1887

Abstract

A novel tick-borne bunyavirus (Huaiyangshan virus, HYSV), which causes haemorrhagic fever-like disease, has recently been reported in China. So far no animal experiments have been performed to study its pathogenesis. Towards developing an animal model for HYSV fever, newborn and adult mice and rats and golden hamsters were inoculated intracerebrally or intraperitoneally with HYSV. Newborn rats and newborn mice, especially Kunming (KM) mice, appeared highly susceptible. Remarkably, the KM mice that died of the HYSV infection developed large necrotic areas in the liver, while no obvious pathological changes were observed within the other organs. PCR and immunohistochemical analyses of the post-mortem material detected both HYSV antigen and RNA in almost all organs, indicating a systemic infection. Our data demonstrate that HYSV can cause a lethal infection of both newborn mice and newborn rats with apparent pathological damage of the liver. This animal model may help to understand the pathogenesis of the HYSV infection in humans.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.041053-0
2012-06-01
2020-01-29
Loading full text...

Full text loading...

/deliver/fulltext/jgv/93/6/1288.html?itemId=/content/journal/jgv/10.1099/vir.0.041053-0&mimeType=html&fmt=ahah

References

  1. Al-Hazmi M., Ayoola E. A., Abdurahman M., Banzal S., Ashraf J., El-Bushra A., Hazmi A., Abdullah M., Abbo H.. & other authors ( 2003;). Epidemic Rift Valley fever in Saudi Arabia: a clinical study of severe illness in humans. . Clin Infect Dis 36:, 245–252. [CrossRef][PubMed]
    [Google Scholar]
  2. Bente D. A., Alimonti J. B., Shieh W. J., Camus G., Ströher U., Zaki S., Jones S. M.. ( 2010;). Pathogenesis and immune response of Crimean–Congo hemorrhagic fever virus in a STAT-1 knockout mouse model. . J Virol 84:, 11089–11100. [CrossRef][PubMed]
    [Google Scholar]
  3. Burt F. J., Swanepoel R., Shieh W. J., Smith J. F., Leman P. A., Greer P. W., Coffield L. M., Rollin P. E., Ksiazek T. G.. & other authors ( 1997;). Immunohistochemical and in situ localization of Crimean–Congo hemorrhagic fever (CCHF) virus in human tissues and implications for CCHF pathogenesis. . Arch Pathol Lab Med 121:, 839–846.[PubMed]
    [Google Scholar]
  4. Ding X., Xu F., Chen H., Tesh R. B., Xiao S. Y.. ( 2005;). Apoptosis of hepatocytes caused by Punta Toro virus (Bunyaviridae: Phlebovirus) and its implication for Phlebovirus pathogenesis. . Am J Pathol 167:, 1043–1049. [CrossRef][PubMed]
    [Google Scholar]
  5. Ikegami T., Makino S.. ( 2011;). The pathogenesis of Rift Valley fever. . Viruses 3:, 493–519. [CrossRef][PubMed]
    [Google Scholar]
  6. Jonsson C. B., Figueiredo L. T., Vapalahti O.. ( 2010;). A global perspective on hantavirus ecology, epidemiology, and disease. . Clin Microbiol Rev 23:, 412–441. [CrossRef][PubMed]
    [Google Scholar]
  7. Klempa B., Fichet-Calvet E., Lecompte E., Auste B., Aniskin V., Meisel H., Denys C., Koivogui L., ter Meulen J., Krüger D. H.. ( 2006;). Hantavirus in African wood mouse, Guinea. . Emerg Infect Dis 12:, 838–840. [CrossRef][PubMed]
    [Google Scholar]
  8. Latham P. S., Sepelak S. B.. ( 1992;). Effect of macrophage source and activation on susceptibility in an age-dependent model of murine hepatitis caused by a phlebovirus, Punta Toro. . Arch Virol 122:, 175–185. [CrossRef][PubMed]
    [Google Scholar]
  9. Lee H. W., Lee P. W., Johnson K. M.. ( 1978;). Isolation of the etiologic agent of Korean hemorrhagic fever. . J Infect Dis 137:, 298–308. [CrossRef][PubMed]
    [Google Scholar]
  10. Nakamura T., Yanagihara R., Gibbs C. J. Jr, Amyx H. L., Gajdusek D. C.. ( 1985;). Differential susceptibility and resistance of immunocompetent and immunodeficient mice to fatal Hantaan virus infection. . Arch Virol 86:, 109–120. [CrossRef][PubMed]
    [Google Scholar]
  11. Nichol S. T.. ( 2001;). Bunyaviridae. . In Fields Virology, , 4th edn., pp. 1603–1633. Edited by Knipe D. M., Howley P... Philadelphia:: Lippincott Williams & Wilkins;.
    [Google Scholar]
  12. Plyusnin A., Elliott R.. (editors) ( 2011;). Bunyaviridae. . In Molecular and Cellular Biology. Caister Academic Press;.
    [Google Scholar]
  13. Plyusnin A., Beaty B. J., Elliott R. M., Goldbach R., Kormelink R., Lundkvist A., Schmaljohn C. S., Tesh R.B.. ( 2011;). Bunyaviridae. . In Virus Taxonomy: Classification and Nomenclature of Viruses: Ninth Report of the International Committee on Taxonomy of Viruses, pp. 693–709. Edited by King A. M. Q., Adams M. J., Carstens E. B., Lefkowitz E. J... San Diego:: Elsevier;.
    [Google Scholar]
  14. Sanchez A., Lukwiya M., Bausch D., Mahanty S., Sanchez A. J., Wagoner K. D., Rollin P. E.. ( 2004;). Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels. . J Virol 78:, 10370–10377. [CrossRef][PubMed]
    [Google Scholar]
  15. Schmaljohn C. S., Jennings G. B., Hay J., Dalrymple J. M.. ( 1986;). Coding strategy of the S genome segment of Hantaan virus. . Virology 155:, 633–643. [CrossRef][PubMed]
    [Google Scholar]
  16. Schmaljohn C. S., Nichol S. T.. ( 2001;). Hantaviruses. Curr Top Microbiol Immunol 256:, 1–196. [CrossRef][PubMed]
    [Google Scholar]
  17. Johnson K. M.. ( 2001;). Hantaviruses: history and overview. . Curr Top Microbiol Immunol 256:, 1–14. [CrossRef][PubMed]
    [Google Scholar]
  18. Smith D. R., Steele K. E., Shamblin J., Honko A., Johnson J., Reed C., Kennedy M., Chapman J. L., Hensley L. E.. ( 2010;). The pathogenesis of Rift Valley fever virus in the mouse model. . Virology 407:, 256–267. [CrossRef][PubMed]
    [Google Scholar]
  19. Srikiatkhachorn A., Gibbons R. V., Green S., Libraty D. H., Thomas S. J., Endy T. P., Vaughn D. W., Nisalak A., Ennis F. A.. & other authors ( 2010;). Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994–2005. . Clin Infect Dis 50:, 1135–1143. [CrossRef][PubMed]
    [Google Scholar]
  20. Swanepoel R., Manning B., Watt J. A.. ( 1979;). Fatal Rift Valley fever of man in Rhodesia. . Cent Afr J Med 25:, 1–8.[PubMed]
    [Google Scholar]
  21. Yu X. J., Liang M. F., Zhang S. Y., Liu Y., Li J. D., Sun Y. L., Zhang L., Zhang Q. F., Popov V. L.. & other authors ( 2011;). Fever with thrombocytopenia associated with a novel Bunyavirus in China. . N Engl J Med 364:, 1523–1532. [CrossRef][PubMed]
    [Google Scholar]
  22. Zhang L., Liu Y., Ni D., Li Q., Yu Y., Yu X. J., Wan K., Li D., Liang G.. & other authors ( 2008;). Nosocomial transmission of human granulocytic anaplasmosis in China. . JAMA 300:, 2263–2270. [CrossRef][PubMed]
    [Google Scholar]
  23. Zhang Y. Z., Zhou D. J., Xiong Y., Chen X. P., He Y. W., Sun Q., Yu B., Li J., Dai Y. A.. & other authors ( 2011;). [Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China]. . Zhonghua Liu Xing Bing Xue Za Zhi 32:, 209–220. (in Chinese).[PubMed]
    [Google Scholar]
  24. Zhang Y. Z., He Y. W., Dai Y. A., Xiong Y., Zheng H., Zhou D. J., Li J., Sun Q., Luo X. L.. & other authors ( 2012;). Hemorrhagic fever caused by a novel bunyavirus in China: pathogenesis and correlates of fatal outcome. . Clin Infect Dis 54:, 527–533. [CrossRef][PubMed]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.041053-0
Loading
/content/journal/jgv/10.1099/vir.0.041053-0
Loading

Data & Media loading...

Most cited articles

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error