1887

Abstract

Hepatitis B virus (HBV) infection is a worldwide public health problem. HBV-specific CD8 CTLs are vital for viral clearance. Identification of immunodominant CTL epitopes from HBV-associated antigens is necessary for therapeutic vaccine development. We showed that the HLA-A*1101 allele is one of the most common alleles in both healthy individuals and chronic hepatitis B (CHB) patients in the Chongqing area, China. However, less than 10 % of epitopes of HBV-associated antigens have been identified in an HLA-A*1101 context. Here, we describe an immunodominant CD8 T-cell response targeting a hepatitis B surface antigen determinant (HBs) restricted by HLA-A*1101 in both healthy individuals and CHB patients. Moreover, HBs is more immunogenic for CTL induction than a known naturally HLA-A*1101-processed epitope from hepatitis B core antigen (HBc). Therefore, the newly identified epitope, HBs, will benefit the development of immunotherapeutic approaches for HBV infection.

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2013-12-01
2020-09-22
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