1887

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Volume 94, Issue 6

genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1 Free

Abstract

TRIM5α restricts human immunodeficiency virus type 1 (HIV-1) infection in cynomolgus monkey (CM) cells. We previously reported that a allele expressing TRIM5–cyclophilin A fusion protein was frequently found in CMs. Here, we examined the influence of gene variation on the susceptibility of CMs to a monkey-tropic HIV-1 derivative (HIV-1mt) and found that TRIMCyp homozygotes were highly susceptible to HIV-1mt not only but also . These results provide important insights into the inter-individual differences in susceptibility of macaques to HIV-1mt.

  • Received:
  • Accepted:
  • Published Online:
© 2013 SGM
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2013-06-01
2024-04-19
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TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1
J. Gen. Virol. 94, 1318 (2013); https://doi.org/10.1099/vir.0.050252-0
/content/journal/jgv/10.1099/vir.0.050252-0
/content/journal/jgv/10.1099/vir.0.050252-0
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