1887

Abstract

Hazara virus (HAZV) is closely related to the Crimean–Congo hemorrhagic fever virus (CCHFV). HAZV has not been reported to cause human disease; work with infectious material can be carried out at containment level (CL)-2. By contrast, CCHFV causes a haemorrhagic fever in humans and requires CL-4 facilities. A disease model of HAZV infection in mice deficient in the type I interferon receptor is reported in this study. Dose–response effects were seen with higher doses, resulting in a shorter time to death and earlier detection of viral loads in organs. The lowest dose of 10 p.f.u. was still lethal in over 50 % of the mice. Histopathological findings were identified in the liver, spleen and lymph nodes, with changes similar to a recent mouse model of CCHFV infection. The findings demonstrate that inoculation of mice with HAZV may act as a useful surrogate model for the testing of antiviral agents against CCHFV.

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2012-03-01
2020-01-23
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References

  1. Appannanavar S. B. , Mishra B. . ( 2011; ). An update on Crimean-Congo hemorrhagic fever. . J Glob Infect Dis 3:, 285–292. [CrossRef] [PubMed]
    [Google Scholar]
  2. Begum F. , Wissesman C. L. . ( 1970; ). Hazara (HAZ) strain. JC 280. . Am J Trop Med Hyg 19: (Suppl.), 1095–1096.[PubMed]
    [Google Scholar]
  3. Begum F. , Wisseman C. L. Jr , Casals J. . ( 1970; ). Tick-borne viruses of West Pakistan. II. Hazara virus, a new agent isolated from Ixodes redikorzevi ticks from the Kaghan Valley, W. Pakistan. . Am J Epidemiol 92:, 192–194.[PubMed]
    [Google Scholar]
  4. Bente D. A. , Alimonti J. B. , Shieh W. J. , Camus G. , Ströher U. , Zaki S. , Jones S. M. . ( 2010; ). Pathogenesis and immune response of Crimean-Congo hemorrhagic fever virus in a STAT-1 knockout mouse model. . J Virol 84:, 11089–11100. [CrossRef] [PubMed]
    [Google Scholar]
  5. Bereczky S. , Lindegren G. , Karlberg H. , Akerström S. , Klingström J. , Mirazimi A. . ( 2010; ). Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice. . J Gen Virol 91:, 1473–1477. [CrossRef] [PubMed]
    [Google Scholar]
  6. Berge T. O. , Chamberlain R. W. , Shope R. E. , Work T. H. . The Subcommittee on Information Exchange of The American Committee on Arthropod-Borne Viruses ( 1971; ). Catalogue of arthropod-borne and selected vertebrate viruses of the world. . Am J Trop Med Hyg 20: (Suppl.), 1018–1050.[PubMed]
    [Google Scholar]
  7. Bishop D. H. L. , Calisher C. H. , Casals J. , Chumakov M. P. , Gaidamovich S. Y. , Hannoun C. , Lvov D. K. , Marshall I. D. , Oker-Blom N. . & other authors ( 1980; ). Bunyaviridae . . Intervirology 14:, 125–143. [CrossRef] [PubMed]
    [Google Scholar]
  8. Casals J. , Tignor G. H. . ( 1974; ). Neutralization and hemagglutination-inhibition tests with Crimean hemorrhagic fever-Congo virus. . Proc Soc Exp Biol Med 145:, 960–966.[PubMed] [CrossRef]
    [Google Scholar]
  9. Casals J. , Tignor G. H. . ( 1980; ). The Nairovirus genus: serological relationships. . Intervirology 14:, 144–147. [CrossRef] [PubMed]
    [Google Scholar]
  10. Ergönül O. . ( 2006; ). Crimean-Congo haemorrhagic fever. . Lancet Infect Dis 6:, 203–214. [CrossRef] [PubMed]
    [Google Scholar]
  11. Flusin O. , Vigne S. , Peyrefitte C. N. , Bouloy M. , Crance J. M. , Iseni F. . ( 2011; ). Inhibition of Hazara nairovirus replication by small interfering RNAs and their combination with ribavirin. . Virol J 8:, 249. [CrossRef] [PubMed]
    [Google Scholar]
  12. Foulke R. S. , Rosato R. R. , French G. R. . ( 1981; ). Structural polypeptides of Hazara virus. . J Gen Virol 53:, 169–172. [CrossRef] [PubMed]
    [Google Scholar]
  13. Lan S. , McLay Schelde L. , Wang J. , Kumar N. , Ly H. , Liang Y. . ( 2009; ). Development of infectious clones for virulent and avirulent pichinde viruses: a model virus to study arenavirus-induced hemorrhagic fevers. . J Virol 83:, 6357–6362. [CrossRef] [PubMed]
    [Google Scholar]
  14. Leblebicioglu H. . ( 2010; ). Crimean-Congo haemorrhagic fever in Eurasia. . Int J Antimicrob Agents 36: (Suppl. 1), S43–S46. [CrossRef] [PubMed]
    [Google Scholar]
  15. Maltezou H. C. , Andonova L. , Andraghetti R. , Bouloy M. , Ergonul O. , Jongejan F. , Kalvatchev N. , Nichol S. , Niedrig M. . & other authors ( 2010; ). Crimean-Congo hemorrhagic fever in Europe: current situation calls for preparedness. . Euro Surveill 15:, 19504.[PubMed]
    [Google Scholar]
  16. Randhawa M. A. . ( 2009; ). Calculation of LD50 values from the method of Miller and Tainter, 1944. . J Ayub Med Coll Abbottabad 21:, 184–185.[PubMed]
    [Google Scholar]
  17. Smirnova S. E. , Shestopalova N. M. , Reingold V. N. , Zubri G. L. , Chumakov M. P. . ( 1977; ). Experimental Hazara virus infection in mice. . Acta Virol 21:, 128–132.[PubMed]
    [Google Scholar]
  18. Swanepoel R. , Gill D. E. , Shepherd A. J. , Leman P. A. , Mynhardt J. H. , Harvey S. . ( 1989; ). The clinical pathology of Crimean-Congo hemorrhagic fever. . Rev Infect Dis 11: (Suppl. 4), S794–S800. [CrossRef] [PubMed]
    [Google Scholar]
  19. Zapata J. C. , Pauza C. D. , Djavani M. M. , Rodas J. D. , Moshkoff D. , Bryant J. , Ateh E. , Garcia C. , Lukashevich I. S. , Salvato M. S. . ( 2011; ). Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. . Antiviral Res 92:, 125–138. [CrossRef] [PubMed]
    [Google Scholar]
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