparative analysis of 21 full-length genome sequences. . Infect Genet Evol 11:, 1805–1810. [CrossRef][PubMed]
    [Google Scholar]
  23. Manos M. M., Ting Y., Wright D. K., Lewis A. J., Broker T. R., Wolinski S. M.. ( 1989;). Use of polymerase chain reaction amplification for the detection of genital human papillomaviruses. . Cancer Cells 7:, 209–214.
    [Google Scholar]
  24. Menzo S., Monachetti A., Trozzi C., Ciavattini A., Carloni G., Varaldo P. E., Clementi M.. ( 2001;). Identification of six putative novel human papillomaviruses (HPV) and characterization of candidate HPV type 87. . J Virol 75:, 11913–11919. [CrossRef][PubMed]
    [Google Scholar]
  25. Narechania A., Chen Z., DeSalle R., Burk R. D.. ( 2005;). Phylogenetic incongruence among oncogenic genital alpha human papillomaviruses. . J Virol 79:, 15503–15510. [CrossRef][PubMed]
    [Google Scholar]
  26. Peyton C. L., Wheeler C. M.. ( 1994;). Identification of five novel human papillomavirus sequences in the New Mexico triethnic population. . J Infect Dis 170:, 1089–1092. [CrossRef][PubMed]
    [Google Scholar]
  27. Pfister H., Fuchs P. G., Majewski S., Jablonska S., Pniewska I., Malejczyk M.. ( 2003;). High prevalence of epidermodysplasia verruciformis-associated human papillomavirus DNA in actinic keratoses of the immunocompetent population. . Arch Dermatol Res 295:, 273–279. [CrossRef][PubMed]
    [Google Scholar]
  28. Shamanin V., Glover M., Rausch C., Proby C., Leigh I. M., zur Hausen H., de Villiers E. M.. ( 1994;). Specific types of human papillomavirus found in benign proliferations and carcinomas of the skin in immunosuppressed patients. . Cancer Res 54:, 4610–4613.[PubMed]
    [Google Scholar]
  29. Shamanin V., zur Hausen H., Lavergne D., Proby C. M., Leigh I. M., Neumann C., Hamm H., Goos M., Haustein U. F.. & other authors ( 1996;). Human papillomavirus infections in nonmelanoma skin cancers from renal transplant recipients and nonimmunosuppressed patients. . J Natl Cancer Inst 88:, 802–811. [CrossRef][PubMed]
    [Google Scholar]
  30. Tamura K., Peterson D., Peterson N., Stecher G., Nei M., Kumar S.. ( 2011;). mega5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. . Mol Biol Evol 28:, 2731–2739. [CrossRef][PubMed]
    [Google Scholar]
  31. Varsani A., van der Walt E., Heath L., Rybicki E. P., Williamson A. L., Martin D. P.. ( 2006;). Evidence of ancient papillomavirus recombination. . J Gen Virol 87:, 2527–2531. [CrossRef][PubMed]
    [Google Scholar]
  32. Zwickl D. J., Hillis D. M.. ( 2002;). Increased taxon sampling greatly reduces phylogenetic error. . Syst Biol 51:, 588–598. [CrossRef][PubMed]
    [Google Scholar]
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