1887

Abstract

Hepatitis B virus (HBV) DNA recombinants contribute to ~30 % of the overall full-length sequences already deposited in GenBank. However, their biological behaviour has not been analysed so far. In this study, the replication kinetics of the first D/A recombinant from the American continent differed from its parental genotypes, exhibiting higher extracellular levels of HBV DNA and hepatitis B e antigen. Southern blots of intracellular core-associated HBV DNA were in agreement with such results. Because this recombinant was obtained from an Argentinian injecting drug user belonging to a vulnerable community, these results are of singular relevance for regional public health. Further studies are urgently needed to determine the pathogenicity of these replicative competent clones.

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2013-12-01
2020-04-04
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