Overexpression of chimaeric murine/ovine PrP (AHQ) in transgenic mice facilitates transmission and differentiation of ruminant prions Free

Preview this article:

There is no abstract available.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.051581-0
2013-11-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/94/11/2577.html?itemId=/content/journal/jgv/10.1099/vir.0.051581-0&mimeType=html&fmt=ahah

References

  1. Andréoletti O., Orge L., Benestad S. L., Béringue V., Litaise C., Simon S., Le Dur A., Laude H., Simmons H.other authors 2011; Atypical/Nor98 scrapie infectivity in sheep peripheral tissues. PLoS Pathog 7:e1001285 [View Article][PubMed]
    [Google Scholar]
  2. Arsac J.-N., Andréoletti O., Bilheude J. M., Lacroux C., Benestad S. L., Baron T. 2007; Similar biochemical signatures and prion protein genotypes in atypical scrapie and Nor98 cases, France and Norway. Emerg Infect Dis 13:58–65 [View Article][PubMed]
    [Google Scholar]
  3. Arsac J.-N., Bétemps D., Morignat E., Féraudet C., Bencsik A., Aubert D., Grassi J., Baron T. 2009; Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype. PLoS ONE 4:e7300 [View Article][PubMed]
    [Google Scholar]
  4. Baylis M., Chihota C., Stevenson E., Goldmann W., Smith A., Sivam K., Tongue S., Gravenor M. B. 2004; Risk of scrapie in British sheep of different prion protein genotype. J Gen Virol 85:2735–2740 [View Article][PubMed]
    [Google Scholar]
  5. Beck K. E., Chaplin M., Stack M., Sallis R. E., Simonini S., Lockey R., Spiropoulos J. 2010; Lesion profiling at primary isolation in RIII mice is insufficient in distinguishing BSE from classical scrapie. Brain Pathol 20:313–322 [View Article][PubMed]
    [Google Scholar]
  6. Beck K. E., Sallis R. E., Lockey R., Vickery C. M., Béringue V., Laude H., Holder T. M., Thorne L., Terry L. A.other authors 2012; Use of murine bioassay to resolve ovine transmissible spongiform encephalopathy cases showing a bovine spongiform encephalopathy molecular profile. Brain Pathol 22:265–279 [View Article][PubMed]
    [Google Scholar]
  7. Benestad S. L., Sarradin P., Thu B., Schönheit J., Tranulis M. A., Bratberg B. 2003; Cases of scrapie with unusual features in Norway and designation of a new type, Nor98. Vet Rec 153:202–208 [View Article][PubMed]
    [Google Scholar]
  8. Benestad S. L., Arsac J.-N., Goldmann W., Nöremark M. 2008; Atypical/Nor98 scrapie: properties of the agent, genetics, and epidemiology. Vet Res 39:19 [View Article][PubMed]
    [Google Scholar]
  9. Billinis C., Psychas V., Leontides L., Spyrou V., Argyroudis S., Vlemmas I., Leontides S., Sklaviadis T., Papadopoulos O. 2004; Prion protein gene polymorphisms in healthy and scrapie-affected sheep in Greece. J Gen Virol 85:547–554 [View Article][PubMed]
    [Google Scholar]
  10. Bruce M., Chree A., McConnell I., Foster J., Pearson G., Fraser H. 1994; Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier. Philos Trans R Soc Lond B Biol Sci 343:405–411 [View Article][PubMed]
    [Google Scholar]
  11. Bruce M. E., Will R. G., Ironside J. W., McConnell I., Drummond D., Suttie A., McCardle L., Chree A., Hope J.other authors 1997; Transmissions to mice indicate that ‘new variant’ CJD is caused by the BSE agent. Nature 389:498–501 [View Article][PubMed]
    [Google Scholar]
  12. Bruce M. E., Boyle A., Cousens S., McConnell I., Foster J., Goldmann W., Fraser H. 2002; Strain characterization of natural sheep scrapie and comparison with BSE. J Gen Virol 83:695–704[PubMed]
    [Google Scholar]
  13. Büeler H., Fischer M., Lang Y., Bluethmann H., Lipp H. P., DeArmond S. J., Prusiner S. B., Aguet M., Weissmann C. 1992; Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature 356:577–582 [View Article][PubMed]
    [Google Scholar]
  14. Buschmann A., Pfaff E., Reifenberg K., Müller H. M., Groschup M. H. 2000; Detection of cattle-derived BSE prions using transgenic mice overexpressing bovine PrPC. Arch Virol Suppl 16:75–86[PubMed]
    [Google Scholar]
  15. Collinge J., Sidle K. C. L., Meads J., Ironside J., Hill A. F. 1996; Molecular analysis of prion strain variation and the aetiology of ‘new variant’ CJD. Nature 383:685–690 [View Article][PubMed]
    [Google Scholar]
  16. Colussi S., Vaccari G., Maurella C., Bona C., Lorenzetti R., Troiano P., Casalinuovo F., Di Sarno A., Maniaci M. G.other authors 2008; Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats. J Gen Virol 89:3173–3176 [View Article][PubMed]
    [Google Scholar]
  17. Crozet C., Flamant F., Bencsik A., Aubert D., Samarut J., Baron T. 2001; Efficient transmission of two different sheep scrapie isolates in transgenic mice expressing the ovine PrP gene. J Virol 75:5328–5334 [View Article][PubMed]
    [Google Scholar]
  18. Dawson M., Hoinville L. J., Hosie B. D., Hunter N.Scrapie Information Group 1998; Guidance on the use of PrP genotyping as an aid to the control of clinical scrapie. Vet Rec 142:623–625[PubMed]
    [Google Scholar]
  19. Díaz C., Vitezica Z. G., Rupp R., Andréoletti O., Elsen J. M. 2005; Polygenic variation and transmission factors involved in the resistance/susceptibility to scrapie in a Romanov flock. J Gen Virol 86:849–857 [View Article][PubMed]
    [Google Scholar]
  20. Fischer M., Rülicke T., Raeber A., Sailer A., Moser M., Oesch B., Brandner S., Aguzzi A., Weissmann C. 1996; Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J 15:1255–1264[PubMed]
    [Google Scholar]
  21. Foster J. D., Parnham D., Chong A., Goldmann W., Hunter N. 2001; Clinical signs, histopathology and genetics of experimental transmission of BSE and natural scrapie to sheep and goats. Vet Rec 148:165–171 [View Article][PubMed]
    [Google Scholar]
  22. Goldmann W., Hunter N., Foster J. D., Salbaum J. M., Beyreuther K., Hope J. 1990; Two alleles of a neural protein gene linked to scrapie in sheep. Proc Natl Acad Sci U S A 87:2476–2480 [View Article][PubMed]
    [Google Scholar]
  23. Goldmann W., Baylis M., Chihota C., Stevenson E., Hunter N. 2005; Frequencies of PrP gene haplotypes in British sheep flocks and the implications for breeding programmes. J Appl Microbiol 98:1294–1302 [View Article][PubMed]
    [Google Scholar]
  24. Götte D. R., Benestad S. L., Laude H., Zurbriggen A., Oevermann A., Seuberlich T. 2011; Atypical scrapie isolates involve a uniform prion species with a complex molecular signature. PLoS ONE 6:e27510 [View Article][PubMed]
    [Google Scholar]
  25. Green R., Horrocks C., Wilkinson A., Hawkins S. A., Ryder S. J. 2005; Primary isolation of the bovine spongiform encephalopathy agent in mice: agent definition based on a review of 150 transmissions. J Comp Pathol 132:117–131 [View Article][PubMed]
    [Google Scholar]
  26. Gretzschel A., Buschmann A., Langeveld J., Groschup M. H. 2006; Immunological characterization of abnormal prion protein from atypical scrapie cases in sheep using a panel of monoclonal antibodies. J Gen Virol 87:3715–3722 [View Article][PubMed]
    [Google Scholar]
  27. Griffiths P. C., Spiropoulos J., Lockey R., Tout A. C., Jayasena D., Plater J. M., Chave A., Green R. B., Simonini S.other authors 2010; Characterization of atypical scrapie cases from Great Britain in transgenic ovine PrP mice. J Gen Virol 91:2132–2138 [View Article][PubMed]
    [Google Scholar]
  28. Groschup M. H., Buschmann A. 2008; Rodent models for prion diseases. Vet Res 39:32 [View Article][PubMed]
    [Google Scholar]
  29. Hunter N., Cairns D., Foster J. D., Smith G., Goldmann W., Donnelly K. 1997; Is scrapie solely a genetic disease?. Nature 386:137 [View Article][PubMed]
    [Google Scholar]
  30. Klingeborn M., Wik L., Simonsson M., Renström L. H. M., Ottinger T., Linné T. 2006; Characterization of proteinase K-resistant N- and C-terminally truncated PrP in Nor98 atypical scrapie. J Gen Virol 87:1751–1760 [View Article][PubMed]
    [Google Scholar]
  31. Kupfer L., Eiden M., Buschmann A., Groschup M. H. 2007; Amino acid sequence and prion strain specific effects on the in vitro and in vivo convertibility of ovine/murine and bovine/murine prion protein chimeras. Biochim Biophys Acta 1772:704–713 [View Article][PubMed]
    [Google Scholar]
  32. Laude H., Vilette D., Le Dur A., Archer F., Soulier S., Besnard N., Essalmani R., Vilotte J.-L. 2002; New in vivo and ex vivo models for the experimental study of sheep scrapie: development and perspectives. C R Biol 325:49–57 [View Article][PubMed]
    [Google Scholar]
  33. Le Dur A., Béringue V., Andréoletti O., Reine F., Laï T. L., Baron T., Bratberg B., Vilotte J.-L., Sarradin P.other authors 2005; A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes. Proc Natl Acad Sci U S A 102:16031–16036 [View Article][PubMed]
    [Google Scholar]
  34. Lühken G., Buschmann A., Brandt H., Eiden M., Groschup M. H., Erhardt G. 2007; Epidemiological and genetical differences between classical and atypical scrapie cases. Vet Res 38:65–80 [View Article][PubMed]
    [Google Scholar]
  35. Moum T., Olsaker I., Hopp P., Moldal T., Valheim M., Moum T., Benestad S. L. 2005; Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases. J Gen Virol 86:231–235 [View Article][PubMed]
    [Google Scholar]
  36. Oesch B., Westaway D., Wälchli M., McKinley M. P., Kent S. B. H., Aebersold R., Barry R. A., Tempst P., Teplow D. B.other authors 1985; A cellular gene encodes scrapie PrP 27-30 protein. Cell 40:735–746 [View Article][PubMed]
    [Google Scholar]
  37. Prusiner S. B. 1982; Novel proteinaceous infectious particles cause scrapie. Science 216:136–144 [View Article][PubMed]
    [Google Scholar]
  38. Prusiner S. B. 1989; Scrapie prions. Annu Rev Microbiol 43:345–374 [View Article][PubMed]
    [Google Scholar]
  39. Prusiner S. B. 1991; Molecular biology of prion diseases. Science 252:1515–1522 [View Article][PubMed]
    [Google Scholar]
  40. Prusiner S. B., Scott M. R., Foster D., Pan K.-M., Groth D., Mirenda C., Torchia M., Yang S.-L., Serban D.other authors 1990; Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication. Cell 63:673–686 [View Article][PubMed]
    [Google Scholar]
  41. Ritchie D. L., Boyle A., McConnell I., Head M. W., Ironside J. W., Bruce M. E. 2009; Transmissions of variant Creutzfeldt–Jakob disease from brain and lymphoreticular tissue show uniform and conserved bovine spongiform encephalopathy-related phenotypic properties on primary and secondary passage in wild-type mice. J Gen Virol 90:3075–3082 [View Article][PubMed]
    [Google Scholar]
  42. Saunders G. C., Cawthraw S., Mountjoy S. J., Hope J., Windl O. 2006; PrP genotypes of atypical scrapie cases in Great Britain. J Gen Virol 87:3141–3149 [View Article][PubMed]
    [Google Scholar]
  43. Simmons M. M., Konold T., Simmons H. A., Spencer Y. I., Lockey R., Spiropoulos J., Everitt S., Clifford D. 2007; Experimental transmission of atypical scrapie to sheep. BMC Vet Res 3:20 [View Article][PubMed]
    [Google Scholar]
  44. Thackray A. M., Hopkins L., Spiropoulos J., Bujdoso R. 2008; Molecular and transmission characteristics of primary-passaged ovine scrapie isolates in conventional and ovine PrP transgenic mice. J Virol 82:11197–11207 [View Article][PubMed]
    [Google Scholar]
  45. Thackray A. M., Hopkins L., Lockey R., Spiropoulos J., Bujdoso R. 2011; Emergence of multiple prion strains from single isolates of ovine scrapie. J Gen Virol 92:1482–1491 [View Article][PubMed]
    [Google Scholar]
  46. Thackray A. M., Hopkins L., Lockey R., Spiropoulos J., Bujdoso R. 2012; Propagation of ovine prions from “poor” transmitter scrapie isolates in ovine PrP transgenic mice. Exp Mol Pathol 92:167–174 [View Article][PubMed]
    [Google Scholar]
  47. Tongue S. C., Pfeiffer D. U., Warner R., Elliott H., Del Rio Vilas V. 2006; Estimation of the relative risk of developing clinical scrapie: the role of prion protein (PrP) genotype and selection bias. Vet Rec 158:43–50 [View Article][PubMed]
    [Google Scholar]
  48. Vaccari G., D’Agostino C., Nonno R., Rosone F., Conte M., Di Bari M. A., Chiappini B., Esposito E., De Grossi L.other authors 2007; Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy. J Virol 81:7306–7309 [View Article][PubMed]
    [Google Scholar]
  49. Vilotte J.-L., Soulier S., Essalmani R., Stinnakre M.-G., Vaiman D., Lepourry L., Da Silva J. C., Besnard N., Dawson M.other authors 2001; Markedly increased susceptibility to natural sheep scrapie of transgenic mice expressing ovine PrP. J Virol 75:5977–5984 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.051581-0
Loading
/content/journal/jgv/10.1099/vir.0.051581-0
Loading

Data & Media loading...

Supplements

Supplementary material 1

PDF

Most cited Most Cited RSS feed