1887

Abstract

Bovine papillomavirus type 2 (BPV-2) has been shown to infect and play a role in urinary bladder carcinogenesis of buffaloes grazed on pastures with ferns from the Marmara and Black Sea Regions of Turkey. BPV-2 DNA has been found in both neoplastic and non-neoplastic lesions of the urinary bladder. Furthermore, this virus may be a normal inhabitant of the urinary bladder since BPV-2 DNA has also been detected in clinically normal buffaloes. The viral activation by fern immunosuppressant or carcinogen may trigger the urothelial cell transformation. The E5 oncoprotein was solely detected in urothelial tumours and appeared to be co-localized with the overexpressed and phosphorylated platelet derived growth factor (PDGF) β receptor in a double-colour immunofluorescence assay. Our results indicate that the E5–PDGF β receptor interaction also occurs in spontaneous tumours of the bubaline urinary bladder, revealing an additional role of BPV-2 in bladder carcinogenesis of buffaloes.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.047662-0
2013-02-01
2020-01-27
Loading full text...

Full text loading...

/deliver/fulltext/jgv/94/2/403.html?itemId=/content/journal/jgv/10.1099/vir.0.047662-0&mimeType=html&fmt=ahah

References

  1. Alonso-Amelot M. E. , Avendaño M. . ( 2002; ). Human carcinogenesis and bracken fern: a review of the evidence. . Curr Med Chem 9:, 675–686. [CrossRef] [PubMed]
    [Google Scholar]
  2. Bernard H. U. , Burk R. D. , Chen Z. , van Doorslaer K. , Hausen H. , de Villiers E. M. . ( 2010; ). Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. . Virology 401:, 70–79. [CrossRef] [PubMed]
    [Google Scholar]
  3. Borzacchiello G. , Iovane G. , Marcante M. L. , Poggiali F. , Roperto F. , Roperto S. , Venuti A. . ( 2003; ). Presence of bovine papillomavirus type 2 DNA and expression of the viral oncoprotein E5 in naturally occurring urinary bladder tumours in cows. . J Gen Virol 84:, 2921–2926. [CrossRef] [PubMed]
    [Google Scholar]
  4. Borzacchiello G. , Russo V. , Gentile F. , Roperto F. , Venuti A. , Nitsch L. , Campo M. S. , Roperto S. . ( 2006; ). Bovine papillomavirus E5 oncoprotein binds to the activated form of the platelet-derived growth factor β receptor in naturally occurring bovine urinary bladder tumours. . Oncogene 25:, 1251–1260. [CrossRef] [PubMed]
    [Google Scholar]
  5. Borzacchiello G. , Russo V. , Spoleto C. , Roperto S. , Balcos L. , Rizzo C. , Venuti A. , Roperto F. . ( 2007; ). Bovine papillomavirus type-2 DNA and expression of E5 and E7 oncoproteins in vascular tumours of the urinary bladder in cattle. . Cancer Lett 250:, 82–91. [CrossRef] [PubMed]
    [Google Scholar]
  6. Bottalico D. , Chen Z. , Kocjan B. J. , Seme K. , Poljak M. , Burk R. D. . ( 2012; ). Characterization of human papillomavirus type 120: a novel betapapillomavirus with tropism for multiple anatomical niches. . J Gen Virol 93:, 1774–1779. [CrossRef] [PubMed]
    [Google Scholar]
  7. Campo M. S. . ( 2006; ). Bovine papillomavirus: old system, new lessons?. In Papillomavirus Research - from Natural History to Vaccines and Beyond, pp. 373–387. Edited by Campo M. S. . . Norfolk, UK:: Caister Academic Press;.
    [Google Scholar]
  8. Campo M. S. , Jarrett W. F. H. , Barron R. J. , O’Neil B. W. , Smith K. T. . ( 1992; ). Association of bovine papillomavirus type 2 and bracken fern with bladder cancer in cattle. . Cancer Res 52:, 6898–6904.[PubMed]
    [Google Scholar]
  9. de Villiers E. M. , Fauquet C. , Broker T. R. , Bernard H. U. , zur Hausen H. . ( 2004; ). Classification of papillomaviruses. . Virology 324:, 17–27. [CrossRef] [PubMed]
    [Google Scholar]
  10. IARC ( 2007; ). Monographs on the Evaluation of Carcinogenic Risks to Humans. Human Papillomaviruses, vol. 90. Lyon:: IARC Press;.
    [Google Scholar]
  11. Kainzbauer C. , Rushton J. , Tober R. , Scase T. , Nell B. , Sykora S. , Brandt S. . ( 2012; ). Bovine papillomavirus type 1 and Equus caballus papillomavirus 2 in equine squamous cell carcinoma of the head and neck in a Connemara mare. . Equine Vet J 44:, 112–115. [CrossRef] [PubMed]
    [Google Scholar]
  12. Lancaster W. D. , Theilen G. H. , Olson C. . ( 1979; ). Hybridization of bovine papilloma virus type 1 and type 2 DNA to DNA from virus-induced hamster tumors and naturally occurring equine tumors. . Intervirology 11:, 227–233. [CrossRef] [PubMed]
    [Google Scholar]
  13. Lunardi M. , Alfieri A. A. , Otonel R. A. , de Alcântara B. K. , Rodrigues W. B. , de Miranda A. B. , Alfieri A. F. . ( 2012; ). Genetic characterization of a novel bovine papillomavirus member of the Deltapapillomavirus genus. . Vet Microbiol. [CrossRef] [PubMed]
    [Google Scholar]
  14. Moody C. A. , Laimins L. A. . ( 2010; ). Human papillomavirus oncoproteins: pathways to transformation. . Nat Rev Cancer 10:, 550–560. [CrossRef] [PubMed]
    [Google Scholar]
  15. Munday J. S. , Knight C. G. . ( 2010; ). Amplification of feline sarcoid-associated papillomavirus DNA sequences from bovine skin. . Vet Dermatol 21:, 341–344.[PubMed] [CrossRef]
    [Google Scholar]
  16. Orbell G. M. B. , Young S. , Munday J. S. . ( 2011; ). Cutaneous sarcoids in captive African lions associated with feline sarcoid-associated papillomavirus infection. . Vet Pathol 48:, 1176–1179. [CrossRef] [PubMed]
    [Google Scholar]
  17. Ozkul I. A. , Aydin Y. . ( 1996; ). Tumours of the urinary bladder in cattle and water buffalo in the Black Sea region of Turkey. . Br Vet J 152:, 473–475. [CrossRef] [PubMed]
    [Google Scholar]
  18. Pamukcu A. M. . ( 1957; ). Tumors of the urinary bladder in cattle and water buffalo affected with enzootic bovine hematuria. . Zbl Vet Med 4:, 185–197.
    [Google Scholar]
  19. Pamukcu A. M. , Price J. M. , Bryan G. T. . ( 1976; ). Naturally occurring and braken-fern-induced bovine urinary bladder tumors. Clinical and morphological characteristics. . Vet Pathol 13:, 110–122.[PubMed]
    [Google Scholar]
  20. Pangty K. , Singh S. , Goswami R. , Saikumar G. , Somvanshi R. . ( 2010; ). Detection of BPV-1 and -2 and quantification of BPV-1 by real-time PCR in cutaneous warts in cattle and buffaloes. . Transbound Emerg Dis 57:, 185–196. [CrossRef] [PubMed]
    [Google Scholar]
  21. Pathania S. , Dhama K. , Saikumar G. , Shahi S. , Somvanshi R. . ( 2012; ). Detection and quantification of bovine papilloma virus type 2 (BPV-2) by real-time PCR in urine and urinary bladder lesions in enzootic bovine haematuria (EBH)-affected cows. . Transbound Emerg Dis 59:, 79–84. [CrossRef] [PubMed]
    [Google Scholar]
  22. Rector A. , Tachezy R. , Van Ranst M. . ( 2004; ). A sequence-independent strategy for detection and cloning of circular DNA virus genomes by using multiply primed rolling-circle amplification. . J Virol 78:, 4993–4998. [CrossRef] [PubMed]
    [Google Scholar]
  23. Rogovskyy A. S. , Baszler T. V. , Bradway D. S. , Bruning D. L. , Davitt C. M. , Evermann J. F. , Burk R. D. , Chen Z. , Mansfield K. G. , Haldorson G. J. . ( 2012; ). A novel papillomavirus isolated from proliferative skin lesions of a wild American beaver (Castor canadensis). . J Vet Diagn Invest 24:, 750–754. [CrossRef] [PubMed]
    [Google Scholar]
  24. Roperto S. , Brun R. , Paolini F. , Urraro C. , Russo V. , Borzacchiello G. , Pagnini U. , Raso C. , Rizzo C. . & other authors ( 2008; ). Detection of bovine papillomavirus type 2 in the peripheral blood of cattle with urinary bladder tumours: possible biological role. . J Gen Virol 89:, 3027–3033. [CrossRef] [PubMed]
    [Google Scholar]
  25. Roperto S. , Borzacchiello G. , Brun R. , Leonardi L. , Maiolino P. , Martano M. , Paciello O. , Papparella S. , Restucci B. . & other authors ( 2010a; ). A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder. . J Comp Pathol 142:, 95–108. [CrossRef] [PubMed]
    [Google Scholar]
  26. Roperto S. , De Tullio R. , Raso C. , Stifanese R. , Russo V. , Gaspari M. , Borzacchiello G. , Averna M. , Paciello O. . & other authors ( 2010b; ). Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle. . PLoS ONE 5:, e10299. [CrossRef] [PubMed]
    [Google Scholar]
  27. Roperto S. , Comazzi S. , Ciusani E. , Paolini F. , Borzacchiello G. , Esposito I. , Lucà R. , Russo V. , Urraro C. . & other authors ( 2011; ). PBMCs are additional sites of productive infection of bovine papillomavirus type 2. . J Gen Virol 92:, 1787–1794. [CrossRef] [PubMed]
    [Google Scholar]
  28. Roperto S. , Borzacchiello G. , Esposito I. , Riccardi M. , Urraro C. , Lucà R. , Corteggio A. , Tatè R. , Cermola M. . & other authors ( 2012; ). Productive infection of bovine papillomavirus type 2 in the placenta of pregnant cows affected with urinary bladder tumors. . PLoS ONE 7:, e33569. [CrossRef] [PubMed]
    [Google Scholar]
  29. Shafti-Keramat S. , Schellenbacher C. , Handisurya A. , Christensen N. , Reininger B. , Brandt S. , Kirnbauer R. . ( 2009; ). Bovine papillomavirus type 1 (BPV1) and BPV2 are closely related serotypes. . Virology 393:, 1–6. [CrossRef] [PubMed]
    [Google Scholar]
  30. Silvestre O. , Borzacchiello G. , Nava D. , Iovane G. , Russo V. , Vecchio D. , D’Ausilio F. , Gault E. A. , Campo M. S. , Paciello O. . ( 2009; ). Bovine papillomavirus type 1 DNA and E5 oncoprotein expression in water buffalo fibropapillomas. . Vet Pathol 46:, 636–641. [CrossRef] [PubMed]
    [Google Scholar]
  31. Somvanshi R. . ( 2011; ). Papillomatosis in buffaloes: a less-known disease. . Transbound Emerg Dis 58:, 327–332. [CrossRef] [PubMed]
    [Google Scholar]
  32. Somvanshi R. , Pathania S. , Nagarajan N. , Pangty K. , Kumar P. . ( 2012; ). Pathological study of non-neoplastic urinary bladder lesions in cattle and buffaloes: a preliminary report. . Trop Anim Health Prod 44:, 855–861. [CrossRef] [PubMed]
    [Google Scholar]
  33. Suprynowicz F. A. , Baege A. , Sunitha I. , Schlegel R. . ( 2002; ). c-Src activation by the E5 oncoprotein enables transformation independently of PDGF receptor activation. . Oncogene 21:, 1695–1706. [CrossRef] [PubMed]
    [Google Scholar]
  34. van Dyk E. , Bosman A. M. , van Wilpe E. , Williams J. H. , Bengis R. G. , van Heerden J. , Venter E. H. . ( 2012; ). Detection and characterization of papillomavirus in skin lesions of giraffe and sable antelope in South Africa. . J S Afr Vet Assoc 82:, 80–85.
    [Google Scholar]
  35. Vetter J. . ( 2009; ). A biological hazard of our age: bracken fern [Pteridium aquilinum (L.) Kuhn] – a review. . Acta Vet Hung 57:, 183–196. [CrossRef] [PubMed]
    [Google Scholar]
  36. Williams J. H. , van Dyk E. , Nel P. J. , Lane E. , Van Wilpe E. , Bengis R. G. , de Klerk-Lorist L. M. , van Heerden J. . ( 2011; ). Pathology and immunohistochemistry of papillomavirus-associated cutaneous lesions in Cape mountain zebra, giraffe, sable antelope and African buffalo in South Africa. . J S Afr Vet Assoc 82:, 97–106.[PubMed] [CrossRef]
    [Google Scholar]
  37. Wosiaki S. R. , Claus M. P. , Alfieri A. F. , Alfieri A. A. . ( 2006; ). Bovine papillomavirus type 2 detection in the urinary bladder of cattle with chronic enzootic haematuria. . Mem Inst Oswaldo Cruz 101:, 635–638.
    [Google Scholar]
  38. Zhu W. , Dong J. B. , Zhang J. , Uchida K. , Watanabe K. I. , Goto Y. , Haga T. . ( 2012; ). Bos grunniens papillomavirus type 1 (BgPV-1): a novel Deltapapillomavirus associated with fibropapilloma in yak. . J Gen Virol. [CrossRef] [PubMed]
    [Google Scholar]
  39. zur Hausen H. . ( 2009; ). The search for infectious causes of human cancers: where and why. . Virology 392:, 1–10. [CrossRef] [PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.047662-0
Loading
/content/journal/jgv/10.1099/vir.0.047662-0
Loading

Data & Media loading...

Most cited articles

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error