Experimental infection and natural contact exposure of ferrets with canine influenza virus (H3N2) Free

Abstract

Epidemics of H3N2 canine influenza virus (CIV) among dogs in South Korea and southern China have raised concern over the potential for zoonotic transmission of these viruses. Here, we analysed the pathogenesis and transmissibility of H3N2 CIV in ferret. H3N2 CIV replicated efficiently in the respiratory system of inoculated ferrets and caused acute necrotizing bronchioalveolitis and non-suppurative encephalitis. Transmission of H3N2 CIV was detected in three of six ferrets co-housed with inoculated ferrets, but no viruses were detected in second-contact ferrets. These findings show that H3N2 CIV has the capacity to replicate in and transmit partially among co-housed ferrets and underscore the need for continued public health surveillance.

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2013-02-01
2024-03-28
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References

  1. Barnard D. L. 2009; Animal models for the study of influenza pathogenesis and therapy. Antiviral Res 82:A110–A122 [View Article][PubMed]
    [Google Scholar]
  2. Belser J. A., Lu X., Maines T. R., Smith C., Li Y., Donis R. O., Katz J. M., Tumpey T. M. 2007; Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans. J Virol 81:11139–11147 [View Article][PubMed]
    [Google Scholar]
  3. Belser J. A., Szretter K. J., Katz J. M., Tumpey T. M. 2009; Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses. Adv Virus Res 73:55–97 [View Article][PubMed]
    [Google Scholar]
  4. Cohen J. 2012; Avian influenza. The limits of avian flu studies in ferrets. Science 335:512–513 [View Article][PubMed]
    [Google Scholar]
  5. Crawford P. C., Dubovi E. J., Castleman W. L., Stephenson I., Gibbs E. P., Chen L., Smith C., Hill R. C., Ferro P.other authors 2005; Transmission of equine influenza virus to dogs. Science 310:482–485 [View Article][PubMed]
    [Google Scholar]
  6. de Jong M. D., Bach V. C., Phan T. Q., Vo M. H., Tran T. T., Nguyen B. H., Beld M., Le T. P., Truong H. K.other authors 2005; Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma. N Engl J Med 352:686–691 [View Article][PubMed]
    [Google Scholar]
  7. Gambotto A., Barratt-Boyes S. M., de Jong M. D., Neumann G., Kawaoka Y. 2008; Human infection with highly pathogenic H5N1 influenza virus. Lancet 371:1464–1475 [View Article][PubMed]
    [Google Scholar]
  8. Kwon D., Shin K., Kim S., Ha Y., Choi J. H., Yang J. S., Lee J. Y., Chae C., Oh H. B., Kang C. 2010; Replication and pathogenesis of the pandemic (H1N1) 2009 influenza virus in mammalian models. J Microbiol 48:657–662 [View Article][PubMed]
    [Google Scholar]
  9. Lee C., Song D., Kang B., Kang D., Yoo J., Jung K., Na G., Lee K., Park B., Oh J. 2009; A serological survey of avian origin canine H3N2 influenza virus in dogs in Korea. Vet Microbiol 137:359–362 [View Article][PubMed]
    [Google Scholar]
  10. Lee H. J., Kwon J. S., Lee D. H., Lee Y. N., Youn H. N., Lee Y. J., Kim M. C., Jeong O. M., Kang H. M.other authors 2010a; Continuing evolution and interspecies transmission of influenza viruses in live bird markets in Korea. Avian Dis 54:Suppl.738–748 [View Article][PubMed]
    [Google Scholar]
  11. Lee Y. N., Lee H. J., Lee D. H., Kim J. H., Park H. M., Nahm S. S., Lee J. B., Park S. Y., Choi I. S., Song C. S. 2011; Severe canine influenza in dogs correlates with hyperchemokinemia and high viral load. Virology 417:57–63 [View Article][PubMed]
    [Google Scholar]
  12. Li S., Shi Z., Jiao P., Zhang G., Zhong Z., Tian W., Long L. P., Cai Z., Zhu X.other authors 2010; Avian-origin H3N2 canine influenza A viruses in southern China. Infect Genet Evol 10:1286–1288 [View Article][PubMed]
    [Google Scholar]
  13. Maher J. A., DeStefano J. 2004; The ferret: an animal model to study influenza virus. Lab Anim (NY) 33:50–53 [View Article][PubMed]
    [Google Scholar]
  14. Maines T. R., Lu X. H., Erb S. M., Edwards L., Guarner J., Greer P. W., Nguyen D. C., Szretter K. J., Chen L. M.other authors 2005; Avian influenza (H5N1) viruses isolated from humans in Asia in 2004 exhibit increased virulence in mammals. J Virol 79:11788–11800 [View Article][PubMed]
    [Google Scholar]
  15. Maines T. R., Chen L.-M., Matsuoka Y., Chen H., Rowe T., Ortin J., Falcón A., Hien N. T., Mai L. Q.other authors 2006; Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model. Proc Natl Acad Sci U S A 103:12121–12126 [View Article][PubMed]
    [Google Scholar]
  16. Maines T. R., Jayaraman A., Belser J. A., Wadford D. A., Pappas C., Zeng H., Gustin K. M., Pearce M. B., Viswanathan K.other authors 2009; Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice. Science 325:484–487[PubMed]
    [Google Scholar]
  17. Palese P., Wang T. T. 2012; H5N1 influenza viruses: facts, not fear. Proc Natl Acad Sci U S A 109:2211–2213 [View Article][PubMed]
    [Google Scholar]
  18. Shinya K., Makino A., Hatta M., Watanabe S., Kim J. H., Hatta Y., Gao P., Ozawa M., Le Q. M., Kawaoka Y. 2011; Subclinical brain injury caused by H5N1 influenza virus infection. J Virol 85:5202–5207 [View Article][PubMed]
    [Google Scholar]
  19. Song D., Kang B., Lee C., Jung K., Ha G., Kang D., Park S., Park B., Oh J. 2008; Transmission of avian influenza virus (H3N2) to dogs. Emerg Infect Dis 14:741–746 [View Article][PubMed]
    [Google Scholar]
  20. Song D., Lee C., Kang B., Jung K., Oh T., Kim H., Park B., Oh J. 2009; Experimental infection of dogs with avian-origin canine influenza A virus (H3N2). Emerg Infect Dis 15:56–58 [View Article][PubMed]
    [Google Scholar]
  21. Song D., Moon H. J., An D. J., Jeoung H. Y., Kim H., Yeom M. J., Hong M., Nam J. H., Park S. J.other authors 2012; A novel reassortant canine H3N1 influenza virus between pandemic H1N1 and canine H3N2 influenza viruses in Korea. J Gen Virol 93:551–554 [View Article][PubMed]
    [Google Scholar]
  22. Tanimura N., Tsukamoto K., Okamatsu M., Mase M., Imada T., Nakamura K., Kubo M., Yamaguchi S., Irishio W.other authors 2006; Pathology of fatal highly pathogenic H5N1 avian influenza virus infection in large-billed crows (Corvus macrorhynchos) during the 2004 outbreak in Japan. Vet Pathol 43:500–509 [View Article][PubMed]
    [Google Scholar]
  23. Van Hoeven N., Pappas C., Belser J. A., Maines T. R., Zeng H., García-Sastre A., Sasisekharan R., Katz J. M., Tumpey T. M. 2009; Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air. Proc Natl Acad Sci U S A 106:3366–3371 [View Article][PubMed]
    [Google Scholar]
  24. Yen H. L., Lipatov A. S., Ilyushina N. A., Govorkova E. A., Franks J., Yilmaz N., Douglas A., Hay A., Krauss S.other authors 2007; Inefficient transmission of H5N1 influenza viruses in a ferret contact model. J Virol 81:6890–6898 [View Article][PubMed]
    [Google Scholar]
  25. Zitzow L. A., Rowe T., Morken T., Shieh W. J., Zaki S., Katz J. M. 2002; Pathogenesis of avian influenza A (H5N1) viruses in ferrets. J Virol 76:4420–4429 [View Article][PubMed]
    [Google Scholar]
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