1887

Abstract

Hazara virus (HAZV) is closely related to the Crimean–Congo hemorrhagic fever virus (CCHFV). HAZV has not been reported to cause human disease; work with infectious material can be carried out at containment level (CL)-2. By contrast, CCHFV causes a haemorrhagic fever in humans and requires CL-4 facilities. A disease model of HAZV infection in mice deficient in the type I interferon receptor is reported in this study. Dose–response effects were seen with higher doses, resulting in a shorter time to death and earlier detection of viral loads in organs. The lowest dose of 10 p.f.u. was still lethal in over 50 % of the mice. Histopathological findings were identified in the liver, spleen and lymph nodes, with changes similar to a recent mouse model of CCHFV infection. The findings demonstrate that inoculation of mice with HAZV may act as a useful surrogate model for the testing of antiviral agents against CCHFV.

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2012-03-01
2021-10-18
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References

  1. Appannanavar S. B., Mishra B. 2011; An update on Crimean-Congo hemorrhagic fever. J Glob Infect Dis 3:285–292 [View Article][PubMed]
    [Google Scholar]
  2. Begum F., Wissesman C. L. 1970; Hazara (HAZ) strain. JC 280. Am J Trop Med Hyg 19:Suppl.1095–1096[PubMed]
    [Google Scholar]
  3. Begum F., Wisseman C. L. Jr, Casals J. 1970; Tick-borne viruses of West Pakistan. II. Hazara virus, a new agent isolated from Ixodes redikorzevi ticks from the Kaghan Valley, W. Pakistan. Am J Epidemiol 92:192–194[PubMed]
    [Google Scholar]
  4. Bente D. A., Alimonti J. B., Shieh W. J., Camus G., Ströher U., Zaki S., Jones S. M. 2010; Pathogenesis and immune response of Crimean-Congo hemorrhagic fever virus in a STAT-1 knockout mouse model. J Virol 84:11089–11100 [View Article][PubMed]
    [Google Scholar]
  5. Bereczky S., Lindegren G., Karlberg H., Akerström S., Klingström J., Mirazimi A. 2010; Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice. J Gen Virol 91:1473–1477 [View Article][PubMed]
    [Google Scholar]
  6. Berge T. O., Chamberlain R. W., Shope R. E., Work T. H. The Subcommittee on Information Exchange of The American Committee on Arthropod-Borne Viruses 1971; Catalogue of arthropod-borne and selected vertebrate viruses of the world. Am J Trop Med Hyg 20:Suppl.1018–1050[PubMed]
    [Google Scholar]
  7. Bishop D. H. L., Calisher C. H., Casals J., Chumakov M. P., Gaidamovich S. Y., Hannoun C., Lvov D. K., Marshall I. D., Oker-Blom N. other authors 1980; Bunyaviridae . Intervirology 14:125–143 [View Article][PubMed]
    [Google Scholar]
  8. Casals J., Tignor G. H. 1974; Neutralization and hemagglutination-inhibition tests with Crimean hemorrhagic fever-Congo virus. Proc Soc Exp Biol Med 145:960–966[PubMed] [CrossRef]
    [Google Scholar]
  9. Casals J., Tignor G. H. 1980; The Nairovirus genus: serological relationships. Intervirology 14:144–147 [View Article][PubMed]
    [Google Scholar]
  10. Ergönül O. 2006; Crimean-Congo haemorrhagic fever. Lancet Infect Dis 6:203–214 [View Article][PubMed]
    [Google Scholar]
  11. Flusin O., Vigne S., Peyrefitte C. N., Bouloy M., Crance J. M., Iseni F. 2011; Inhibition of Hazara nairovirus replication by small interfering RNAs and their combination with ribavirin. Virol J 8:249 [View Article][PubMed]
    [Google Scholar]
  12. Foulke R. S., Rosato R. R., French G. R. 1981; Structural polypeptides of Hazara virus. J Gen Virol 53:169–172 [View Article][PubMed]
    [Google Scholar]
  13. Lan S., McLay Schelde L., Wang J., Kumar N., Ly H., Liang Y. 2009; Development of infectious clones for virulent and avirulent pichinde viruses: a model virus to study arenavirus-induced hemorrhagic fevers. J Virol 83:6357–6362 [View Article][PubMed]
    [Google Scholar]
  14. Leblebicioglu H. 2010; Crimean-Congo haemorrhagic fever in Eurasia. Int J Antimicrob Agents 36:Suppl. 1S43–S46 [View Article][PubMed]
    [Google Scholar]
  15. Maltezou H. C., Andonova L., Andraghetti R., Bouloy M., Ergonul O., Jongejan F., Kalvatchev N., Nichol S., Niedrig M. other authors 2010; Crimean-Congo hemorrhagic fever in Europe: current situation calls for preparedness. Euro Surveill 15:19504[PubMed]
    [Google Scholar]
  16. Randhawa M. A. 2009; Calculation of LD50 values from the method of Miller and Tainter, 1944. J Ayub Med Coll Abbottabad 21:184–185[PubMed]
    [Google Scholar]
  17. Smirnova S. E., Shestopalova N. M., Reingold V. N., Zubri G. L., Chumakov M. P. 1977; Experimental Hazara virus infection in mice. Acta Virol 21:128–132[PubMed]
    [Google Scholar]
  18. Swanepoel R., Gill D. E., Shepherd A. J., Leman P. A., Mynhardt J. H., Harvey S. 1989; The clinical pathology of Crimean-Congo hemorrhagic fever. Rev Infect Dis 11:Suppl. 4S794–S800 [View Article][PubMed]
    [Google Scholar]
  19. Zapata J. C., Pauza C. D., Djavani M. M., Rodas J. D., Moshkoff D., Bryant J., Ateh E., Garcia C., Lukashevich I. S., Salvato M. S. 2011; Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. Antiviral Res 92:125–138 [View Article][PubMed]
    [Google Scholar]
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