1887

Abstract

Upon antiretroviral therapy (ART) human immunodeficiency virus (HIV)/human T-cell lymphotropic virus type 1 (HTLV-1) co-infected individuals frequently develop neurological disorders through hitherto unknown mechanisms. Here, we show that effective anti-HIV ART increases HTLV-1 proviral load through a polyclonal integration pattern of HTLV-1 in both CD4 and CD8 T-cell subsets that is reminiscent of that typically associated with HTLV-1-related inflammatory conditions. These data indicate that preventing ART-triggered clonal expansion of HTLV-1-infected cells in co-infected individuals deserves investigation.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.048348-0
2013-04-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/94/4/753.html?itemId=/content/journal/jgv/10.1099/vir.0.048348-0&mimeType=html&fmt=ahah

References

  1. Beilke M. A., Japa S., Vinson D. G. 1998; HTLV-I and HTLV-II virus expression increase with HIV-1 coinfection. J Acquir Immune Defic Syndr Hum Retrovirol 17:391–397 [View Article][PubMed]
    [Google Scholar]
  2. Beilke M. A., Japa S., Moeller-Hadi C., Martin-Schild S. 2005; Tropical spastic paraparesis/human T leukemia virus type 1-associated myelopathy in HIV type 1-coinfected patients. Clin Infect Dis 41:e57–e63 [View Article][PubMed]
    [Google Scholar]
  3. Beilke M. A., Traina-Dorge V. L., Sirois M., Bhuiyan A., Murphy E. L., Walls J. M., Fagan R., Winsor E. L., Kissinger P. J. 2007; Relationship between human T lymphotropic virus (HTLV) type 1/2 viral burden and clinical and treatment parameters among patients with HIV type 1 and HTLV-1/2 coinfection. Clin Infect Dis 44:1229–1234 [View Article][PubMed]
    [Google Scholar]
  4. Berger J. R., Raffanti S., Svenningsson A., McCarthy M., Snodgrass S., Resnick L. 1991; The role of HTLV in HIV-1 neurologic disease. Neurology 41:197–202 [View Article][PubMed]
    [Google Scholar]
  5. Cavrois M., Wain-Hobson S., Wattel E. 1995; Stochastic events in the amplification of HTLV-I integration sites by linker-mediated PCR. Res Virol 146:179–184 [View Article][PubMed]
    [Google Scholar]
  6. Cavrois M., Gessain A., Wain-Hobson S., Wattel E. 1996; Proliferation of HTLV-1 infected circulating cells in vivo in all asymptomatic carriers and patients with TSP/HAM. Oncogene 12:2419–2423[PubMed]
    [Google Scholar]
  7. Cavrois M., Leclercq I., Gout O., Gessain A., Wain-Hobson S., Wattel E. 1998; Persistent oligoclonal expansion of human T-cell leukemia virus type 1-infected circulating cells in patients with Tropical spastic paraparesis/HTLV-1 associated myelopathy. Oncogene 17:77–82 [View Article][PubMed]
    [Google Scholar]
  8. Cavrois M., Gessain A., Gout O., Wain-Hobson S., Wattel E. 2000; Common human T cell leukemia virus type 1 (HTLV-1) integration sites in cerebrospinal fluid and blood lymphocytes of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis indicate that HTLV-1 crosses the blood-brain barrier via clonal HTLV-1-infected cells. J Infect Dis 182:1044–1050 [View Article][PubMed]
    [Google Scholar]
  9. Gessain A., Barin F., Vernant J. C., Gout O., Maurs L., Calender A., de Thé G. 1985; Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 326:407–410 [View Article][PubMed]
    [Google Scholar]
  10. Gillet N. A., Malani N., Melamed A., Gormley N., Carter R., Bentley D., Berry C., Bushman F. D., Taylor G. P., Bangham C. R. 2011; The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones. Blood 117:3113–3122 [View Article][PubMed]
    [Google Scholar]
  11. Harrison L. H., Vaz B., Taveira D. M., Quinn T. C., Gibbs C. J., de Souza S. H., McArthur J. C., Schechter M. 1997; Myelopathy among Brazilians coinfected with human T-cell lymphotropic virus type I and HIV. Neurology 48:13–18 [View Article][PubMed]
    [Google Scholar]
  12. Levin M. C., Lee S. M., Morcos Y., Brady J., Stuart J. 2002; Cross-reactivity between immunodominant human T lymphotropic virus type I tax and neurons: implications for molecular mimicry. J Infect Dis 186:1514–1517 [View Article][PubMed]
    [Google Scholar]
  13. Machuca A., Rodés B., Soriano V. 2001; The effect of antiretroviral therapy on HTLV infection. Virus Res 78:93–100 [View Article][PubMed]
    [Google Scholar]
  14. Mortreux F., Leclercq I., Gabet A. S., Leroy A., Westhof E., Gessain A., Wain-Hobson S., Wattel E. 2001; Somatic mutation in human T-cell leukemia virus type 1 provirus and flanking cellular sequences during clonal expansion in vivo. J Natl Cancer Inst 93:367–377 [View Article][PubMed]
    [Google Scholar]
  15. Mortreux F., Gabet A. S., Wattel E. 2003; Molecular and cellular aspects of HTLV-1 associated leukemogenesis in vivo. Leukemia 17:26–38 [View Article][PubMed]
    [Google Scholar]
  16. Murphy E. L., Grant R. M., Kropp J., Oliveira A., Lee T. H., Busch M. P. 2003; Increased human T-lymphotropic virus type II proviral load following highly active retroviral therapy in HIV-coinfected patients. J Acquir Immune Defic Syndr 33:655–656 [View Article][PubMed]
    [Google Scholar]
  17. Sibon D., Gabet A. S., Zandecki M., Pinatel C., Thête J., Delfau-Larue M. H., Rabaaoui S., Gessain A., Gout O.other authors 2006; HTLV-1 propels untransformed CD4 lymphocytes into the cell cycle while protecting CD8 cells from death. J Clin Invest 116:974–983 [View Article][PubMed]
    [Google Scholar]
  18. Silva M. T., Neves E. S., Grinsztejn B., de Melo Espíndola O., Schor D., Araújo A. 2012; Neurological manifestations of coinfection with HIV and human T-lymphotropic virus type 1. AIDS 26:521–523 [View Article][PubMed]
    [Google Scholar]
  19. Zane L., Sibon D., Mortreux F., Wattel E. 2009; Clonal expansion of HTLV-1 infected cells depends on the CD4 versus CD8 phenotype. Front Biosci 14:3935–3941 [View Article][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.048348-0
Loading
/content/journal/jgv/10.1099/vir.0.048348-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error