1887

Abstract

TRIM5α restricts human immunodeficiency virus type 1 (HIV-1) infection in cynomolgus monkey (CM) cells. We previously reported that a allele expressing TRIM5–cyclophilin A fusion protein was frequently found in CMs. Here, we examined the influence of gene variation on the susceptibility of CMs to a monkey-tropic HIV-1 derivative (HIV-1mt) and found that TRIMCyp homozygotes were highly susceptible to HIV-1mt not only but also . These results provide important insights into the inter-individual differences in susceptibility of macaques to HIV-1mt.

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2013-06-01
2020-01-25
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