@article{mbs:/content/journal/jgv/10.1099/vir.0.041731-0, author = "Phan, Tung G. and Li, Linlin and O’Ryan, Miguel G. and Cortes, Hector and Mamani, Nora and Bonkoungou, Isidore J. O. and Wang, Chunling and Leutenegger, Christian M. and Delwart, Eric", title = "A third gyrovirus species in human faeces", journal= "Journal of General Virology", year = "2012", volume = "93", number = "6", pages = "1356-1361", doi = "https://doi.org/10.1099/vir.0.041731-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.041731-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Until 2011 the genus Gyrovirus in the family Circoviridae consisted of a single virus (Chicken anemia virus or CAV) causing a common immunosuppressive disease in chickens when a second gyrovirus (HGyV) was reported on the skin of 4 % of healthy humans. HGyV is very closely related to a recently described chicken gyrovirus, AGV2, suggesting that they belong to the same viral species. During a viral metagenomic analysis of 100 human faeces from children with diarrhoea in Chile we identified multiple known human pathogens (adenoviruses, enteroviruses, astroviruses, sapoviruses, noroviruses, parechoviruses and rotaviruses) and a novel gyrovirus species we named GyV3 sharing <63 % similarity with other gyrovirus proteins with evidence of recombination with CAV in its UTR. Gyroviridae consensus PCR revealed a high prevalence of CAV DNA in diarrhoea and normal faeces from Chilean children and faeces of USA cats and dogs, which may reflect consumption of CAV-infected/vaccinated chickens. Whether GyV3 can infect humans and/or chickens requires further studies.", }