1887

Abstract

Xi’an, the capital of Shaanxi province, located in north-west China, is one of the major endemic areas for haemorrhagic fever with renal syndrome (HFRS). In this study, the epidemiological data of HFRS in Xi’an from 1959 to 2010, especially in the past ten years (2001–2010), were surveyed. The features of hantavirus (HV) host carriers, the molecular characteristics of the HV S gene from hosts and patients, and the genome of the viral isolate were also investigated. Data showed that there might be a ten-year cycle of HFRS in Xi’an. Although the main population group infected over the past ten years was still the 16–59-year-old male farmers, the composition of the population and geographical distribution of HFRS cases have changed slowly, accompanied by the development of environmental and socio-economic situations. remains the dominant host of HV. The HV strains from host rodents and patients in Xi’an belonged to the Hantaan virus (HTNV); no Seoul virus strains were found. Phylogenetic analysis of the small segments of strains taken from hosts and patients, and the whole genome of a viral isolate showed that the virus circulating in Xi’an had high similarity to Guizhou strains. The study also indicated that the vaccine candidate strain A16 isolated during the past century in Xi’an might be a recombinant strain of HTNV and the Amur virus, thus it may not be an optimal vaccine strain.

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2012-10-01
2020-01-20
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References

  1. Avsic-Zupanc T. , Nemirov K. , Petrovec M. , Trilar T. , Poljak M. , Vaheri A. , Plyusnin A. . ( 2000; ). Genetic analysis of wild-type Dobrava hantavirus in Slovenia: co-existence of two distinct genetic lineages within the same natural focus. . J Gen Virol 81:, 1747–1755.[PubMed]
    [Google Scholar]
  2. Baek L. J. , Kariwa H. , Lokugamage K. , Yoshimatsu K. , Arikawa J. , Takashima I. , Kang J. I. , Moon S. S. , Chung S. Y. . & other authors ( 2006; ). Soochong virus: an antigenically and genetically distinct hantavirus isolated from Apodemus peninsulae in Korea. . J Med Virol 78:, 290–297. [CrossRef] [PubMed]
    [Google Scholar]
  3. Beaty B. J. , Sundin D. R. , Chandler L. J. , Bishop D. H. . ( 1985; ). Evolution of bunyaviruses by genome reassortment in dually infected mosquitoes (Aedes triseriatus). . Science 230:, 548–550. [CrossRef] [PubMed]
    [Google Scholar]
  4. Brummer-Korvenkontio M. , Henttonen H. , Vaheri A. . ( 1982; ). Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica. . Scand J Infect Dis Suppl 36:, 88–91.[PubMed]
    [Google Scholar]
  5. Chen H. X. . ( 2001; ). Hemorrhagic Fever with Renal Syndrome Studies on the Surveillance and Application of Vaccine. Hong Kong:: Hong Kong Medical Publisher;.
    [Google Scholar]
  6. Chen H. X. , Qiu F. X. . ( 1993; ). Epidemiologic surveillance on the hemorrhagic fever with renal syndrome in China. . Chin Med J (Engl) 106:, 857–863.[PubMed]
    [Google Scholar]
  7. Clement J. , Lameire N. , Keyaerts E. , Maes P. , Van Ranst M. . ( 2003; ). Hantavirus infections in Europe. . Lancet Infect Dis 3:, 752–753, discussion 753–754. [CrossRef] [PubMed]
    [Google Scholar]
  8. Deyde V. M. , Khristova M. L. , Rollin P. E. , Ksiazek T. G. , Nichol S. T. . ( 2006; ). Crimean-Congo hemorrhagic fever virus genomics and global diversity. . J Virol 80:, 8834–8842. [CrossRef] [PubMed]
    [Google Scholar]
  9. Easterbrook J. D. , Klein S. L. . ( 2008; ). Immunological mechanisms mediating hantavirus persistence in rodent reservoirs. . PLoS Pathog 4:, e1000172. [CrossRef] [PubMed]
    [Google Scholar]
  10. Hardestam J. , Karlsson M. , Falk K. I. , Olsson G. , Klingström J. , Lundkvist A. . ( 2008; ). Puumala hantavirus excretion kinetics in bank voles (Myodes glareolus). . Emerg Infect Dis 14:, 1209–1215. [CrossRef] [PubMed]
    [Google Scholar]
  11. Henderson W. W. , Monroe M. C. , St Jeor S. C. , Thayer W. P. , Rowe J. E. , Peters C. J. , Nichol S. T. . ( 1995; ). Naturally occurring Sin Nombre virus genetic reassortants. . Virology 214:, 602–610. [CrossRef] [PubMed]
    [Google Scholar]
  12. Hjelle B. , Yates T. . ( 2001; ). Modeling hantavirus maintenance and transmission in rodent communities. . Curr Top Microbiol Immunol 256:, 77–90. [CrossRef] [PubMed]
    [Google Scholar]
  13. Jiang J. F. , Zhang W. Y. , Wu X. M. , Zhang P. H. , Cao W. C. . ( 2007; ). Soochong virus and Amur virus might be the same entities of hantavirus. . J Med Virol 79:, 1792–1795. [CrossRef] [PubMed]
    [Google Scholar]
  14. Jonsson C. B. , Figueiredo L. T. , Vapalahti O. . ( 2010; ). A global perspective on hantavirus ecology, epidemiology, and disease. . Clin Microbiol Rev 23:, 412–441. [CrossRef] [PubMed]
    [Google Scholar]
  15. Kang W. , Huang C. , Bai X. , Yang W. , Li G. . ( 2002; ). [A preliminary genetic reassortment between Hantaan virus and Seoul virus strains]. . Zhonghua Liu Xing Bing Xue Za Zhi 23:, 46–49 (in Chinese).[PubMed]
    [Google Scholar]
  16. Kariwa H. , Yoshimatsu K. , Sawabe J. , Yokota E. , Arikawa J. , Takashima I. , Fukushima H. , Lundkvist A. , Shubin F. N. . & other authors ( 1999; ). Genetic diversities of hantaviruses among rodents in Hokkaido, Japan and Far East Russia. . Virus Res 59:, 219–228. [CrossRef] [PubMed]
    [Google Scholar]
  17. Khaiboullina S. F. , Morzunov S. P. , St Jeor S. C. . ( 2005; ). Hantaviruses: molecular biology, evolution and pathogenesis. . Curr Mol Med 5:, 773–790. [CrossRef] [PubMed]
    [Google Scholar]
  18. Klempa B. , Schmidt H. A. , Ulrich R. , Kaluz S. , Labuda M. , Meisel H. , Hjelle B. , Krüger D. H. . ( 2003; ). Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A. flavicollis in nature. . J Virol 77:, 804–809. [CrossRef] [PubMed]
    [Google Scholar]
  19. Lee H. W. , Johnson K. M. . ( 1982; ). Laboratory-acquired infections with Hantaan virus, the etiologic agent of Korean hemorrhagic fever. . J Infect Dis 146:, 645–651. [CrossRef] [PubMed]
    [Google Scholar]
  20. Li D. , Schmaljohn A. L. , Anderson K. , Schmaljohn C. S. . ( 1995; ). Complete nucleotide sequences of the M and S segments of two hantavirus isolates from California: evidence for reassortment in nature among viruses related to hantavirus pulmonary syndrome. . Virology 206:, 973–983. [CrossRef] [PubMed]
    [Google Scholar]
  21. Li X. , Yang W. , Hang C. , Li G. , Wang J. . ( 2002; ). [Complete genome sequence of 84FLi, a Hantaan virus strain isolated from the liver of fetus aborted by a pregnant women with hemmorrhagic fever with renal syndrome]. . Zhonghua Yi Xue Za Zhi 82:, 981–985 (in Chinese).
    [Google Scholar]
  22. McCaughey C. , Hart C. A. . ( 2000; ). Hantaviruses. . J Med Microbiol 49:, 587–599.[PubMed]
    [Google Scholar]
  23. McElroy A. K. , Smith J. M. , Hooper J. W. , Schmaljohn C. S. . ( 2004; ). Andes virus M genome segment is not sufficient to confer the virulence associated with Andes virus in Syrian hamsters. . Virology 326:, 130–139. [CrossRef] [PubMed]
    [Google Scholar]
  24. Nemirov K. , Vapalahti O. , Lundkvist A. , Vasilenko V. , Golovljova I. , Plyusnina A. , Niemimaa J. , Laakkonen J. , Henttonen H. . & other authors ( 1999; ). Isolation and characterization of Dobrava hantavirus carried by the striped field mouse (Apodemus agrarius) in Estonia. . J Gen Virol 80:, 371–379.[PubMed]
    [Google Scholar]
  25. Nunes M. R. , Travassos da Rosa A. P. , Weaver S. C. , Tesh R. B. , Vasconcelos P. F. . ( 2005; ). Molecular epidemiology of group C viruses (Bunyaviridae, Orthobunyavirus) isolated in the Americas. . J Virol 79:, 10561–10570. [CrossRef] [PubMed]
    [Google Scholar]
  26. Plyusnin A. , Morzunov S. P. . ( 2001; ). Virus evolution and genetic diversity of hantaviruses and their rodent hosts. . Curr Top Microbiol Immunol 256:, 47–75. [CrossRef] [PubMed]
    [Google Scholar]
  27. Rizvanov A. A. , Khaiboullina S. F. , St Jeor S. . ( 2004; ). Development of reassortant viruses between pathogenic hantavirus strains. . Virology 327:, 225–232. [CrossRef] [PubMed]
    [Google Scholar]
  28. Rodriguez L. L. , Owens J. H. , Peters C. J. , Nichol S. T. . ( 1998; ). Genetic reassortment among viruses causing hantavirus pulmonary syndrome. . Virology 242:, 99–106. [CrossRef] [PubMed]
    [Google Scholar]
  29. Sall A. A. , Zanotto P. M. , Sene O. K. , Zeller H. G. , Digoutte J. P. , Thiongane Y. , Bouloy M. . ( 1999; ). Genetic reassortment of Rift Valley fever virus in nature. . J Virol 73:, 8196–8200.[PubMed]
    [Google Scholar]
  30. Schilling S. , Emmerich P. , Klempa B. , Auste B. , Schnaith E. , Schmitz H. , Krüger D. H. , Günther S. , Meisel H. . ( 2007; ). Hantavirus disease outbreak in Germany: limitations of routine serological diagnostics and clustering of virus sequences of human and rodent origin. . J Clin Microbiol 45:, 3008–3014. [CrossRef] [PubMed]
    [Google Scholar]
  31. Schmaljohn C. , Hjelle B. . ( 1997; ). Hantaviruses: a global disease problem. . Emerg Infect Dis 3:, 95–104. [CrossRef] [PubMed]
    [Google Scholar]
  32. She J. J . . ( 2003; ). Study on diversity and distribution of rodents in Shaanxi Province. . China J Vector Biol & Control 14:, 4.
    [Google Scholar]
  33. Smadel J. E. . ( 1953; ). Epidemic hemorrhagic fever. . Am J Public Health Nations Health 43:, 1327–1330. [CrossRef] [PubMed]
    [Google Scholar]
  34. Song G. . ( 1999; ). Epidemiological progresses of hemorrhagic fever with renal syndrome in China. . Chin Med J (Engl) 112:, 472–477.[PubMed]
    [Google Scholar]
  35. Sun L. , Zhang Y. Z. , Li L. H. , Zhang Y. P. , Zhang A. M. , Hao Z. Y. , Sun J. W. , Chen H. X. . ( 2005; ). [Genetics subtypes and distribution of Seoul virus in Henan]. . Zhonghua Liu Xing Bing Xue Za Zhi 26:, 578–582 (in Chinese).[PubMed]
    [Google Scholar]
  36. Täger Frey M. , Vial P. C. , Castillo C. H. , Godoy P. M. , Hjelle B. , Ferrés M. G. . ( 2003; ). Hantavirus prevalence in the IX Region of Chile. . Emerg Infect Dis 9:, 827–832. [CrossRef] [PubMed]
    [Google Scholar]
  37. Tamura K. , Peterson D. , Peterson N. , Stecher G. , Nei M. , Kumar S. . ( 2011; ). mega5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. . Mol Biol Evol 28:, 2731–2739. [CrossRef] [PubMed]
    [Google Scholar]
  38. Urquidi V. , Bishop D. H. . ( 1992; ). Non-random reassortment between the tripartite RNA genomes of La Crosse and snowshoe hare viruses. . J Gen Virol 73:, 2255–2265. [CrossRef] [PubMed]
    [Google Scholar]
  39. Vapalahti K. , Paunio M. , Brummer-Korvenkontio M. , Vaheri A. , Vapalahti O. . ( 1999; ). Puumala virus infections in Finland: increased occupational risk for farmers. . Am J Epidemiol 149:, 1142–1151. [CrossRef] [PubMed]
    [Google Scholar]
  40. Wang H. , Yoshimatsu K. , Ebihara H. , Ogino M. , Araki K. , Kariwa H. , Wang Z. , Luo Z. , Li D. . & other authors ( 2000; ). Genetic diversity of hantaviruses isolated in China and characterization of novel hantaviruses isolated from Niviventer confucianus and Rattus rattus . . Virology 278:, 332–345. [CrossRef] [PubMed]
    [Google Scholar]
  41. Wang S. W. , Hang C. S. , Wang H. , Xie Y. X. , Ma B. J. . ( 2002; ). [Genotype and clade distribution of hantaviruses in China]. . Chin J Virol 18:, 211–216 (in Chinese). [CrossRef] [PubMed]
    [Google Scholar]
  42. Yao Z. H. , Dong G.-M. , Yu Y. X. , Jia K. , Yan Y. . ( 2001; ). Molecular characteristics of the seed virus of HFRS candidate vaccine A16 strain. . Virol Sin 16:, 315–320.
    [Google Scholar]
  43. Yashina L. , Mishin V. , Zdanovskaya N. , Schmaljohn C. , Ivanov L. . ( 2001; ). A newly discovered variant of a hantavirus in Apodemus peninsulae, far Eastern Russia. . Emerg Infect Dis 7:, 912–913.[PubMed] [CrossRef]
    [Google Scholar]
  44. Zhang Y. Z. , Xiao D. L. , Wang Y. , Wang H. X. , Sun L. , Tao X. X. , Qu Y. G. . ( 2004; ). [The epidemic characteristics and preventive measures of hemorrhagic fever with syndromes in China]. . Zhonghua Liu Xing Bing Xue Za Zhi 25:, 466–469 (in Chinese). [PubMed]
    [Google Scholar]
  45. Zhang Y. Z. , Zou Y. , Yao L. S. , Hu G. W. , Du Z. S. , Jin L. Z. , Liu Y. Y. , Wang H. X. , Chen X. . & other authors ( 2007; ). Isolation and characterization of hantavirus carried by Apodemus peninsulae in Jilin, China. . J Gen Virol 88:, 1295–1301. [CrossRef] [PubMed]
    [Google Scholar]
  46. Zhang Y. Z. , Zhang F. X. , Wang J. B. , Zhao Z. W. , Li M. H. , Chen H. X. , Zou Y. , Plyusnin A. . ( 2009; ). Hantaviruses in rodents and humans, Inner Mongolia Autonomous Region, China. . Emerg Infect Dis 15:, 885–891. [CrossRef] [PubMed]
    [Google Scholar]
  47. Zhang Y. Z. , Zou Y. , Fu Z. F. , Plyusnin A. . ( 2010; ). Hantavirus infections in humans and animals, China. . Emerg Infect Dis 16:, 1195–1203. [CrossRef] [PubMed]
    [Google Scholar]
  48. Zou Y. , Hu J. , Wang Z. X. , Wang D. M. , Yu C. , Zhou J. Z. , Fu Z. F. , Zhang Y. Z. . ( 2008; ). Genetic characterization of hantaviruses isolated from Guizhou, China: evidence for spillover and reassortment in nature. . J Med Virol 80:, 1033–1041. [CrossRef] [PubMed]
    [Google Scholar]
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