RT Journal Article SR Electronic(1) A1 Borggren, Marie A1 Navér, Lars A1 Casper, Charlotte A1 Ehrnst, Anneka A1 Jansson, MarianneYR 2013 T1 R5 human immunodeficiency virus type 1 with efficient DC-SIGN use is not selected for early after birth in vertically infected children JF Journal of General Virology, VO 94 IS 4 SP 767 OP 773 DO https://doi.org/10.1099/vir.0.043620-0 PB Microbiology Society, SN 1465-2099, AB The binding of human immunodeficiency virus (HIV) to C-type lectin receptors may result in either enhanced trans-infection of T-cells or virus degradation. We have investigated the efficacy of HIV-1 utilization of DC-SIGN, a C-type lectin receptor, in the setting of intrauterine or intrapartum mother-to-child transmission (MTCT). Viruses isolated from HIV-1-infected mothers at delivery and from their vertically infected children both shortly after birth and later during the progression of the disease were analysed for their use of DC-SIGN, binding and ability to trans-infect. DC-SIGN use of a child’s earlier virus isolate tended to be reduced as compared with that of the corresponding maternal isolate. Furthermore, the children’s later isolate displayed enhanced DC-SIGN utilization compared with that of the corresponding earlier virus. These results were also supported in head-to-head competition assays and suggest that HIV-1 variants displaying efficient DC-SIGN use are not selected for during intrauterine or intrapartum MTCT. However, viruses with increased DC-SIGN use may evolve later in paediatric HIV-1 infections., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.043620-0