RT Journal Article SR Electronic(1) A1 Matej, Radoslav A1 Olejar, Tomas A1 Janouskova, Olga A1 Holada, KarelYR 2012 T1 Deletion of protease-activated receptor 2 prolongs survival of scrapie-inoculated mice JF Journal of General Virology, VO 93 IS 9 SP 2057 OP 2061 DO https://doi.org/10.1099/vir.0.043877-0 PB Microbiology Society, SN 1465-2099, AB Proteinase-activated receptor 2 (PAR2) has recently been identified to be a possible modulator of neurodegeneration. To investigate whether PAR2 plays a role in prion infection, we inoculated PAR2-deficient (PAR2−/−) and wild-type (WT) mice intracerebrally with the Rocky Mountain Laboratory strain of scrapie. PAR2−/− mice demonstrated a delayed onset of clinical symptoms, including weight loss, and demonstrated moderate but highly significant prolongation of survival over WT controls. Concomitantly, no apparent differences in brain pathology, infectivity or features of brain prion protein between deceased WT and PAR2−/− mice were found. Our study suggests that PAR2 deletion modulates dynamics of the disease without gross perturbation of its pathogenesis., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.043877-0