1887

Abstract

The incursion of the human pandemic influenza A virus H1N1 (2009) (H1N1 pdm) into pig populations and its ongoing co-circulation with endemic swine influenza viruses (SIVs) has yielded distinct human–porcine reassortant virus lineages. The haemagglutinin (HA) gene of H1N1 pdm was detected in 41 influenza virus-positive samples from seven swine herds in north-west Germany in 2011. Eight of these samples yielded virus that carried SIV-derived neuraminidase N2 of three different porcine lineages in an H1N1 pdm backbone. The HA sequences of these viruses clustered in two distinct groups and were distinguishable from human and other porcine H1 pdm by a unique set of eight non-synonymous mutations. In contrast to the human population, where H1N1 pdm replaced seasonal H1N1, this virus seems to co-circulate and interact more intensely with endemic SIV lineages, giving rise to reassortants with as-yet-unknown biological properties and undetermined risks for public health.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.042648-0
2012-08-01
2020-12-04
Loading full text...

Full text loading...

/deliver/fulltext/jgv/93/8/1658.html?itemId=/content/journal/jgv/10.1099/vir.0.042648-0&mimeType=html&fmt=ahah

References

  1. Ali A., Khatri M., Wang L., Saif Y. M., Lee C. W. 2012; Identification of swine H1N2/pandemic H1N1 reassortant influenza virus in pigs, United States. Vet Microbiol 158:60–68 [CrossRef][PubMed]
    [Google Scholar]
  2. Bálint A., Metreveli G., Widén F., Zohari S., Berg M., Isaksson M., Renström L. H. M., Wallgren P., Belák S.other authors 2009; The first Swedish H1N2 swine influenza virus isolate represents an uncommon reassortant. Virol J 6:180–185 [CrossRef][PubMed]
    [Google Scholar]
  3. Brookes S. M., Núñez A., Choudhury B., Matrosovich M., Essen S. C., Clifford D., Slomka M. J., Kuntz-Simon G., Garcon F.other authors 2010; Replication, pathogenesis and transmission of pandemic (H1N1) 2009 virus in non-immune pigs. PLoS ONE 5:e9068 [CrossRef][PubMed]
    [Google Scholar]
  4. Ducatez M. F., Sonnberg S., Hall R. J., Peacey M., Ralston J., Webby R. J., Huang Q. S. 2010; Genotyping assay for the identification of 2009–2010 pandemic and seasonal H1N1 influenza virus reassortants. J Virol Methods 168:78–81 [CrossRef][PubMed]
    [Google Scholar]
  5. Ducatez M. F., Hause B., Stigger-Rosser E., Darnell D., Corzo C., Juleen K., Simonson R., Brockwell-Staats C., Rubrum A.other authors 2011; Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, United States. Emerg Infect Dis 17:1624–1629 [CrossRef][PubMed]
    [Google Scholar]
  6. Fan X., Zhu H., Zhou B., Smith D. K., Chen X., Lam T. T. Y., Poon L. L. M., Peiris M., Guan Y. 2012; Emergence and dissemination of a swine H3N2 reassortant influenza virus with 2009 pandemic H1N1 genes in pigs in China. J Virol 86:2375–2378 [CrossRef][PubMed]
    [Google Scholar]
  7. Han J. Y., Park S. J., Kim H. K., Rho S., Nguyen G. V., Song D., Kang B. K., Moon H. J., Yeom M. J., Park B. K. 2012; Identification of reassortant pandemic H1N1 influenza virus in Korean pigs. J Microbiol Biotechnol 22:699–707 [CrossRef][PubMed]
    [Google Scholar]
  8. Hoffmann B., Harder T., Lange E., Kalthoff D., Reimann I., Grund C., Oehme R., Vahlenkamp T. W., Beer M. 2010; New real-time reverse transcriptase polymerase chain reactions facilitate detection and differentiation of novel A/H1N1 influenza virus in porcine and human samples. Berl Munch Tierarztl Wochenschr 123:286–292[PubMed]
    [Google Scholar]
  9. Howard W. A., Essen S. C., Strugnell B. W., Russell C., Barass L., Reid S. M., Brown I. H. 2011; Reassortant pandemic (H1N1) 2009 virus in pigs, United Kingdom. Emerg Infect Dis 17:1049–1052 [CrossRef][PubMed]
    [Google Scholar]
  10. Igarashi M., Ito K., Yoshida R., Tomabechi D., Kida H., Takada A. 2010; Predicting the antigenic structure of the pandemic (H1N1) 2009 influenza virus hemagglutinin. PLoS ONE 5:e8553 [CrossRef][PubMed]
    [Google Scholar]
  11. Irvine R. M., Brown I. H. 2009; Novel H1N1 influenza in people: global spread from an animal source?. Vet Rec 164:577–578 [CrossRef]
    [Google Scholar]
  12. Kitikoon P., Sreta D., Nuntawan Na Ayudhya S., Wongphatcharachai M., Lapkuntod J., Prakairungnamthip D., Bunpapong N., Suradhat S., Thanawongnuwech R., Amonsin A. 2011; Brief report: molecular characterization of a novel reassorted pandemic H1N1 2009 in Thai pigs. Virus Genes 43:1–5 [CrossRef][PubMed]
    [Google Scholar]
  13. Lange E., Kalthoff D., Blohm U., Teifke J. P., Breithaupt A., Maresch C., Starick E., Fereidouni S., Hoffmann B.other authors 2009; Pathogenesis and transmission of the novel swine-origin influenza virus A/H1N1 after experimental infection of pigs. J Gen Virol 90:2119–2123 [CrossRef][PubMed]
    [Google Scholar]
  14. Liu Q., Ma J., Liu H., Qi W., Anderson J., Henry S. C., Hesse R. A., Richt J. A., Ma W. 2012; Emergence of novel reassortant H3N2 swine influenza viruses with the 2009 pandemic H1N1 genes in the United States. Arch Virol 157:555–562 [CrossRef][PubMed]
    [Google Scholar]
  15. Moreno A., Di Trani L., Faccini S., Vaccari G., Nigrelli D., Boniotti M. B., Falcone E., Boni A., Chiapponi C.other authors 2011; Novel H1N2 swine influenza reassortant strain in pigs derived from the pandemic H1N1/2009 virus. Vet Microbiol 149:472–477 [CrossRef][PubMed]
    [Google Scholar]
  16. Moreno A., Chiapponi C., Boniotti M. B., Sozzi E., Foni E., Barbieri I., Zanoni M. G., Faccini S., Lelli D., Cordioli P. 2012; Genomic characterization of H1N2 swine influenza viruses in Italy. Vet Microbiol 156:265–276 [CrossRef][PubMed]
    [Google Scholar]
  17. Myers K. P., Olsen C. W., Gray G. C. 2007; Cases of swine influenza in humans: a review of the literature. Clin Infect Dis 44:1084–1088 [CrossRef][PubMed]
    [Google Scholar]
  18. Pereda A., Rimondi A., Cappuccio J., Sanguinetti R., Angel M., Ye J., Sutton T., Dibárbora M., Olivera V.other authors 2011; Evidence of reassortment of pandemic H1N1 influenza virus in swine in Argentina: are we facing the expansion of potential epicenters of influenza emergence?. Influenza Other Respir Viruses 5:409–412 [CrossRef][PubMed]
    [Google Scholar]
  19. Shinde V., Bridges C. B., Uyeki T. M., Shu B., Balish A., Xu X., Lindstrom S., Gubareva L. V., Deyde V.other authors 2009; Triple-reassortant swine influenza A (H1) in humans in the United States, 2005–2009. N Engl J Med 360:2616–2625 [CrossRef][PubMed]
    [Google Scholar]
  20. Soundararajan V., Tharakaraman K., Raman R., Raguram S., Shriver Z., Sasisekharan V., Sasisekharan R. 2009; Extrapolating from sequence – the 2009 H1N1 ‘swine’ influenza virus. Nat Biotechnol 27:510–513 [CrossRef][PubMed]
    [Google Scholar]
  21. Starick E., Fereidouni S. R., Lange E., Grund C., Vahlenkamp T., Beer M., Harder T. C. 2011a; Analysis of influenza A viruses of subtype H1 from wild birds, turkeys and pigs in Germany reveals interspecies transmission events. Influenza Other Respir Viruses 5:276–284 [CrossRef][PubMed]
    [Google Scholar]
  22. Starick E., Lange E., Fereidouni S., Bunzenthal C., Höveler R., Kuczka A., grosse Beilage E., Hamann H. P., Klingelhöfer I.other authors 2011b; Reassorted pandemic (H1N1) 2009 influenza A virus discovered from pigs in Germany. J Gen Virol 92:1184–1188 [CrossRef][PubMed]
    [Google Scholar]
  23. Tremblay D., Allard V., Doyon J. F., Bellehumeur C., Spearman J. G., Harel J., Gagnon C. A. 2011; Emergence of a new swine H3N2 and pandemic (H1N1) 2009 influenza A virus reassortant in two Canadian animal populations, mink and swine. J Clin Microbiol 49:4386–4390 [CrossRef][PubMed]
    [Google Scholar]
  24. Van Poucke S. G., Nicholls J. M., Nauwynck H. J., Van Reeth K. 2010; Replication of avian, human and swine influenza viruses in porcine respiratory explants and association with sialic acid distribution. Virol J 7:38–52 [CrossRef][PubMed]
    [Google Scholar]
  25. Vijaykrishna D., Poon L. L. M., Zhu H. C., Ma S. K., Li O. T. W., Cheung C. L., Smith G. J. D., Peiris J. S. M., Guan Y. 2010; Reassortment of pandemic H1N1/2009 influenza A virus in swine. Science 328:1529 [CrossRef][PubMed]
    [Google Scholar]
  26. WHO 2011; Influenza virus activity in the world. Geneva, Switzerland: World Health Organization.. http://www.who.int/influenza/gisrs_laboratory/updates/summaryreport/en/index.html
  27. Zhu H., Zhou B., Fan X., Lam T. T. Y., Wang J., Chen A., Chen X., Chen H., Webster R. G.other authors 2011; Novel reassortment of Eurasian avian-like and pandemic/2009 influenza viruses in swine: infectious potential for humans. J Virol 85:10432–10439 [CrossRef][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.042648-0
Loading
/content/journal/jgv/10.1099/vir.0.042648-0
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error