1887

Abstract

Until 2011 the genus in the family consisted of a single virus (Chicken anemia virus or CAV) causing a common immunosuppressive disease in chickens when a second gyrovirus (HGyV) was reported on the skin of 4 % of healthy humans. HGyV is very closely related to a recently described chicken gyrovirus, AGV2, suggesting that they belong to the same viral species. During a viral metagenomic analysis of 100 human faeces from children with diarrhoea in Chile we identified multiple known human pathogens (adenoviruses, enteroviruses, astroviruses, sapoviruses, noroviruses, parechoviruses and rotaviruses) and a novel gyrovirus species we named GyV3 sharing <63 % similarity with other gyrovirus proteins with evidence of recombination with CAV in its UTR. consensus PCR revealed a high prevalence of CAV DNA in diarrhoea and normal faeces from Chilean children and faeces of USA cats and dogs, which may reflect consumption of CAV-infected/vaccinated chickens. Whether GyV3 can infect humans and/or chickens requires further studies.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.041731-0
2012-06-01
2020-07-03
Loading full text...

Full text loading...

/deliver/fulltext/jgv/93/6/1356.html?itemId=/content/journal/jgv/10.1099/vir.0.041731-0&mimeType=html&fmt=ahah

References

  1. Adair B. M.. 2000; Immunopathogenesis of chicken anemia virus infection. Dev Comp Immunol24:247–255 [CrossRef][PubMed]
    [Google Scholar]
  2. Bonkoungou I. J., Sanou I., Bon F., Benon B., Coulibaly S. O., Haukka K., Traoré A. S., Barro N.. 2010; Epidemiology of rotavirus infection among young children with acute diarrhoea in Burkina Faso. BMC Pediatr10:94 [CrossRef][PubMed]
    [Google Scholar]
  3. Craig M. I., Rimondi A., Delamer M., Sansalone P., König G., Vagnozzi A., Pereda A.. 2009; Molecular characterization of chicken infectious anemia virus circulating in Argentina during 2007. Avian Dis53:331–335 [CrossRef][PubMed]
    [Google Scholar]
  4. Dos Santos H. F., Knak M. B., de Castro F. L., Slongo J., Ritterbusch G. A., Klein T. A., Esteves P. A., Silva A. D., Trevisol I. M.. other authors 2012; Variants of the recently discovered avian gyrovirus 2 are detected in Southern Brazil and The Netherlands. Vet Microbiol155:230–236[PubMed][CrossRef]
    [Google Scholar]
  5. Ducatez M. F., Owoade A. A., Abiola J. O., Muller C. P.. 2006; Molecular epidemiology of chicken anemia virus in Nigeria. Arch Virol151:97–111 [CrossRef][PubMed]
    [Google Scholar]
  6. Eltahir Y. M., Qian K., Jin W., Qin A.. 2011a; Analysis of chicken anemia virus genome: evidence of intersubtype recombination. Virol J8:512 [CrossRef][PubMed]
    [Google Scholar]
  7. Eltahir Y. M., Qian K., Jin W., Wang P., Qin A.. 2011b; Molecular epidemiology of chicken anemia virus in commercial farms in China. Virol J8:145 [CrossRef][PubMed]
    [Google Scholar]
  8. Hailemariam Z., Omar A. R., Hair-Bejo M., Giap T. C.. 2008; Detection and characterization of chicken anemia virus from commercial broiler breeder chickens. Virol J5:128 [CrossRef][PubMed]
    [Google Scholar]
  9. Ilyina T. V., Koonin E. V.. 1992; Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria. Nucleic Acids Res20:3279–3285 [CrossRef][PubMed]
    [Google Scholar]
  10. Kim H. R., Kwon Y. K., Bae Y. C., Oem J. K., Lee O. S.. 2010; Molecular characterization of chicken infectious anemia viruses detected from breeder and broiler chickens in South Korea. Poult Sci89:2426–2431 [CrossRef][PubMed]
    [Google Scholar]
  11. Kimura M.. 1980; A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol16:111–120 [CrossRef][PubMed]
    [Google Scholar]
  12. Li L., Kapoor A., Slikas B., Bamidele O. S., Wang C., Shaukat S., Masroor M. A., Wilson M. L., Ndjango J. B.. other authors 2010a; Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces. J Virol84:1674–1682 [CrossRef][PubMed]
    [Google Scholar]
  13. Li L., Victoria J. G., Wang C., Jones M., Fellers G. M., Kunz T. H., Delwart E.. 2010b; Bat guano virome: predominance of dietary viruses from insects and plants plus novel mammalian viruses. J Virol84:6955–6965 [CrossRef][PubMed]
    [Google Scholar]
  14. Miller M. M., Jarosinski K. W., Schat K. A.. 2005; Positive and negative regulation of chicken anemia virus transcription. J Virol79:2859–2868 [CrossRef][PubMed]
    [Google Scholar]
  15. O’Ryan M., Díaz J., Mamani N., Navarrete M., Vallebuono C.. 2007; Impact of rotavirus infections on outpatient clinic visits in Chile. Pediatr Infect Dis J26:41–45 [CrossRef][PubMed]
    [Google Scholar]
  16. O’Ryan M. L., Lucero Y., Prado V., Santolaya M. E., Rabello M., Solis Y., Berríos D., O’Ryan-Soriano M. A., Cortés H., Mamani N.. 2009; Symptomatic and asymptomatic rotavirus and norovirus infections during infancy in a Chilean birth cohort. Pediatr Infect Dis J28:879–884 [CrossRef][PubMed]
    [Google Scholar]
  17. Peters M. A., Jackson D. C., Crabb B. S., Browning G. F.. 2002; Chicken anemia virus VP2 is a novel dual specificity protein phosphatase. J Biol Chem277:39566–39573 [CrossRef][PubMed]
    [Google Scholar]
  18. Phan T. G., Kapusinszky B., Wang C., Rose R. K., Lipton H. L., Delwart E. L.. 2011; The fecal viral flora of wild rodents. PLoS Pathog7:e1002218 [CrossRef][PubMed]
    [Google Scholar]
  19. Pietersen A., Noteborn H. M.. 2000; Apoptin. Adv Exp Med Biol465:153–161 [CrossRef][PubMed]
    [Google Scholar]
  20. Poon I. K., Oro C., Dias M. M., Zhang J., Jans D. A.. 2005a; Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells. Cancer Res65:7059–7064 [CrossRef][PubMed]
    [Google Scholar]
  21. Poon I. K., Oro C., Dias M. M., Zhang J. P., Jans D. A.. 2005b; A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin. J Virol79:1339–1341 [CrossRef][PubMed]
    [Google Scholar]
  22. Rijsewijk F. A., Dos Santos H. F., Teixeira T. F., Cibulski S. P., Varela A. P., Dezen D., Franco A. C., Roehe P. M.. 2011; Discovery of a genome of a distant relative of chicken anemia virus reveals a new member of the genus Gyrovirus . Arch Virol156:1097–1100 [CrossRef][PubMed]
    [Google Scholar]
  23. Rosenberger J. K., Cloud S. S.. 1989; The isolation and characterization of chicken anemia agent (CAA) from broilers in the United States. Avian Dis33:707–713 [CrossRef][PubMed]
    [Google Scholar]
  24. Saitou N., Nei M.. 1987; The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol4:406–425[PubMed]
    [Google Scholar]
  25. Sauvage V., Cheval J., Foulongne V., Gouilh M. A., Pariente K., Manuguerra J. C., Richardson J., Dereure O., Lecuit M.. other authors 2011; Identification of the first human gyrovirus, a virus related to chicken anemia virus. J Virol85:7948–7950 [CrossRef][PubMed]
    [Google Scholar]
  26. Schat K. A.. 2009; Chicken anemia virus. Curr Top Microbiol Immunol331:151–183 [CrossRef][PubMed]
    [Google Scholar]
  27. Takahashi K., Iwasa Y., Hijikata M., Mishiro S.. 2000; Identification of a new human DNA virus (TTV-like mini virus, TLMV) intermediately related to TT virus and chicken anemia virus. Arch Virol145:979–993 [CrossRef][PubMed]
    [Google Scholar]
  28. Toro H., McNulty M. S., Hidalgo H., Rosende S., Connor T. J.. 1994; Detection of chicken anemia virus antibodies in four poultry operations in Chile. Prev Vet Med21:103–106 [CrossRef]
    [Google Scholar]
  29. Toro H., Ewald S., Hoerr F. J.. 2006; Serological evidence of chicken infectious anemia virus in the United States at least since 1959. Avian Dis50:124–126 [CrossRef][PubMed]
    [Google Scholar]
  30. van Santen V. L., Joiner K. S., Murray C., Petrenko N., Hoerr F. J., Toro H.. 2004; Pathogenesis of chicken anemia virus: comparison of the oral and the intramuscular routes of infection. Avian Dis48:494–504 [CrossRef][PubMed]
    [Google Scholar]
  31. Victoria J. G., Kapoor A., Li L., Blinkova O., Slikas B., Wang C., Naeem A., Zaidi S., Delwart E.. 2009; Metagenomic analyses of viruses in stool samples from children with acute flaccid paralysis. J Virol83:4642–4651 [CrossRef][PubMed]
    [Google Scholar]
  32. Victoria J. G., Wang C., Jones M. S., Jaing C., McLoughlin K., Gardner S., Delwart E. L.. 2010; Viral nucleic acids in live-attenuated vaccines: detection of minority variants and an adventitious virus. J Virol84:6033–6040 [CrossRef][PubMed]
    [Google Scholar]
  33. Zhang T., Breitbart M., Lee W. H., Run J. Q., Wei C. L., Soh S. W., Hibberd M. L., Liu E. T., Rohwer F., Ruan Y.. 2006; RNA viral community in human feces: prevalence of plant pathogenic viruses. PLoS Biol4:e3 [CrossRef][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.041731-0
Loading
/content/journal/jgv/10.1099/vir.0.041731-0
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error