RT Journal Article SR Electronic(1) A1 Zhu, Wei A1 Dong, Jian-Bao A1 Zhang, Jun A1 Uchida, Kazuyuki A1 Watanabe, Ken-ichi A1 Goto, Yoshitaka A1 Haga, TakeshiYR 2013 T1 Bos grunniens papillomavirus type 1: a novel deltapapillomavirus associated with fibropapilloma in yak JF Journal of General Virology, VO 94 IS 1 SP 159 OP 165 DO https://doi.org/10.1099/vir.0.046086-0 PB Microbiology Society, SN 1465-2099, AB Papillomaviruses (PVs) have been widely identified among vertebrates, but have not yet been reported to infect yaks. We report, for the first time, a novel deltapapillomavirus that was associated with fibropapilloma in yak herds on the Qinghai–Tibetan Plateau. Six skin papilloma samples were collected and examined using histopathology, immunohistochemistry and PCR assays. The samples were identified as fibropapilloma and were found to contain PV antigens. Sequencing of diagnostic PCR products and the full-length genome revealed that all samples were infected with the same PV type. The whole virus genome was 7946 bp in length and possessed the common PV genomic organization. The virus was identified as a novel PV type and designated Bos grunniens papillomavirus type 1 (BgPV-1) based on the nucleotide sequence alignment of the L1 ORF. It is classified in the Delta-4 species of the genus Deltapapillomavirus based on phylogenetic analysis of the L1 ORF. Identification of this novel PV type provides further information about the pathology, development of diagnostic methods and evolutionary studies of the family Papillomaviridae., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.046086-0