Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism

References

1. Atkins J. F., Wills N. M., Loughran G., Wu C. Y., Parsawar K., Ryan M. D., Wang C. H., Nelson C. C. 2007; A case for “StopGo”: reprogramming translation to augment codon meaning of GGN by promoting unconventional termination (Stop) after addition of glycine and then allowing continued translation (Go). RNA 13:803–810 [View Article][PubMed]
   [Google Scholar]
2. Batson S., Rundell K. 1991; Proteolysis at the 2A/2B junction in Theiler’s murine encephalomyelitis virus. Virology 181:764–767 [View Article][PubMed]
   [Google Scholar]
3. Brown J. D., Ryan M. D. 2010; Ribosome “skipping”: “Stop-Carry On” or “StopGo” translation. In Recoding: Expansion of Decoding Rules Enriches Gene Expression pp. 101–121 Edited by Atkins J. F., Gesteland R. F. Heidelberg: Springer; [View Article]
   [Google Scholar]
4. Donnelly M. L., Gani D., Flint M., Monaghan S., Ryan M. D. 1997; The cleavage activities of aphthovirus and cardiovirus 2A proteins. J Gen Virol 78:13–21[PubMed]
   [Google Scholar]
5. Donnelly M. L., Hughes L. E., Luke G., Mendoza H., ten Dam E., Gani D., Ryan M. D. 2001a; The ‘cleavage’ activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring ‘2A-like’ sequences. J Gen Virol 82:1027–1041[PubMed]
   [Google Scholar]
6. Donnelly M. L., Luke G., Mehrotra A., Li X., Hughes L. E., Gani D., Ryan M. D. 2001b; Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’. J Gen Virol 82:1013–1025[PubMed]
   [Google Scholar]
7. Doronina V. A., Wu C., de Felipe P., Sachs M. S., Ryan M. D., Brown J. D. 2008; Site-specific release of nascent chains from ribosomes at a sense codon. Mol Cell Biol 28:4227–4239 [View Article][PubMed]
   [Google Scholar]
8. Duke G. M., Osorio J. E., Palmenberg A. C. 1990; Attenuation of Mengo virus through genetic engineering of the 5′ noncoding poly(C) tract. Nature 343:474–476 [View Article][PubMed]
   [Google Scholar]
9. Hahn H., Palmenberg A. C. 1996; Mutational analysis of the encephalomyocarditis virus primary cleavage. J Virol 70:6870–6875[PubMed]
   [Google Scholar]
10. Hahn H., Palmenberg A. C. 2001; Deletion mapping of the encephalomyocarditis virus primary cleavage site. J Virol 75:7215–7218 [View Article][PubMed]
    [Google Scholar]
11. Harmon S. A., Updike W., Jia X. Y., Summers D. F., Ehrenfeld E. 1992; Polyprotein processing in cis and in trans by hepatitis A virus 3C protease cloned and expressed in Escherichia coli. J Virol 66:5242–5247[PubMed]
    [Google Scholar]
12. Jackson R. J. 1986; A detailed kinetic analysis of the in vitro synthesis and processing of encephalomyocarditis virus products. Virology 149:114–127 [View Article][PubMed]
    [Google Scholar]
13. Leong L. E.-C., Cornell C. T., Semler B. L. 2002; Processing determinants and functions of cleavage products of picornavirus polyproteins. In Molecular Biology of Picornaviruses pp. 187–197 Edited by Semler B. L., Wimmer E. Washington, D.C.: American Society for Microbiology;
    [Google Scholar]
14. Loughran G., Firth A. E., Atkins J. F. 2011; Ribosomal frameshifting into an overlapping gene in the 2B-encoding region of the cardiovirus genome. Proc Natl Acad Sci U S A 108:E1111–E1119 [View Article][PubMed]
    [Google Scholar]
15. Luke G. A., de Felipe P., Lukashev A., Kallioinen S. E., Bruno E. A., Ryan M. D. 2008; Occurrence, function and evolutionary origins of ‘2A-like’ sequences in virus genomes. J Gen Virol 89:1036–1042 [View Article][PubMed]
    [Google Scholar]
16. Palmenberg A. C. 1990; Proteolytic processing of picornaviral polyprotein. Annu Rev Microbiol 44:603–623 [View Article][PubMed]
    [Google Scholar]
17. Palmenberg A. C., Kirby E. M., Janda M. R., Drake N. L., Duke G. M., Potratz K. F., Collett M. S. 1984; The nucleotide and deduced amino acid sequences of the encephalomyocarditis viral polyprotein coding region. Nucleic Acids Res 12:2969–2985 [View Article][PubMed]
    [Google Scholar]
18. Palmenberg A. C., Parks G. D., Hall D. J., Ingraham R. H., Seng T. W., Pallai P. V. 1992; Proteolytic processing of the cardioviral P2 region: primary 2A/2B cleavage in clone-derived precursors. Virology 190:754–762 [View Article][PubMed]
    [Google Scholar]
19. Parks G. D., Palmenberg A. C. 1987; Site-specific mutations at a picornavirus VP3/VP1 cleavage site disrupt in vitro processing and assembly of capsid precursors. J Virol 61:3680–3687[PubMed]
    [Google Scholar]
20. Rieder E., Bunch T., Brown F., Mason P. W. 1993; Genetically engineered foot-and-mouth disease viruses with poly(C) tracts of two nucleotides are virulent in mice. J Virol 67:5139–5145[PubMed]
    [Google Scholar]
21. Rieder E., Henry T., Duque H., Baxt B. 2005; Analysis of a foot-and-mouth disease virus type A24 isolate containing an SGD receptor recognition site in vitro and its pathogenesis in cattle. J Virol 79:12989–12998 [View Article][PubMed]
    [Google Scholar]
22. Roos R. P., Kong W. P., Semler B. L. 1989; Polyprotein processing of Theiler’s murine encephalomyelitis virus. J Virol 63:5344–5353[PubMed]
    [Google Scholar]
23. Ryan M. D., Drew J. 1994; Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein. EMBO J 13:928–933[PubMed]
    [Google Scholar]
24. Ryan M. D., King A. M., Thomas G. P. 1991; Cleavage of foot-and-mouth disease virus polyprotein is mediated by residues located within a 19 amino acid sequence. J Gen Virol 72:2727–2732 [View Article][PubMed]
    [Google Scholar]
25. Villarreal D., Young C. R., Storts R., Ting J. W., Welsh C. J. 2006; A comparison of the neurotropism of Theiler’s virus and poliovirus in CBA mice. Microb Pathog 41:149–156 [View Article][PubMed]
    [Google Scholar]