1887

Abstract

Recent studies indicate that human papillomaviruses (HPVs) from the genera and are abundant in the human oral cavity. We report the cloning and characterization of a 7304 bp HPV120 genome from the oral cavity that is related most closely to HPV23 (L1 ORF, 83.7 % similarity), clustering it in the genus PV). HPV120 contains five early and two late genes, but no E5 ORF. HPV120 was detected from heterogeneous human biological niches, including the oral cavity, eyebrow hairs, anal canal and penile, vulvar and perianal warts. Characterization of the clinical spectrum of HPV120 infections indicates a broader spectrum of epithelial tropism than appreciated previously for HPV types from the genus βPV.

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2012-08-01
2020-07-13
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References

  1. Agalliu I., Gern R., Leanza S., Burk R. D.. 2009; Associations of high-grade prostate cancer with BRCA1 and BRCA2 founder mutations. Clin Cancer Res15:1112–1120 [CrossRef][PubMed]
    [Google Scholar]
  2. Bernard H. U., Burk R. D., Chen Z., van Doorslaer K., Hausen H., de Villiers E. M.. 2010; Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology401:70–79 [CrossRef][PubMed]
    [Google Scholar]
  3. Bottalico D., Chen Z., Dunne A., Ostoloza J., McKinney S., Sun C., Schlecht N. F., Fatahzadeh M., Herrero R..other authors 2011; The oral cavity contains abundant known and novel human papillomaviruses from the Betapapillomavirus and Gammapapillomavirus genera. J Infect Dis204:787–792 [CrossRef][PubMed]
    [Google Scholar]
  4. Burk R. D., Chen Z., Harari A., Smith B. C., Kocjan B. J., Maver P. J., Poljak M.. 2011; Classification and nomenclature system for human Alphapapillomavirus variants: general features, nucleotide landmarks and assignment of HPV6 and HPV11 isolates to variant lineages. Acta Dermatovenerol Alp Panonica Adriat20:113–123[PubMed]
    [Google Scholar]
  5. Chen Z., Schiffman M., Herrero R., Desalle R., Anastos K., Segondy M., Sahasrabuddhe V. V., Gravitt P. E., Hsing A. W., Burk R. D.. 2011; Evolution and taxonomic classification of human papillomavirus 16 (HPV16)-related variant genomes: HPV31, HPV33, HPV35, HPV52, HPV58 and HPV67. PLoS ONE6:e20183 [CrossRef][PubMed]
    [Google Scholar]
  6. de Villiers E. M., Gunst K.. 2009; Characterization of seven novel human papillomavirus types isolated from cutaneous tissue, but also present in mucosal lesions. J Gen Virol90:1999–2004 [CrossRef][PubMed]
    [Google Scholar]
  7. Edgar R. C.. 2004; MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res32:1792–1797 [CrossRef][PubMed]
    [Google Scholar]
  8. Grice E. A., Kong H. H., Conlan S., Deming C. B., Davis J., Young A. C., Bouffard G. G., Blakesley R. W., Murray P. R..other authors 2009; Topographical and temporal diversity of the human skin microbiome. Science324:1190–1192 [CrossRef][PubMed]
    [Google Scholar]
  9. Jancar N., Kocjan B. J., Poljak M., Lunar M. M., Bokal E. V.. 2009; Distribution of human papillomavirus genotypes in women with cervical cancer in Slovenia. Eur J Obstet Gynecol Reprod Biol145:184–188 [CrossRef][PubMed]
    [Google Scholar]
  10. Kocjan B. J., Poljak M., Seme K., Potocnik M., Fujs K., Babic D. Z.. 2005; Distribution of human papillomavirus genotypes in plucked eyebrow hairs from Slovenian males with genital warts. Infect Genet Evol5:255–259 [CrossRef][PubMed]
    [Google Scholar]
  11. Kocjan B. J., Poljak M., Seme K.. 2010; Universal ProbeLibrary based real-time PCR assay for detection and confirmation of human papillomavirus genotype 52 infections. J Virol Methods163:492–494 [CrossRef][PubMed]
    [Google Scholar]
  12. Lehoux M., D’Abramo C. M., Archambault J.. 2009; Molecular mechanisms of human papillomavirus-induced carcinogenesis. Public Health Genomics12:268–280 [CrossRef][PubMed]
    [Google Scholar]
  13. Li N., Franceschi S., Howell-Jones R., Snijders P. J., Clifford G. M.. 2011; Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication. Int J Cancer128:927–935 [CrossRef][PubMed]
    [Google Scholar]
  14. Marur S., D’Souza G., Westra W. H., Forastiere A. A.. 2010; HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol11:781–789 [CrossRef][PubMed]
    [Google Scholar]
  15. McBride A. A.. 2008; Replication and partitioning of papillomavirus genomes. Adv Virus Res72:155–205 [CrossRef][PubMed]
    [Google Scholar]
  16. Milosevic M., Poljak M., Mlakar B.. 2010; Anal HPV infection in Slovenian men who have sex with men. Cent Eur J Med5:698–703 [CrossRef]
    [Google Scholar]
  17. Potocnik M., Kocjan B. J., Seme K., Poljak M.. 2007; Distribution of human papillomavirus (HPV) genotypes in genital warts from males in Slovenia. Acta Dermatovenerol Alp Panonica Adriat16:91–96, 98[PubMed]
    [Google Scholar]
  18. Stamatakis A.. 2006; RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Bioinformatics22:2688–2690 [CrossRef][PubMed]
    [Google Scholar]
  19. Tamura K., Peterson D., Peterson N., Stecher G., Nei M., Kumar S.. 2011; mega5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol Biol Evol28:2731–2739 [CrossRef][PubMed]
    [Google Scholar]
  20. Zheng Z. M., Baker C. C.. 2006; Papillomavirus genome structure, expression, and post-transcriptional regulation. Front Biosci11:2286–2302 [CrossRef][PubMed]
    [Google Scholar]
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