1887

Abstract

Human polyomavirus 9 (HPyV9) was discovered recently in immunocompromised patients and shown to be genetically closely related to B-lymphotropic polyomavirus (LPyV). No serological data are available for HPyV9, but human antibodies against LPyV have been reported previously. To investigate the seroepidemiology of HPyV9 and the sero-cross-reactivity between HPyV9 and LPyV, a capsomer-based IgG ELISA was established using the major capsid protein VP1 of HPyV9 and LPyV. VP1 of an avian polyomavirus was used as control. For HPyV9, a seroprevalence of 47 % was determined in healthy adults and adolescents ( = 328) and 20 % in a group of children ( = 101). In both groups, the seroreactivities for LPyV were less frequent and the ELISA titres of LPyV were lower. Of the HPyV9-reactive sera, 47 % reacted also with LPyV, and the titres for both PyVs correlated. Sera from African green monkeys, the natural hosts of LPyV, reacted also with both HPyV9 and LPyV, but here the HPyV9 titres were lower. This potential sero-cross-reactivity between HPyV9 and LPyV was confirmed by competition assays, and it was hypothesized that the reactivity of human sera against LPyV may generally be due to cross-reactivity between HPyV9 and LPyV. The HPyV9 seroprevalence of liver transplant recipients and patients with neurological dysfunctions did not differ from that of age-matched controls, but a significantly higher seroprevalence was determined in renal and haematopoietic stem-cell transplant recipients, indicating that certain immunocompromised patient groups may be at a higher risk for primary infection with or for reactivation of HPyV9.

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2012-04-01
2019-12-07
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References

  1. Abend J. R. , Jiang M. , Imperiale M. J. . ( 2009; ). BK virus and human cancer: innocent until proven guilty. . Semin Cancer Biol 19:, 252–260. [CrossRef] [PubMed]
    [Google Scholar]
  2. Antonsson A. , Green A. C. , Mallitt K. A. , O’Rourke P. K. , Pawlita M. , Waterboer T. , Neale R. E. . ( 2010; ). Prevalence and stability of antibodies to the BK and JC polyomaviruses: a long-term longitudinal study of Australians. . J Gen Virol 91:, 1849–1853. [CrossRef] [PubMed]
    [Google Scholar]
  3. Barzon L. , Squarzon L. , Militello V. , Trevisan M. , Porzionato A. , Macchi V. , De Caro R. , Palù G. . ( 2009; ). WU and KI polyomaviruses in the brains of HIV-positive patients with and without progressive multifocal leukoencephalopathy. . J Infect Dis 200:, 1755–1758. [CrossRef] [PubMed]
    [Google Scholar]
  4. Becker J. C. , Schrama D. , Houben R. . ( 2009; ). Merkel cell carcinoma. . Cell Mol Life Sci 66:, 1–8. [CrossRef] [PubMed]
    [Google Scholar]
  5. Bodaghi S. , Comoli P. , Bösch R. , Azzi A. , Gosert R. , Leuenberger D. , Ginevri F. , Hirsch H. H. . ( 2009; ). Antibody responses to recombinant polyomavirus BK large T and VP1 proteins in young kidney transplant patients. . J Clin Microbiol 47:, 2577–2585. [CrossRef] [PubMed]
    [Google Scholar]
  6. Brade L. , Müller-Lantzsch N. , zur Hausen H. . ( 1980; ). B-lymphotropic papovavirus and possibility of infections in humans. . J Med Virol 6:, 301–308. [CrossRef] [PubMed]
    [Google Scholar]
  7. Carter J. J. , Paulson K. G. , Wipf G. C. , Miranda D. , Madeleine M. M. , Johnson L. G. , Lemos B. D. , Lee S. , Warcola A. H. . & other authors ( 2009; ). Association of Merkel cell polyomavirus-specific antibodies with Merkel cell carcinoma. . J Natl Cancer Inst 101:, 1510–1522. [CrossRef] [PubMed]
    [Google Scholar]
  8. Chen J. D. , Neilson K. , Van Dyke T. . ( 1989; ). Lymphotropic papovavirus early region is specifically regulated transgenic mice and efficiently induces neoplasia. . J Virol 63:, 2204–2214.[PubMed]
    [Google Scholar]
  9. Costa C. , Bergallo M. , Terlizzi M. E. , Cavallo G. P. , Cavalla P. , Cavallo R. . ( 2011; ). Lack of detection of lymphotropic polyomavirus DNA in different clinical specimens. . J Clin Virol 51:, 148–149. [CrossRef] [PubMed]
    [Google Scholar]
  10. Delbue S. , Tremolada S. , Branchetti E. , Elia F. , Gualco E. , Marchioni E. , Maserati R. , Ferrante P. . ( 2008; ). First identification and molecular characterization of lymphotropic polyomavirus in peripheral blood from patients with leukoencephalopathies. . J Clin Microbiol 46:, 2461–2462. [CrossRef] [PubMed]
    [Google Scholar]
  11. Delbue S. , Tremolada S. , Elia F. , Carloni C. , Amico S. , Tavazzi E. , Marchioni E. , Novati S. , Maserati R. , Ferrante P. . ( 2010; ). Lymphotropic polyomavirus is detected in peripheral blood from immunocompromised and healthy subjects. . J Clin Virol 47:, 156–160. [CrossRef] [PubMed]
    [Google Scholar]
  12. Eddy B. E. , Borman G. S. , Grubbs G. E. , Young R. D. . ( 1962; ). Identification of the oncogenic substance in rhesus monkey kidney cell culture as simian virus 40. . Virology 17:, 65–75. [CrossRef] [PubMed]
    [Google Scholar]
  13. Egli A. , Infanti L. , Dumoulin A. , Buser A. , Samaridis J. , Stebler C. , Gosert R. , Hirsch H. H. . ( 2009; ). Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors. . J Infect Dis 199:, 837–846. [CrossRef] [PubMed]
    [Google Scholar]
  14. Faust H. , Pastrana D. V. , Buck C. B. , Dillner J. , Ekström J. . ( 2011; ). Antibodies to Merkel cell polyomavirus correlate to presence of viral DNA in the skin. . J Infect Dis 203:, 1096–1100. [CrossRef] [PubMed]
    [Google Scholar]
  15. Feng H. , Shuda M. , Chang Y. , Moore P. S. . ( 2008; ). Clonal integration of a polyomavirus in human Merkel cell carcinoma. . Science 319:, 1096–1100. [CrossRef] [PubMed]
    [Google Scholar]
  16. Focosi D. , Maggi F. , Andreoli E. , Lanini L. , Ceccherini-Nelli L. , Petrini M. . ( 2009; ). Polyomaviruses other than JCV are not detected in progressive multifocal leukoencephalopathy. . J Clin Virol 45:, 161–162. [CrossRef] [PubMed]
    [Google Scholar]
  17. Gardner S. D. , Field A. M. , Coleman D. V. , Hulme B. . ( 1971; ). New human papovavirus (B.K.) isolated from urine after renal transplantation. . Lancet 297:, 1253–1257. [CrossRef] [PubMed]
    [Google Scholar]
  18. Gross L. . ( 1953; ). A filterable agent, recovered from Ak leukemic extracts, causing salivary gland carcinomas in C3H mice. . Proc Soc Exp Biol Med 83:, 414–421.[PubMed] [CrossRef]
    [Google Scholar]
  19. Hou J. , Major E. O. . ( 2000; ). Progressive multifocal leukoencephalopathy: JC virus induced demyelination in the immune compromised host. . J Neurovirol 6: (Suppl. 2), S98–S100.[PubMed]
    [Google Scholar]
  20. Jiang M. , Abend J. R. , Johnson S. F. , Imperiale M. J. . ( 2009; ). The role of polyomaviruses in human disease. . Virology 384:, 266–273. [CrossRef] [PubMed]
    [Google Scholar]
  21. Kean J. M. , Rao S. , Wang M. , Garcea R. L. . ( 2009; ). Seroepidemiology of human polyomaviruses. . PLoS Pathog 5:, e1000363. [CrossRef] [PubMed]
    [Google Scholar]
  22. Knowles W. A. , Pipkin P. , Andrews N. , Vyse A. , Minor P. , Brown D. W. , Miller E. . ( 2003; ). Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40. . J Med Virol 71:, 115–123. [CrossRef] [PubMed]
    [Google Scholar]
  23. Lopes da Silva R. . ( 2011; ). Polyoma BK virus: an emerging opportunistic infectious agent of the human central nervous system. . Braz J Infect Dis 15:, 276–284.[PubMed] [CrossRef]
    [Google Scholar]
  24. Maginnis M. S. , Atwood W. J. . ( 2009; ). JC virus: an oncogenic virus in animals and humans?. Semin Cancer Biol 19:, 261–269. [CrossRef] [PubMed]
    [Google Scholar]
  25. Matthews M. R. , Wang R. C. , Reddick R. L. , Saldivar V. A. , Browning J. C. . ( 2011; ). Viral-associated trichodysplasia spinulosa: a case with electron microscopic and molecular detection of the trichodysplasia spinulosa-associated human polyomavirus. . J Cutan Pathol 38:, 420–431. [CrossRef] [PubMed]
    [Google Scholar]
  26. Moens U. , Johannessen M. . ( 2008; ). Human polyomaviruses and cancer: expanding repertoire. . J Dtsch Dermatol Ges 6:, 704–708. [CrossRef] [PubMed]
    [Google Scholar]
  27. Neske F. , Prifert C. , Scheiner B. , Ewald M. , Schubert J. , Opitz A. , Weissbrich B. . ( 2010; ). High prevalence of antibodies against polyomavirus WU, polyomavirus KI, and human bocavirus in German blood donors. . BMC Infect Dis 10:, 215. [CrossRef] [PubMed]
    [Google Scholar]
  28. Nguyen N. L. , Le B.-M. , Wang D. . ( 2009; ). Serologic evidence of frequent human infection with WU and KI polyomaviruses. . Emerg Infect Dis 15:, 1199–1205. [CrossRef] [PubMed]
    [Google Scholar]
  29. Padgett B. L. , ZuRhein G. M. , Walker D. L. , Eckroade R. J. , Dessel B. H. . ( 1971; ). Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. . Lancet 297:, 1257–1260. [CrossRef] [PubMed]
    [Google Scholar]
  30. Pastrana D. V. , Tolstov Y. L. , Becker J. C. , Moore P. S. , Chang Y. , Buck C. B. . ( 2009; ). Quantitation of human seroresponsiveness to Merkel cell polyomavirus. . PLoS Pathog 5:, e1000578. [CrossRef] [PubMed]
    [Google Scholar]
  31. Sauvage V. , Foulongne V. , Cheval J. , Ar Gouilh M. , Pariente K. , Dereure O. , Manuguerra J. C. , Richardson J. , Lecuit M. . & other authors ( 2011; ). Human polyomavirus related to African green monkey lymphotropic polyomavirus. . Emerg Infect Dis 17:, 1364–1370.[PubMed]
    [Google Scholar]
  32. Schowalter R. M. , Pastrana D. V. , Pumphrey K. A. , Moyer A. L. , Buck C. B. . ( 2010; ). Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin. . Cell Host Microbe 7:, 509–515. [CrossRef] [PubMed]
    [Google Scholar]
  33. Scuda N. , Hofmann J. , Calvignac-Spencer S. , Ruprecht K. , Liman P. , Kühn J. , Hengel H. , Ehlers B. . ( 2011; ). A novel human polyomavirus closely related to the African green monkey-derived lymphotropic polyomavirus. . J Virol 85:, 4586–4590. [CrossRef] [PubMed]
    [Google Scholar]
  34. Stewart H. L. . ( 1953; ). Pulmonary tumors in animals with particular reference to mice. . Acta Unio Int Contra Cancrum 9:, 512–528.[PubMed]
    [Google Scholar]
  35. Takemoto K. K. , Segawa K. . ( 1983; ). A new monkey lymphotropic papovavirus: characterization of the virus and evidence of a related virus in humans. . Prog Clin Biol Res 105:, 87–96.[PubMed]
    [Google Scholar]
  36. Tolstov Y. L. , Pastrana D. V. , Feng H. , Becker J. C. , Jenkins F. J. , Moschos S. , Chang Y. , Buck C. B. , Moore P. S. . ( 2009; ). Human Merkel cell polyomavirus infection II. MCV is a common human infection that can be detected by conformational capsid epitope immunoassays. . Int J Cancer 125:, 1250–1256. [CrossRef] [PubMed]
    [Google Scholar]
  37. Touzé A. , Gaitan J. , Arnold F. , Cazal R. , Fleury M. J. , Combelas N. , Sizaret P. Y. , Guyetant S. , Maruani A. . & other authors ( 2010; ). Generation of Merkel cell polyomavirus (MCV)-like particles and their application to detection of MCV antibodies. . J Clin Microbiol 48:, 1767–1770. [CrossRef] [PubMed]
    [Google Scholar]
  38. van der Meijden E. , Janssens R. W. , Lauber C. , Bouwes Bavinck J. N. , Gorbalenya A. E. , Feltkamp M. C. . ( 2010; ). Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient. . PLoS Pathog 6:, e1001024. [CrossRef] [PubMed]
    [Google Scholar]
  39. van der Meijden E. , Kazem S. , Burgers M. M. , Janssens R. , Bouwes Bavinck J. N. , de Melker H. , Feltkamp M. C. . ( 2011; ). Seroprevalence of trichodysplasia spinulosa-associated polyomavirus. . Emerg Infect Dis 17:, 1355–1363.[PubMed]
    [Google Scholar]
  40. Viscidi R. P. , Clayman B. . ( 2006; ). Serological cross reactivity between polyomavirus capsids. . Adv Exp Med Biol 577:, 73–84. [CrossRef] [PubMed]
    [Google Scholar]
  41. Viscidi R. P. , Rollison D. E. , Sondak V. K. , Silver B. , Messina J. L. , Giuliano A. R. , Fulp W. , Ajidahun A. , Rivanera D. . ( 2011; ). Age-specific seroprevalence of Merkel cell polyomavirus, BK virus, and JC virus. . Clin Vaccine Immunol 18:, 1737–1743. [CrossRef] [PubMed]
    [Google Scholar]
  42. White M. K. , Gordon J. , Reiss K. , Del Valle L. , Croul S. , Giordano A. , Darbinyan A. , Khalili K. . ( 2005; ). Human polyomaviruses and brain tumors. . Brain Res Brain Res Rev 50:, 69–85. [CrossRef] [PubMed]
    [Google Scholar]
  43. zur Hausen H. . ( 2008; ). Novel human polyomaviruses – re-emergence of a well known virus family as possible human carcinogens. . Int J Cancer 123:, 247–250. [CrossRef] [PubMed]
    [Google Scholar]
  44. zur Hausen H. , Gissmann L. . ( 1979; ). Lymphotropic papovaviruses isolated from African green monkey and human cells. . Med Microbiol Immunol (Berl) 167:, 137–153. [CrossRef] [PubMed]
    [Google Scholar]
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