1887

Abstract

Until 2011 the genus in the family consisted of a single virus (Chicken anemia virus or CAV) causing a common immunosuppressive disease in chickens when a second gyrovirus (HGyV) was reported on the skin of 4 % of healthy humans. HGyV is very closely related to a recently described chicken gyrovirus, AGV2, suggesting that they belong to the same viral species. During a viral metagenomic analysis of 100 human faeces from children with diarrhoea in Chile we identified multiple known human pathogens (adenoviruses, enteroviruses, astroviruses, sapoviruses, noroviruses, parechoviruses and rotaviruses) and a novel gyrovirus species we named GyV3 sharing <63 % similarity with other gyrovirus proteins with evidence of recombination with CAV in its UTR. consensus PCR revealed a high prevalence of CAV DNA in diarrhoea and normal faeces from Chilean children and faeces of USA cats and dogs, which may reflect consumption of CAV-infected/vaccinated chickens. Whether GyV3 can infect humans and/or chickens requires further studies.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.041731-0
2012-06-01
2019-10-16
Loading full text...

Full text loading...

/deliver/fulltext/jgv/93/6/1356.html?itemId=/content/journal/jgv/10.1099/vir.0.041731-0&mimeType=html&fmt=ahah

References

  1. Adair B. M. . ( 2000; ). Immunopathogenesis of chicken anemia virus infection. . Dev Comp Immunol 24:, 247–255. [CrossRef] [PubMed]
    [Google Scholar]
  2. Bonkoungou I. J. , Sanou I. , Bon F. , Benon B. , Coulibaly S. O. , Haukka K. , Traoré A. S. , Barro N. . ( 2010; ). Epidemiology of rotavirus infection among young children with acute diarrhoea in Burkina Faso. . BMC Pediatr 10:, 94. [CrossRef] [PubMed]
    [Google Scholar]
  3. Craig M. I. , Rimondi A. , Delamer M. , Sansalone P. , König G. , Vagnozzi A. , Pereda A. . ( 2009; ). Molecular characterization of chicken infectious anemia virus circulating in Argentina during 2007. . Avian Dis 53:, 331–335. [CrossRef] [PubMed]
    [Google Scholar]
  4. Dos Santos H. F. , Knak M. B. , de Castro F. L. , Slongo J. , Ritterbusch G. A. , Klein T. A. , Esteves P. A. , Silva A. D. , Trevisol I. M. . & other authors ( 2012; ). Variants of the recently discovered avian gyrovirus 2 are detected in Southern Brazil and The Netherlands. . Vet Microbiol 155:, 230–236.[PubMed] [CrossRef]
    [Google Scholar]
  5. Ducatez M. F. , Owoade A. A. , Abiola J. O. , Muller C. P. . ( 2006; ). Molecular epidemiology of chicken anemia virus in Nigeria. . Arch Virol 151:, 97–111. [CrossRef] [PubMed]
    [Google Scholar]
  6. Eltahir Y. M. , Qian K. , Jin W. , Qin A. . ( 2011a; ). Analysis of chicken anemia virus genome: evidence of intersubtype recombination. . Virol J 8:, 512. [CrossRef] [PubMed]
    [Google Scholar]
  7. Eltahir Y. M. , Qian K. , Jin W. , Wang P. , Qin A. . ( 2011b; ). Molecular epidemiology of chicken anemia virus in commercial farms in China. . Virol J 8:, 145. [CrossRef] [PubMed]
    [Google Scholar]
  8. Hailemariam Z. , Omar A. R. , Hair-Bejo M. , Giap T. C. . ( 2008; ). Detection and characterization of chicken anemia virus from commercial broiler breeder chickens. . Virol J 5:, 128. [CrossRef] [PubMed]
    [Google Scholar]
  9. Ilyina T. V. , Koonin E. V. . ( 1992; ). Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria. . Nucleic Acids Res 20:, 3279–3285. [CrossRef] [PubMed]
    [Google Scholar]
  10. Kim H. R. , Kwon Y. K. , Bae Y. C. , Oem J. K. , Lee O. S. . ( 2010; ). Molecular characterization of chicken infectious anemia viruses detected from breeder and broiler chickens in South Korea. . Poult Sci 89:, 2426–2431. [CrossRef] [PubMed]
    [Google Scholar]
  11. Kimura M. . ( 1980; ). A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. . J Mol Evol 16:, 111–120. [CrossRef] [PubMed]
    [Google Scholar]
  12. Li L. , Kapoor A. , Slikas B. , Bamidele O. S. , Wang C. , Shaukat S. , Masroor M. A. , Wilson M. L. , Ndjango J. B. . & other authors ( 2010a; ). Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces. . J Virol 84:, 1674–1682. [CrossRef] [PubMed]
    [Google Scholar]
  13. Li L. , Victoria J. G. , Wang C. , Jones M. , Fellers G. M. , Kunz T. H. , Delwart E. . ( 2010b; ). Bat guano virome: predominance of dietary viruses from insects and plants plus novel mammalian viruses. . J Virol 84:, 6955–6965. [CrossRef] [PubMed]
    [Google Scholar]
  14. Miller M. M. , Jarosinski K. W. , Schat K. A. . ( 2005; ). Positive and negative regulation of chicken anemia virus transcription. . J Virol 79:, 2859–2868. [CrossRef] [PubMed]
    [Google Scholar]
  15. O’Ryan M. , Díaz J. , Mamani N. , Navarrete M. , Vallebuono C. . ( 2007; ). Impact of rotavirus infections on outpatient clinic visits in Chile. . Pediatr Infect Dis J 26:, 41–45. [CrossRef] [PubMed]
    [Google Scholar]
  16. O’Ryan M. L. , Lucero Y. , Prado V. , Santolaya M. E. , Rabello M. , Solis Y. , Berríos D. , O’Ryan-Soriano M. A. , Cortés H. , Mamani N. . ( 2009; ). Symptomatic and asymptomatic rotavirus and norovirus infections during infancy in a Chilean birth cohort. . Pediatr Infect Dis J 28:, 879–884. [CrossRef] [PubMed]
    [Google Scholar]
  17. Peters M. A. , Jackson D. C. , Crabb B. S. , Browning G. F. . ( 2002; ). Chicken anemia virus VP2 is a novel dual specificity protein phosphatase. . J Biol Chem 277:, 39566–39573. [CrossRef] [PubMed]
    [Google Scholar]
  18. Phan T. G. , Kapusinszky B. , Wang C. , Rose R. K. , Lipton H. L. , Delwart E. L. . ( 2011; ). The fecal viral flora of wild rodents. . PLoS Pathog 7:, e1002218. [CrossRef] [PubMed]
    [Google Scholar]
  19. Pietersen A. , Noteborn H. M. . ( 2000; ). Apoptin. . Adv Exp Med Biol 465:, 153–161. [CrossRef] [PubMed]
    [Google Scholar]
  20. Poon I. K. , Oro C. , Dias M. M. , Zhang J. , Jans D. A. . ( 2005a; ). Apoptin nuclear accumulation is modulated by a CRM1-recognized nuclear export signal that is active in normal but not in tumor cells. . Cancer Res 65:, 7059–7064. [CrossRef] [PubMed]
    [Google Scholar]
  21. Poon I. K. , Oro C. , Dias M. M. , Zhang J. P. , Jans D. A. . ( 2005b; ). A tumor cell-specific nuclear targeting signal within chicken anemia virus VP3/apoptin. . J Virol 79:, 1339–1341. [CrossRef] [PubMed]
    [Google Scholar]
  22. Rijsewijk F. A. , Dos Santos H. F. , Teixeira T. F. , Cibulski S. P. , Varela A. P. , Dezen D. , Franco A. C. , Roehe P. M. . ( 2011; ). Discovery of a genome of a distant relative of chicken anemia virus reveals a new member of the genus Gyrovirus . . Arch Virol 156:, 1097–1100. [CrossRef] [PubMed]
    [Google Scholar]
  23. Rosenberger J. K. , Cloud S. S. . ( 1989; ). The isolation and characterization of chicken anemia agent (CAA) from broilers in the United States. . Avian Dis 33:, 707–713. [CrossRef] [PubMed]
    [Google Scholar]
  24. Saitou N. , Nei M. . ( 1987; ). The neighbor-joining method: a new method for reconstructing phylogenetic trees. . Mol Biol Evol 4:, 406–425.[PubMed]
    [Google Scholar]
  25. Sauvage V. , Cheval J. , Foulongne V. , Gouilh M. A. , Pariente K. , Manuguerra J. C. , Richardson J. , Dereure O. , Lecuit M. . & other authors ( 2011; ). Identification of the first human gyrovirus, a virus related to chicken anemia virus. . J Virol 85:, 7948–7950. [CrossRef] [PubMed]
    [Google Scholar]
  26. Schat K. A. . ( 2009; ). Chicken anemia virus. . Curr Top Microbiol Immunol 331:, 151–183. [CrossRef] [PubMed]
    [Google Scholar]
  27. Takahashi K. , Iwasa Y. , Hijikata M. , Mishiro S. . ( 2000; ). Identification of a new human DNA virus (TTV-like mini virus, TLMV) intermediately related to TT virus and chicken anemia virus. . Arch Virol 145:, 979–993. [CrossRef] [PubMed]
    [Google Scholar]
  28. Toro H. , McNulty M. S. , Hidalgo H. , Rosende S. , Connor T. J. . ( 1994; ). Detection of chicken anemia virus antibodies in four poultry operations in Chile. . Prev Vet Med 21:, 103–106. [CrossRef]
    [Google Scholar]
  29. Toro H. , Ewald S. , Hoerr F. J. . ( 2006; ). Serological evidence of chicken infectious anemia virus in the United States at least since 1959. . Avian Dis 50:, 124–126. [CrossRef] [PubMed]
    [Google Scholar]
  30. van Santen V. L. , Joiner K. S. , Murray C. , Petrenko N. , Hoerr F. J. , Toro H. . ( 2004; ). Pathogenesis of chicken anemia virus: comparison of the oral and the intramuscular routes of infection. . Avian Dis 48:, 494–504. [CrossRef] [PubMed]
    [Google Scholar]
  31. Victoria J. G. , Kapoor A. , Li L. , Blinkova O. , Slikas B. , Wang C. , Naeem A. , Zaidi S. , Delwart E. . ( 2009; ). Metagenomic analyses of viruses in stool samples from children with acute flaccid paralysis. . J Virol 83:, 4642–4651. [CrossRef] [PubMed]
    [Google Scholar]
  32. Victoria J. G. , Wang C. , Jones M. S. , Jaing C. , McLoughlin K. , Gardner S. , Delwart E. L. . ( 2010; ). Viral nucleic acids in live-attenuated vaccines: detection of minority variants and an adventitious virus. . J Virol 84:, 6033–6040. [CrossRef] [PubMed]
    [Google Scholar]
  33. Zhang T. , Breitbart M. , Lee W. H. , Run J. Q. , Wei C. L. , Soh S. W. , Hibberd M. L. , Liu E. T. , Rohwer F. , Ruan Y. . ( 2006; ). RNA viral community in human feces: prevalence of plant pathogenic viruses. . PLoS Biol 4:, e3. [CrossRef] [PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.041731-0
Loading
/content/journal/jgv/10.1099/vir.0.041731-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error