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Volume 94, Issue 12

An immunodominant HLA-A*1101-restricted CD8 T-cell response targeting hepatitis B surface antigen in chronic hepatitis B patients Free

Abstract

Hepatitis B virus (HBV) infection is a worldwide public health problem. HBV-specific CD8 CTLs are vital for viral clearance. Identification of immunodominant CTL epitopes from HBV-associated antigens is necessary for therapeutic vaccine development. We showed that the HLA-A*1101 allele is one of the most common alleles in both healthy individuals and chronic hepatitis B (CHB) patients in the Chongqing area, China. However, less than 10 % of epitopes of HBV-associated antigens have been identified in an HLA-A*1101 context. Here, we describe an immunodominant CD8 T-cell response targeting a hepatitis B surface antigen determinant (HBs) restricted by HLA-A*1101 in both healthy individuals and CHB patients. Moreover, HBs is more immunogenic for CTL induction than a known naturally HLA-A*1101-processed epitope from hepatitis B core antigen (HBc). Therefore, the newly identified epitope, HBs, will benefit the development of immunotherapeutic approaches for HBV infection.

  • Received:
  • Accepted:
  • Published Online:
© 2013 SGM
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2013-12-01
2024-04-25
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An immunodominant HLA-A*1101-restricted CD8+ T-cell response targeting hepatitis B surface antigen in chronic hepatitis B patients
J. Gen. Virol. 94, 2717 (2013); https://doi.org/10.1099/vir.0.052167-0
/content/journal/jgv/10.1099/vir.0.052167-0
/content/journal/jgv/10.1099/vir.0.052167-0
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