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Journal of General Virology header logo Journal of General Virology

Volume 94, Issue 3

Human T-cells directed to seasonal influenza A virus cross-react with 2009 pandemic influenza A (H1N1) and swine-origin triple-reassortant H3N2 influenza viruses No Access

Abstract

Virus-specific CD8 T-cells contribute to protective immunity against influenza A virus (IAV) infections. As the majority of these cells are directed to conserved viral proteins, they may afford protection against IAVs of various subtypes. The present study assessed the cross-reactivity of human CD8 T-lymphocytes, induced by infection with seasonal A (H1N1) or A (H3N2) influenza virus, with 2009 pandemic influenza A (H1N1) virus [A(H1N1)pdm09] and swine-origin triple-reassortant A (H3N2) [A(H3N2)v] viruses that are currently causing an increasing number of human cases in the USA. It was demonstrated that CD8 T-cells induced after seasonal IAV infections exerted lytic activity and produced gamma interferon upon restimulation with A(H1N1)pdm09 and A(H3N2)v influenza A viruses. Furthermore, CD8 T-cells directed to A(H1N1)pdm09 virus displayed a high degree of cross-reactivity with A(H3N2)v viruses. It was concluded that cross-reacting T-cells had the potential to afford protective immunity against A(H1N1)pdm09 viruses during the pandemic and offer some degree of protection against infection with A(H3N2)v viruses.

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© 2013 SGM
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2013-03-01
2025-04-24
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/content/journal/jgv/10.1099/vir.0.048652-0
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Human T-cells directed to seasonal influenza A virus cross-react with 2009 pandemic influenza A (H1N1) and swine-origin triple-reassortant H3N2 influenza viruses
J. Gen. Virol. 94, 583 (2013); https://doi.org/10.1099/vir.0.048652-0
/content/journal/jgv/10.1099/vir.0.048652-0
/content/journal/jgv/10.1099/vir.0.048652-0
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